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Study · Randomized controlled trial · n = 47 · 2019

2 results

Effects of Oxytocin Administration on Cue-Induced Craving in Co-occurring Alcohol Use Disorder and PTSD: A Within-Participant Randomized Clinical Trial.

Stauffer CS, Meinzer NK, Morrison T, Wen JH, Radanovich L, Leung D, Niles A, O'Donovan A, Batki SL, Woolley JD

Alcoholism, clinical and experimental research6 Nov 2019Cited by 16 (Europe PMC)

PMID31610033 (opens in a new tab)PMCIDPMC7450809 (opens in a new tab)DOI10.1111/acer.14217 (opens in a new tab)PepBankPUB-31610033
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In male patients with comorbid alcohol use disorder and PTSD, neither 20 IU nor 40 IU intranasal oxytocin reduced self-reported cue-induced alcohol craving versus placebo.

    In plain wordsIn men with alcohol use disorder and PTSD, oxytocin did not reduce alcohol craving triggered by cues, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeCue-induced alcohol craving (self-reported)
    Study

    n = 47

    Comparator
    Placebo
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    20 IU and 40 IU · intranasal · single dose per visitAs given in this study (human).

    Source sentences

    Summary
    While alcohol cues significantly induced self-reported craving and increased HR compared to neutral water cues, neither dosage of oxytocin compared to placebo reduced self-reported cue-induced alcohol craving nor cue-induced changes in HR in patients with PTSD-AUD.
    2 context sentences
    Summary · context
    Forty-seven male patients with comorbid AUD-PTSD were administered intranasal oxytocin in a randomized, double-blind, dose-ranging (20 IU, 40 IU, and matched placebo), within-participant design with study visits at least 1 week apart.
    Summary · context
    A cue-induced craving paradigm was conducted using each participant's preferred alcoholic beverage versus a neutral water cue.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In male patients with comorbid alcohol use disorder and PTSD, neither oxytocin dose changed the cue-induced heart rate response versus placebo.

    In plain wordsIn men with alcohol use disorder and PTSD, oxytocin did not change the heart rate response to alcohol cues, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeCue-induced heart rate change
    Study

    n = 47

    Comparator
    Placebo
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    20 IU and 40 IU · intranasal · single dose per visitAs given in this study (human).

    Source sentences

    Summary
    While alcohol cues significantly induced self-reported craving and increased HR compared to neutral water cues, neither dosage of oxytocin compared to placebo reduced self-reported cue-induced alcohol craving nor cue-induced changes in HR in patients with PTSD-AUD.
    2 context sentences
    Summary · context
    A cue-induced craving paradigm was conducted using each participant's preferred alcoholic beverage versus a neutral water cue.
    Summary · context
    Forty-seven male patients with comorbid AUD-PTSD were administered intranasal oxytocin in a randomized, double-blind, dose-ranging (20 IU, 40 IU, and matched placebo), within-participant design with study visits at least 1 week apart.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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