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Study · Randomized controlled trial · n = 80 · 2020

3 results

Effects of Oxytocin on Placebo and Nocebo Effects in a Pain Conditioning Paradigm: A Randomized Controlled Trial.

Skvortsova A, Veldhuijzen DS, van Middendorp H, Colloca L, Evers AWM

The journal of pain5 Sept 2019Cited by 21 (Europe PMC)

PMID31494273 (opens in a new tab)PMCIDPMC7408480 (opens in a new tab)DOI10.1016/j.jpain.2019.08.010 (opens in a new tab)PepBankPUB-31494273
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In male volunteers, oxytocin did not influence placebo analgesia versus placebo control.

    In plain wordsIn men, oxytocin nasal spray did not change placebo pain relief, compared with a placebo spray.

    Peptide
    Oxytocin
    Outcome
    No significant changePlacebo analgesia
    Study

    n = 80

    Comparator
    Placebo
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin did not influence placebo analgesia or nocebo hyperalgesia and had no effect on extinction.
    1 context sentence
    Summary · context
    Eighty male volunteers were assigned to a 40 IU of oxytocin nasal spray group, or to a placebo control group.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In male volunteers, oxytocin did not influence nocebo hyperalgesia versus placebo control.

    In plain wordsIn men, oxytocin nasal spray did not change nocebo-increased pain, compared with a placebo spray.

    Peptide
    Oxytocin
    Outcome
    No significant changeNocebo hyperalgesia
    Study

    n = 80

    Comparator
    Placebo
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin did not influence placebo analgesia or nocebo hyperalgesia and had no effect on extinction.
    1 context sentence
    Summary · context
    Eighty male volunteers were assigned to a 40 IU of oxytocin nasal spray group, or to a placebo control group.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In male volunteers, oxytocin had no effect on extinction of placebo and nocebo responses versus placebo control.

    In plain wordsIn men, oxytocin nasal spray did not change how placebo and nocebo responses faded, compared with a placebo spray.

    Peptide
    Oxytocin
    Outcome
    No significant changeExtinction of placebo and nocebo responses
    Study

    n = 80

    Comparator
    Placebo
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin did not influence placebo analgesia or nocebo hyperalgesia and had no effect on extinction.
    1 context sentence
    Summary · context
    Eighty male volunteers were assigned to a 40 IU of oxytocin nasal spray group, or to a placebo control group.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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