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Study · Animal study (in vivo) · rat · 2019

12 results

Effects of noopept on cognitive functions and pubertal process in rats with diabetes.

Gürbüz P, Düzova H, Yildiz A, Çakan P, Kaya GB, Bağ HGG, Durhan M, Gül CC, Taşlidere AÇ

Life sciences26 Jul 2019Cited by 3 (Europe PMC)

PMID31356906 (opens in a new tab)DOI10.1016/j.lfs.2019.116698 (opens in a new tab)PepBankPUB-31356906
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In insulin-treated diabetic rats, adding Noopept decreased HOMA-IR.

    In plain wordsIn rats with diabetes, adding Noopept to insulin reduced insulin resistance compared with insulin alone.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseHOMA-IR
    Study

    ratn: not reported in source

    Streptozotocin-induced pubertal diabetes
    Comparator
    Insulin without Noopept
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    0.5 mg/kg · intraperitoneal · 14 daysAs given in this study (rat).

    Source sentences

    Summary
    Noopept decreased HOMA-IR in insulin administered diabetic group (p < 0.05).
    3 context sentences
    Summary · context
    The research was made with 60 prepubertal, 28 day-old, male, Sprague Dawley rats.
    Summary · context
    The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept.
    Summary · context
    0.5 mg/kg noopept and 1 IU insulin were administered intraperitoneally for 14 days.

Studies that did not test the peptide alone11

In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Noopept (omberacetam).

  1. 02AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Efficacy outcome

    In rats, kisspeptin did not differ among groups, including Noopept regimens and controls.

    In plain wordsIn rats, kisspeptin did not differ among groups, including Noopept regimens and controls.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeKisspeptin
    Study

    ratn = 60

    Streptozotocin-induced pubertal diabetes
    Comparator
    All groups
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    There was no difference in kisspeptin, serum LH, FSH, hippocampal NGF-BDNF levels and spatial learning assessment among groups (p > 0.05).
    3 context sentences
    Summary · context
    The research was made with 60 prepubertal, 28 day-old, male, Sprague Dawley rats.
    Summary · context
    The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept.
    Summary · context
    0.5 mg/kg noopept and 1 IU insulin were administered intraperitoneally for 14 days.

    In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).

  2. 03AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Efficacy outcome

    In rats, serum LH did not differ among groups, including Noopept regimens and controls.

    In plain wordsIn rats, serum LH did not differ among groups, including Noopept regimens and controls.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeSerum LH
    Study

    ratn = 60

    Streptozotocin-induced pubertal diabetes
    Comparator
    All groups
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    There was no difference in kisspeptin, serum LH, FSH, hippocampal NGF-BDNF levels and spatial learning assessment among groups (p > 0.05).
    3 context sentences
    Summary · context
    The research was made with 60 prepubertal, 28 day-old, male, Sprague Dawley rats.
    Summary · context
    The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept.
    Summary · context
    0.5 mg/kg noopept and 1 IU insulin were administered intraperitoneally for 14 days.

    In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).

  3. 04AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Efficacy outcome

    In rats, serum FSH did not differ among groups, including Noopept regimens and controls.

    In plain wordsIn rats, serum FSH did not differ among groups, including Noopept regimens and controls.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeSerum FSH
    Study

    ratn = 60

    Streptozotocin-induced pubertal diabetes
    Comparator
    All groups
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    There was no difference in kisspeptin, serum LH, FSH, hippocampal NGF-BDNF levels and spatial learning assessment among groups (p > 0.05).
    3 context sentences
    Summary · context
    The research was made with 60 prepubertal, 28 day-old, male, Sprague Dawley rats.
    Summary · context
    The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept.
    Summary · context
    0.5 mg/kg noopept and 1 IU insulin were administered intraperitoneally for 14 days.

    In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).

  4. 05AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Efficacy outcome

    In rats, hippocampal NGF did not differ among groups, including Noopept regimens and controls.

    In plain wordsIn rats, hippocampal NGF did not differ among groups, including Noopept regimens and controls.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeHippocampal NGF
    Study

    ratn = 60

    Streptozotocin-induced pubertal diabetes
    Comparator
    All groups
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    There was no difference in kisspeptin, serum LH, FSH, hippocampal NGF-BDNF levels and spatial learning assessment among groups (p > 0.05).
    3 context sentences
    Summary · context
    The research was made with 60 prepubertal, 28 day-old, male, Sprague Dawley rats.
    Summary · context
    The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept.
    Summary · context
    0.5 mg/kg noopept and 1 IU insulin were administered intraperitoneally for 14 days.

    In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).

  5. 06AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Efficacy outcome

    In rats, hippocampal BDNF did not differ among groups, including Noopept regimens and controls.

    In plain wordsIn rats, hippocampal BDNF did not differ among groups, including Noopept regimens and controls.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeHippocampal BDNF
    Study

    ratn = 60

    Streptozotocin-induced pubertal diabetes
    Comparator
    All groups
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    There was no difference in kisspeptin, serum LH, FSH, hippocampal NGF-BDNF levels and spatial learning assessment among groups (p > 0.05).
    3 context sentences
    Summary · context
    The research was made with 60 prepubertal, 28 day-old, male, Sprague Dawley rats.
    Summary · context
    The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept.
    Summary · context
    0.5 mg/kg noopept and 1 IU insulin were administered intraperitoneally for 14 days.

    In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).

  6. 07AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Efficacy outcome

    In rats, spatial learning did not differ among groups, including Noopept regimens and controls.

    In plain wordsIn rats, spatial learning did not differ among groups, including Noopept regimens and controls.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeSpatial learning
    Study

    ratn = 60

    Streptozotocin-induced pubertal diabetes
    Comparator
    All groups
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    There was no difference in kisspeptin, serum LH, FSH, hippocampal NGF-BDNF levels and spatial learning assessment among groups (p > 0.05).
    3 context sentences
    Summary · context
    The research was made with 60 prepubertal, 28 day-old, male, Sprague Dawley rats.
    Summary · context
    The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept.
    Summary · context
    0.5 mg/kg noopept and 1 IU insulin were administered intraperitoneally for 14 days.

    In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).

  7. 08AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Efficacy outcome

    In diabetic rats, Noopept regimens normalized delayed puberty.

    In plain wordsIn rats with diabetes, Noopept regimens normalized delayed puberty.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseDelayed puberty
    Study

    ratn: not reported in source

    Streptozotocin-induced pubertal diabetes
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Delayed puberty was normalized by noopept (p < 0.05).
    3 context sentences
    Summary · context
    The research was made with 60 prepubertal, 28 day-old, male, Sprague Dawley rats.
    Summary · context
    The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept.
    Summary · context
    0.5 mg/kg noopept and 1 IU insulin were administered intraperitoneally for 14 days.

    In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).

  8. 09AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Efficacy outcome

    In diabetic rats, blood glucose was lower in Noopept-treated groups, including an insulin combination group.

    In plain wordsIn rats with diabetes, blood glucose was lower in Noopept-treated groups, including an insulin combination group.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseBlood glucose
    Study

    ratn: not reported in source

    Streptozotocin-induced pubertal diabetes
    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    Blood glucose levels were lower in noopept-administered diabetic groups (p < 0.05).
    3 context sentences
    Summary · context
    The research was made with 60 prepubertal, 28 day-old, male, Sprague Dawley rats.
    Summary · context
    The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept.
    Summary · context
    0.5 mg/kg noopept and 1 IU insulin were administered intraperitoneally for 14 days.

    In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).

  9. 10AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Efficacy outcome

    In rats, hippocampal degeneration was lower in other groups, including Noopept regimens, than in diabetes controls.

    In plain wordsIn rats, hippocampal degeneration was lower in other groups, including Noopept regimens, than in diabetes controls.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseHippocampal degenerated cells
    Study

    ratn: not reported in source

    Streptozotocin-induced pubertal diabetes
    Comparator
    Diabetes control
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Number of degenerated cells in hippocampus and testis were higher in diabetes control group when compared with other groups (p < 0.05).
    3 context sentences
    Summary · context
    The research was made with 60 prepubertal, 28 day-old, male, Sprague Dawley rats.
    Summary · context
    The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept.
    Summary · context
    0.5 mg/kg noopept and 1 IU insulin were administered intraperitoneally for 14 days.

    In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).

  10. 11AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Efficacy outcome

    In rats, testicular degeneration was lower in other groups, including Noopept regimens, than in diabetes controls.

    In plain wordsIn rats, testicular degeneration was lower in other groups, including Noopept regimens, than in diabetes controls.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseTesticular degenerated cells
    Study

    ratn: not reported in source

    Streptozotocin-induced pubertal diabetes
    Comparator
    Diabetes control
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Number of degenerated cells in hippocampus and testis were higher in diabetes control group when compared with other groups (p < 0.05).
    3 context sentences
    Summary · context
    The research was made with 60 prepubertal, 28 day-old, male, Sprague Dawley rats.
    Summary · context
    The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept.
    Summary · context
    0.5 mg/kg noopept and 1 IU insulin were administered intraperitoneally for 14 days.

    In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).

  11. 12AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Efficacy outcome

    In diabetic rats, GnRH immunoreactivity was higher with Noopept alone than with insulin plus Noopept.

    In plain wordsIn rats with diabetes, GnRH immunoreactivity was higher with Noopept alone than with insulin plus Noopept.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseGnRH immunoreactivity
    Study

    ratn: not reported in source

    Streptozotocin-induced pubertal diabetes
    Comparator
    Insulin plus Noopept
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    GnRH immunoreactivity in Diabetes + Noopept group was increased when compared to insulin + noopept group (p = 0.018).
    3 context sentences
    Summary · context
    The research was made with 60 prepubertal, 28 day-old, male, Sprague Dawley rats.
    Summary · context
    The rats were divided into randomised 6 groups (n = 10/group). i) Control, ii) Diabetes Control, iii) Noopept Control, iv) Diabetes + Noopept, v) Diabetes + Insulin, vi) Diabetes + Insulin + Noopept.
    Summary · context
    0.5 mg/kg noopept and 1 IU insulin were administered intraperitoneally for 14 days.

    In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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