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Study · Not a test of the peptide alone · 2020

2 results

Human RECQL4 represses the RAD52-mediated single-strand annealing pathway after ionizing radiation or cisplatin treatment.

Kohzaki M, Ootsuyama A, Sun L, Moritake T, Okazaki R

International journal of cancer6 Oct 2019Cited by 17 (Europe PMC)

PMID31495919 (opens in a new tab)DOI10.1002/ijc.32670 (opens in a new tab)PepBankPUB-31495919
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01AnimalNot a test of AICAR (acadesine) aloneAnimal study (in vivo)Efficacy outcome

    In mouse xenografts, RAD52-targeting interventions including AICAR significantly restrained RECQL4ΔC HCT116 growth.

    In plain wordsIn mice, pooled RAD52-targeting interventions including AICAR reduced transplanted tumor cell growth.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCell growth
    Study

    mousen: not reported in source

    RECQL4ΔC HCT116 xenografts
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    RAD52 depletion by siRNA or RAD52 inhibitors (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside [AICAR], (-)-epigallocatechin [EGC]) or a RAD52-phenylalanine 79 aptamer significantly restrained the growth of RAD52-upregulated RECQL4ΔC HCT116 cells in vitro and in mouse xenografts.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 02LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Efficacy outcome

    In RECQL4ΔC HCT116 cells, RAD52 depletion or inhibitors including AICAR or an aptamer restrained growth in vitro.

    In plain wordsIn cells, pooled RAD52-targeting interventions including AICAR reduced growth.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCell growth
    Study

    humann: not reported in source

    RAD52-upregulated RECQL4ΔC HCT116 cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    RAD52 depletion by siRNA or RAD52 inhibitors (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside [AICAR], (-)-epigallocatechin [EGC]) or a RAD52-phenylalanine 79 aptamer significantly restrained the growth of RAD52-upregulated RECQL4ΔC HCT116 cells in vitro and in mouse xenografts.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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