Combining oxytocin and cognitive bias modification training in a randomized controlled trial: Effects on trust in maternal support.

Verhees MWFT, van IJzendoorn MH, Bakermans-Kranenburg MJ, Ceulemans E, de Winter S, Santens T, Alaerts K, Casteels K, Salemink E, Verhaeghe J, Bosmans G

Journal of behavior therapy and experimental psychiatry24 Sept 2019Cited by 4 (Europe PMC)

PMID31610435DOI10.1016/j.jbtep.2019.101514PepBankPUB-31610435

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. 1 result from people.

01HumanRandomized controlled trialEfficacy outcome
In children aged 8-12 years, oxytocin had no main or interaction effects on trust-related interpretation bias or trust versus placebo.
In plain wordsIn children, oxytocin had no effect on trust-related thinking or trust, compared with placebo, alone or with training.
Peptide
Oxytocin
Outcome
No significant changeTrust-related interpretation bias and trust (oxytocin main and interaction effects)
Study
n = 100
Comparator
Placebo
Outcome group
Social behavior and cognition · Mental health and mood
Studied dose
Dose not stated
Source sentences
Summary
There were no main or interaction effects of oxytocin.
3 context sentences(design, population, supporting numbers)
Summary · context
Main and interaction effects were assessed on measures of trust-related interpretation bias and trust.
Summary · context
Children (N = 100, 8-12 years) were randomly assigned to one of two training conditions: CBM training aimed at increasing trust or neutral placebo training.
Summary · context
Within each training condition, half the participants received oxytocin and half a placebo.
Report a problemFND-3161043501

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

02HumanNot a test of Oxytocin aloneRandomized controlled trialEfficacy outcome
In an exploratory analysis in children, oxytocin combined with CBM training had less positive effects on trust for children with more internalizing problems.
In plain wordsIn an exploratory test, oxytocin plus trust training worked less well for children with more internalizing problems.
Peptide
Oxytocin
Outcome
DecreaseTrust in maternal support, oxytocin combined with CBM training, by internalizing problems
Study
n: not reported in source
Analysis
Exploratory
Outcome group
Social behavior and cognition · Mental health and mood
Source sentences
Summary
Exploratory moderation analyses indicated that combining CBM training with oxytocin had less positive effects on trust for children with more internalizing problems.
2 context sentences(design, population, supporting numbers)
Summary · context
Children (N = 100, 8-12 years) were randomly assigned to one of two training conditions: CBM training aimed at increasing trust or neutral placebo training.
Summary · context
Within each training condition, half the participants received oxytocin and half a placebo.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-3161043502

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 00:50 UTC
Study results updated
Version 1
9 Oct 2026, 02:48 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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