Skip to content

Study · Randomized controlled trial · n = 13 · 2019

5 results

Oxytocin modulates alcohol-cue induced functional connectivity in the nucleus accumbens of social drinkers.

Bach P, Reinhard I, Bühler S, Vollstädt-Klein S, Kiefer F, Koopmann A

Psychoneuroendocrinology24 Jul 2019Cited by 29 (Europe PMC)

PMID31362183 (opens in a new tab)DOI10.1016/j.psyneuen.2019.104385 (opens in a new tab)PepBankPUB-31362183
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In male social drinkers, intranasal oxytocin reduced nucleus accumbens connectivity with the cuneus during an alcohol cue-reactivity task.

    In plain wordsIn male social drinkers, nasal oxytocin reduced brain connectivity between the nucleus accumbens and the cuneus while they viewed alcohol cues.

    Peptide
    Oxytocin
    Outcome
    DecreaseNucleus accumbens connectivity with the cuneus during alcohol cues
    Study

    n = 13

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin application significantly reduced NAc connectivity with the cuneus and thalamo-occipital connectivity, while enhancing connectivity between the paracingulate gyrus and precentral gyrus.
    1 context sentence
    Summary · context
    Thirteen male social drinkers participated in a randomized double-blind placebo-controlled cross-over functional magnetic resonance imaging (fMRI) alcohol cue-reactivity task with and without prior intranasal application of 24 IU oxytocin.
  2. 02HumanRandomized controlled trialMechanism

    In male social drinkers, intranasal oxytocin reduced thalamo-occipital connectivity during an alcohol cue-reactivity task.

    In plain wordsIn male social drinkers, nasal oxytocin reduced thalamo-occipital brain connectivity while they viewed alcohol cues.

    Peptide
    Oxytocin
    Outcome
    DecreaseThalamo-occipital connectivity during alcohol cues
    Study

    n = 13

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin application significantly reduced NAc connectivity with the cuneus and thalamo-occipital connectivity, while enhancing connectivity between the paracingulate gyrus and precentral gyrus.
    1 context sentence
    Summary · context
    Thirteen male social drinkers participated in a randomized double-blind placebo-controlled cross-over functional magnetic resonance imaging (fMRI) alcohol cue-reactivity task with and without prior intranasal application of 24 IU oxytocin.
  3. 03HumanRandomized controlled trialMechanism

    In male social drinkers, intranasal oxytocin enhanced connectivity between the paracingulate gyrus and precentral gyrus during an alcohol cue-reactivity task.

    In plain wordsIn male social drinkers, nasal oxytocin increased connectivity between two brain regions, the paracingulate and precentral gyri, while they viewed alcohol cues.

    Peptide
    Oxytocin
    Outcome
    IncreaseParacingulate gyrus to precentral gyrus connectivity during alcohol cues
    Study

    n = 13

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin application significantly reduced NAc connectivity with the cuneus and thalamo-occipital connectivity, while enhancing connectivity between the paracingulate gyrus and precentral gyrus.
    1 context sentence
    Summary · context
    Thirteen male social drinkers participated in a randomized double-blind placebo-controlled cross-over functional magnetic resonance imaging (fMRI) alcohol cue-reactivity task with and without prior intranasal application of 24 IU oxytocin.
  4. 04HumanRandomized controlled trialMechanism

    In male social drinkers, the oxytocin effect on connectivity was specific to alcohol cues and was not found during processing of neutral pictures.

    In plain wordsIn male social drinkers, the oxytocin effect on brain connectivity appeared with alcohol pictures but not with neutral pictures.

    Peptide
    Oxytocin
    Outcome
    No significant changeConnectivity change during neutral pictures
    Study

    n = 13

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    This effect was specific to the alcohol presentation and was not found during processing of neutral pictures.
    1 context sentence
    Summary · context
    Thirteen male social drinkers participated in a randomized double-blind placebo-controlled cross-over functional magnetic resonance imaging (fMRI) alcohol cue-reactivity task with and without prior intranasal application of 24 IU oxytocin.
  5. 05HumanRandomized controlled trialMechanism

    In male social drinkers, nucleus accumbens-cuneus connectivity correlated significantly with alcohol cue-induced craving during scanning.

    In plain wordsIn male social drinkers, this brain connectivity measure was linked to craving for alcohol during scanning.

    Peptide
    Oxytocin
    Outcome
    Not applicableCorrelation of NAc-cuneus connectivity with alcohol cue-induced craving
    Study

    n = 13

    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    In addition, the NAc-cuneus connectivity significantly correlated with alcohol cue-induced craving during the scanning session.
    1 context sentence
    Summary · context
    Thirteen male social drinkers participated in a randomized double-blind placebo-controlled cross-over functional magnetic resonance imaging (fMRI) alcohol cue-reactivity task with and without prior intranasal application of 24 IU oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.