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Study · Animal study (in vivo) · rat · 2020

12 results

Randomized controlled trial of Cerebrolysin's effects on long-term histological outcomes and functional recovery in rats with moderate closed head injury.

Zhang Y, Chopp M, Zhang Y, Gang Zhang Z, Lu M, Zhang T, Wu KH, Zhang L, Mahmood A, Xiong Y

Journal of neurosurgery6 Sept 2019Cited by 5 (Europe PMC)

PMID31491768 (opens in a new tab)DOI10.3171/2019.6.jns191027 (opens in a new tab)PepBankPUB-31491768
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with moderate closed head injury, Cerebrolysin increased dentate gyrus neuroblasts versus saline.

    In plain wordsIn rats with head injury, Cerebrolysin increased immature nerve cells in the dentate gyrus versus saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseDentate gyrus neuroblasts
    Study

    ratsn = 26

    Male adult Wistar rats with moderate closed head injury
    Comparator
    Saline vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg daily · intraperitoneal · 10 daysAs given in this study (rats).

    Source sentences

    Summary
    Compared with rats treated with vehicle (saline), rats treated with Cerebrolysin had significantly increased numbers of neuroblasts and newborn mature neurons in the dentate gyrus (DG)
    2 context sentences
    Summary · context
    In this randomized, blinded, and vehicle-controlled preclinical trial, male adult Wistar rats subjected to moderate CHI received either Cerebrolysin treatment at a dose of 2.5 ml/kg (n = 13) or vehicle (saline, n = 13) intraperitoneally administered daily for 10 days, starting at 4 hours after injury.
    Summary · context
    Animals were subjected to cognitive and sensorimotor functional tests at multiple time points, and they were killed 3 months after injury.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with moderate closed head injury, Cerebrolysin increased newborn mature neurons in the dentate gyrus versus saline.

    In plain wordsIn rats with head injury, Cerebrolysin increased new mature nerve cells in the dentate gyrus versus saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseDentate gyrus newborn mature neurons
    Study

    ratsn = 26

    Male adult Wistar rats with moderate closed head injury
    Comparator
    Saline vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg daily · intraperitoneal · 10 daysAs given in this study (rats).

    Source sentences

    Summary
    Compared with rats treated with vehicle (saline), rats treated with Cerebrolysin had significantly increased numbers of neuroblasts and newborn mature neurons in the dentate gyrus (DG)
    2 context sentences
    Summary · context
    In this randomized, blinded, and vehicle-controlled preclinical trial, male adult Wistar rats subjected to moderate CHI received either Cerebrolysin treatment at a dose of 2.5 ml/kg (n = 13) or vehicle (saline, n = 13) intraperitoneally administered daily for 10 days, starting at 4 hours after injury.
    Summary · context
    Animals were subjected to cognitive and sensorimotor functional tests at multiple time points, and they were killed 3 months after injury.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with moderate closed head injury, Cerebrolysin reduced amyloid precursor protein accumulation in brain regions versus saline.

    In plain wordsIn rats with head injury, Cerebrolysin reduced amyloid precursor protein accumulation in brain regions versus saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseAmyloid precursor protein accumulation
    Study

    ratsn = 26

    Male adult Wistar rats with moderate closed head injury
    Comparator
    Saline vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg daily · intraperitoneal · 10 daysAs given in this study (rats).

    Source sentences

    Summary
    and attenuated amyloid precursor protein accumulation and axonal damage in various brain regions
    2 context sentences
    Summary · context
    In this randomized, blinded, and vehicle-controlled preclinical trial, male adult Wistar rats subjected to moderate CHI received either Cerebrolysin treatment at a dose of 2.5 ml/kg (n = 13) or vehicle (saline, n = 13) intraperitoneally administered daily for 10 days, starting at 4 hours after injury.
    Summary · context
    Animals were subjected to cognitive and sensorimotor functional tests at multiple time points, and they were killed 3 months after injury.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with moderate closed head injury, Cerebrolysin reduced axonal damage in brain regions versus saline.

    In plain wordsIn rats with head injury, Cerebrolysin reduced damage to nerve fibers versus saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseAxonal damage
    Study

    ratsn = 26

    Male adult Wistar rats with moderate closed head injury
    Comparator
    Saline vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg daily · intraperitoneal · 10 daysAs given in this study (rats).

    Source sentences

    Summary
    and attenuated amyloid precursor protein accumulation and axonal damage in various brain regions
    2 context sentences
    Summary · context
    In this randomized, blinded, and vehicle-controlled preclinical trial, male adult Wistar rats subjected to moderate CHI received either Cerebrolysin treatment at a dose of 2.5 ml/kg (n = 13) or vehicle (saline, n = 13) intraperitoneally administered daily for 10 days, starting at 4 hours after injury.
    Summary · context
    Animals were subjected to cognitive and sensorimotor functional tests at multiple time points, and they were killed 3 months after injury.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with moderate closed head injury, Cerebrolysin reduced neuronal loss in the dentate gyrus versus saline.

    In plain wordsIn rats with head injury, Cerebrolysin reduced nerve cell loss in the dentate gyrus versus saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseDentate gyrus neuronal loss
    Study

    ratsn = 26

    Male adult Wistar rats with moderate closed head injury
    Comparator
    Saline vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg daily · intraperitoneal · 10 daysAs given in this study (rats).

    Source sentences

    Summary
    as well as decreased neuronal loss in the DG and cornu ammonis 3 (CA3) region of the hippocampus (p < 0.05).
    2 context sentences
    Summary · context
    In this randomized, blinded, and vehicle-controlled preclinical trial, male adult Wistar rats subjected to moderate CHI received either Cerebrolysin treatment at a dose of 2.5 ml/kg (n = 13) or vehicle (saline, n = 13) intraperitoneally administered daily for 10 days, starting at 4 hours after injury.
    Summary · context
    Animals were subjected to cognitive and sensorimotor functional tests at multiple time points, and they were killed 3 months after injury.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with moderate closed head injury, Cerebrolysin reduced neuronal loss in hippocampal CA3 versus saline.

    In plain wordsIn rats with head injury, Cerebrolysin reduced nerve cell loss in hippocampal CA3 versus saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseCA3 neuronal loss
    Study

    ratsn = 26

    Male adult Wistar rats with moderate closed head injury
    Comparator
    Saline vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg daily · intraperitoneal · 10 daysAs given in this study (rats).

    Source sentences

    Summary
    as well as decreased neuronal loss in the DG and cornu ammonis 3 (CA3) region of the hippocampus (p < 0.05).
    2 context sentences
    Summary · context
    In this randomized, blinded, and vehicle-controlled preclinical trial, male adult Wistar rats subjected to moderate CHI received either Cerebrolysin treatment at a dose of 2.5 ml/kg (n = 13) or vehicle (saline, n = 13) intraperitoneally administered daily for 10 days, starting at 4 hours after injury.
    Summary · context
    Animals were subjected to cognitive and sensorimotor functional tests at multiple time points, and they were killed 3 months after injury.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with moderate closed head injury, Cerebrolysin improved sensorimotor outcomes from 1 day to 3 months versus saline.

    In plain wordsIn rats with head injury, Cerebrolysin improved sensorimotor outcomes from 1 day to 3 months versus saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSensorimotor functional recovery
    Study

    ratsn = 26

    Male adult Wistar rats with moderate closed head injury
    Comparator
    Saline vehicle
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    2.5 ml/kg daily · intraperitoneal · 10 daysAs given in this study (rats).

    Source sentences

    Summary
    Global testing using generalized estimating equations showed a significant beneficial effect of Cerebrolysin treatment on sensorimotor functional outcomes from 1 day to 3 months after injury compared to that of saline treatment (p < 0.05).
    2 context sentences
    Summary · context
    In this randomized, blinded, and vehicle-controlled preclinical trial, male adult Wistar rats subjected to moderate CHI received either Cerebrolysin treatment at a dose of 2.5 ml/kg (n = 13) or vehicle (saline, n = 13) intraperitoneally administered daily for 10 days, starting at 4 hours after injury.
    Summary · context
    Animals were subjected to cognitive and sensorimotor functional tests at multiple time points, and they were killed 3 months after injury.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with moderate closed head injury, Cerebrolysin improved long-term cognitive recovery measured by social interaction versus vehicle.

    In plain wordsIn rats with head injury, Cerebrolysin improved long-term cognitive recovery measured by social interaction versus vehicle.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSocial interaction test recovery
    Study

    ratsn = 26

    Male adult Wistar rats with moderate closed head injury
    Comparator
    Saline vehicle
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 ml/kg daily · intraperitoneal · 10 daysAs given in this study (rats).

    Source sentences

    Summary
    Compared with vehicle-treated rats, Cerebrolysin-treated rats showed significantly and robustly improved long-term (up to 3 months) cognitive functional recovery, as measured by social interaction, Morris water maze, novel object recognition, and odor recognition tests.
    2 context sentences
    Summary · context
    In this randomized, blinded, and vehicle-controlled preclinical trial, male adult Wistar rats subjected to moderate CHI received either Cerebrolysin treatment at a dose of 2.5 ml/kg (n = 13) or vehicle (saline, n = 13) intraperitoneally administered daily for 10 days, starting at 4 hours after injury.
    Summary · context
    Animals were subjected to cognitive and sensorimotor functional tests at multiple time points, and they were killed 3 months after injury.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats with moderate closed head injury, Cerebrolysin improved long-term cognitive recovery measured by the Morris water maze versus vehicle.

    In plain wordsIn rats with head injury, Cerebrolysin improved long-term cognitive recovery measured by the Morris water maze versus vehicle.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMorris water maze recovery
    Study

    ratsn = 26

    Male adult Wistar rats with moderate closed head injury
    Comparator
    Saline vehicle
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 ml/kg daily · intraperitoneal · 10 daysAs given in this study (rats).

    Source sentences

    Summary
    Compared with vehicle-treated rats, Cerebrolysin-treated rats showed significantly and robustly improved long-term (up to 3 months) cognitive functional recovery, as measured by social interaction, Morris water maze, novel object recognition, and odor recognition tests.
    2 context sentences
    Summary · context
    In this randomized, blinded, and vehicle-controlled preclinical trial, male adult Wistar rats subjected to moderate CHI received either Cerebrolysin treatment at a dose of 2.5 ml/kg (n = 13) or vehicle (saline, n = 13) intraperitoneally administered daily for 10 days, starting at 4 hours after injury.
    Summary · context
    Animals were subjected to cognitive and sensorimotor functional tests at multiple time points, and they were killed 3 months after injury.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats with moderate closed head injury, Cerebrolysin improved long-term cognitive recovery measured by novel object recognition versus vehicle.

    In plain wordsIn rats with head injury, Cerebrolysin improved long-term cognitive recovery measured by novel object recognition versus vehicle.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNovel object recognition recovery
    Study

    ratsn = 26

    Male adult Wistar rats with moderate closed head injury
    Comparator
    Saline vehicle
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 ml/kg daily · intraperitoneal · 10 daysAs given in this study (rats).

    Source sentences

    Summary
    Compared with vehicle-treated rats, Cerebrolysin-treated rats showed significantly and robustly improved long-term (up to 3 months) cognitive functional recovery, as measured by social interaction, Morris water maze, novel object recognition, and odor recognition tests.
    2 context sentences
    Summary · context
    In this randomized, blinded, and vehicle-controlled preclinical trial, male adult Wistar rats subjected to moderate CHI received either Cerebrolysin treatment at a dose of 2.5 ml/kg (n = 13) or vehicle (saline, n = 13) intraperitoneally administered daily for 10 days, starting at 4 hours after injury.
    Summary · context
    Animals were subjected to cognitive and sensorimotor functional tests at multiple time points, and they were killed 3 months after injury.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In rats with moderate closed head injury, Cerebrolysin improved long-term cognitive recovery measured by odor recognition versus vehicle.

    In plain wordsIn rats with head injury, Cerebrolysin improved long-term cognitive recovery measured by odor recognition versus vehicle.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseOdor recognition recovery
    Study

    ratsn = 26

    Male adult Wistar rats with moderate closed head injury
    Comparator
    Saline vehicle
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    2.5 ml/kg daily · intraperitoneal · 10 daysAs given in this study (rats).

    Source sentences

    Summary
    Compared with vehicle-treated rats, Cerebrolysin-treated rats showed significantly and robustly improved long-term (up to 3 months) cognitive functional recovery, as measured by social interaction, Morris water maze, novel object recognition, and odor recognition tests.
    2 context sentences
    Summary · context
    In this randomized, blinded, and vehicle-controlled preclinical trial, male adult Wistar rats subjected to moderate CHI received either Cerebrolysin treatment at a dose of 2.5 ml/kg (n = 13) or vehicle (saline, n = 13) intraperitoneally administered daily for 10 days, starting at 4 hours after injury.
    Summary · context
    Animals were subjected to cognitive and sensorimotor functional tests at multiple time points, and they were killed 3 months after injury.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In Cerebrolysin-treated rats with moderate closed head injury, histological outcomes correlated significantly with functional recovery at 3 months.

    In plain wordsIn Cerebrolysin-treated rats with head injury, tissue outcomes were linked to functional recovery at 3 months.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableHistological-functional correlations
    Study

    ratsn = 13

    Male adult Wistar rats with moderate closed head injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2.5 ml/kg daily · intraperitoneal · 10 daysAs given in this study (rats).

    Source sentences

    Summary
    In the Cerebrolysin-treated rats there were significant correlations between multiple histological outcomes and functional recovery evident 3 months after moderate CHI, as indicated by Pearson partial correlation analyses.
    2 context sentences
    Summary · context
    In this randomized, blinded, and vehicle-controlled preclinical trial, male adult Wistar rats subjected to moderate CHI received either Cerebrolysin treatment at a dose of 2.5 ml/kg (n = 13) or vehicle (saline, n = 13) intraperitoneally administered daily for 10 days, starting at 4 hours after injury.
    Summary · context
    Animals were subjected to cognitive and sensorimotor functional tests at multiple time points, and they were killed 3 months after injury.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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