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Study · Animal study (in vivo) · bos taurus heifers · 2020

3 results

Intranasal oxytocin treatment does not attenuate the hypothalamo-pituitary-adrenal axis in beef heifers subjected to isolation stress or restraint and isolation stress.

Wagner BK, Relling AE, Kieffer JD, Parker AJ

Domestic animal endocrinology24 Jul 2019Cited by 7 (Europe PMC)

PMID31479924 (opens in a new tab)DOI10.1016/j.domaniend.2019.07.007 (opens in a new tab)PepBankPUB-31479924
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In beef heifers under isolation or restraint stress, intranasal oxytocin did not affect measured indicators of HPA axis activation versus saline.

    In plain wordsIn heifers under stress, oxytocin sprayed in the nose did not change stress hormone measures, compared with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeHPA axis activation (cortisol and ACTH)
    Study

    Bos taurus heifersn = 28

    isolation stress, or restraint and isolation stress
    Comparator
    Saline
    Outcome group
    Anxiety and mood · Endocrine and hormones
    Studied dose
    0.3 IU/kg BW · intranasalAs given in this study (Bos taurus heifers).

    Source sentences

    Summary
    Under the conditions of the present study, OXT treatment did not affect measured indicators of HPA axis activation.
    2 context sentences
    Summary · context
    Twenty-eight Bos taurus heifers were blocked by bodyweight and randomly allocated to one of four treatment groups
    Summary · context
    Oxytocin and saline were administered intranasally.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In beef heifers, intranasal oxytocin gave greater initial plasma oxytocin concentrations followed by a decline, while saline-treated heifers had stable concentrations.

    In plain wordsIn heifers, oxytocin sprayed in the nose raised blood oxytocin at first and then it fell; saline heifers stayed stable.

    Peptide
    Oxytocin
    Outcome
    MixedPlasma oxytocin concentration over time
    Study

    Bos taurus heifersn = 28

    isolation stress, or restraint and isolation stress
    Comparator
    Saline
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    0.3 IU/kg BW · intranasalAs given in this study (Bos taurus heifers).

    Source sentences

    Summary
    A treatment × time interaction (P < 0.01) was detected for OXT, such that OXT heifers exhibited greater initial OXT concentrations followed by a decline; saline-treated heifers had consistently stable oxytocin concentrations.
    2 context sentences
    Summary · context
    Twenty-eight Bos taurus heifers were blocked by bodyweight and randomly allocated to one of four treatment groups
    Summary · context
    Oxytocin and saline were administered intranasally.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In beef heifers, restraint and isolation stress increased the body's own oxytocin concentrations compared with isolation alone.

    In plain wordsIn heifers, restraint raised the body's own oxytocin level more than isolation alone did.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin concentration after restraint stress
    Study

    Bos taurus heifersn = 28

    isolation stress, or restraint and isolation stress
    Comparator
    Isolation only
    Outcome group
    Anxiety and mood · Endocrine and hormones

    Source sentences

    Summary
    Overall, restraint stress increased cortisol and oxytocin in B taurus heifers compared with heifers subjected only to isolation.
    1 context sentence
    Summary · context
    Twenty-eight Bos taurus heifers were blocked by bodyweight and randomly allocated to one of four treatment groups

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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