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Study · Randomized controlled trial · n = 100 · 2019

6 results

The effect of oxytocin administration on empathy and emotion recognition in residential youth: A randomized, within-subjects trial.

Fragkaki I, Cima M

Hormones and behavior30 Jul 2019Cited by 8 (Europe PMC)

PMID31351105 (opens in a new tab)DOI10.1016/j.yhbeh.2019.104561 (opens in a new tab)PepBankPUB-31351105
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In male adolescents in residential youth care, intranasal oxytocin increased empathy compared with placebo.

    In plain wordsIn male adolescents in residential care, nasal oxytocin raised empathy more than placebo did.

    Peptide
    Oxytocin
    Outcome
    IncreaseEmpathy after oxytocin versus placebo
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single dose per sessionAs given in this study (human).

    Source sentences

    Summary
    We found that empathy was increased after oxytocin administration compared to placebo and this effect was specific to individuals with high callous-unemotional traits.
    2 context sentences
    Summary · context
    We conducted a randomized, double-blind, placebo-controlled, within-subjects, sequential study to examine the effect of OT-IN on empathy and emotion recognition in 100 male adolescents living in residential youth care facilities.
    Summary · context
    Participants self-administered one dose of 24 IU of oxytocin or placebo and performed experimental tasks on empathy and emotion recognition before and after the administration.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In male adolescents in residential youth care, intranasal oxytocin had no effect on overall emotion recognition compared with placebo.

    In plain wordsIn male adolescents in residential care, nasal oxytocin did not change overall emotion recognition compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeOverall emotion recognition
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single dose per sessionAs given in this study (human).

    Source sentences

    Summary
    There was no effect of OT-IN on the overall emotion recognition
    2 context sentences
    Summary · context
    We conducted a randomized, double-blind, placebo-controlled, within-subjects, sequential study to examine the effect of OT-IN on empathy and emotion recognition in 100 male adolescents living in residential youth care facilities.
    Summary · context
    Participants self-administered one dose of 24 IU of oxytocin or placebo and performed experimental tasks on empathy and emotion recognition before and after the administration.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In male adolescents in residential youth care, intranasal oxytocin improved accuracy of fear recognition compared with placebo.

    In plain wordsIn male adolescents in residential care, nasal oxytocin improved recognition of fear more than placebo did.

    Peptide
    Oxytocin
    Outcome
    IncreaseAccuracy of fear recognition
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single dose per sessionAs given in this study (human).

    Source sentences

    Summary
    positive effect on accuracy of fear recognition.
    2 context sentences
    Summary · context
    We conducted a randomized, double-blind, placebo-controlled, within-subjects, sequential study to examine the effect of OT-IN on empathy and emotion recognition in 100 male adolescents living in residential youth care facilities.
    Summary · context
    Participants self-administered one dose of 24 IU of oxytocin or placebo and performed experimental tasks on empathy and emotion recognition before and after the administration.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In male adolescents in residential youth care, trauma did not moderate the effect of oxytocin on empathy or emotion recognition.

    In plain wordsIn male adolescents in residential care, past trauma did not change how oxytocin affected empathy or emotion recognition.

    Peptide
    Oxytocin
    Outcome
    No significant changeModeration of oxytocin effect by trauma
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single dose per sessionAs given in this study (human).

    Source sentences

    Summary
    Trauma and dissociation did not moderate the oxytocin effect on empathy or emotion recognition.
    2 context sentences
    Summary · context
    We conducted a randomized, double-blind, placebo-controlled, within-subjects, sequential study to examine the effect of OT-IN on empathy and emotion recognition in 100 male adolescents living in residential youth care facilities.
    Summary · context
    Participants self-administered one dose of 24 IU of oxytocin or placebo and performed experimental tasks on empathy and emotion recognition before and after the administration.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In male adolescents in residential youth care, dissociation did not moderate the effect of oxytocin on empathy or emotion recognition.

    In plain wordsIn male adolescents in residential care, dissociation did not change how oxytocin affected empathy or emotion recognition.

    Peptide
    Oxytocin
    Outcome
    No significant changeModeration of oxytocin effect by dissociation
    Study

    n = 100

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single dose per sessionAs given in this study (human).

    Source sentences

    Summary
    Trauma and dissociation did not moderate the oxytocin effect on empathy or emotion recognition.
    2 context sentences
    Summary · context
    We conducted a randomized, double-blind, placebo-controlled, within-subjects, sequential study to examine the effect of OT-IN on empathy and emotion recognition in 100 male adolescents living in residential youth care facilities.
    Summary · context
    Participants self-administered one dose of 24 IU of oxytocin or placebo and performed experimental tasks on empathy and emotion recognition before and after the administration.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In male adolescents in residential youth care, the oxytocin-induced increase in empathy was specific to those with high callous-unemotional traits.

    In plain wordsIn male adolescents in residential care, the empathy gain with oxytocin was found only in those with high callous-unemotional traits.

    Peptide
    Oxytocin
    Outcome
    IncreaseEmpathy in youth with high callous-unemotional traits
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single dose per sessionAs given in this study (human).

    Source sentences

    Summary
    We found that empathy was increased after oxytocin administration compared to placebo and this effect was specific to individuals with high callous-unemotional traits.
    2 context sentences
    Summary · context
    We conducted a randomized, double-blind, placebo-controlled, within-subjects, sequential study to examine the effect of OT-IN on empathy and emotion recognition in 100 male adolescents living in residential youth care facilities.
    Summary · context
    Participants self-administered one dose of 24 IU of oxytocin or placebo and performed experimental tasks on empathy and emotion recognition before and after the administration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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