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Study · Animal study (in vivo) · mouse · 2019

10 results

First evidence of protective effects on stroke recovery and post-stroke depression induced by sortilin-derived peptides.

Pietri M, Djillani A, Mazella J, Borsotto M, Heurteaux C

Neuropharmacology17 Jul 2019Cited by 13 (Europe PMC)

PMID31325429 (opens in a new tab)DOI10.1016/j.neuropharm.2019.107715 (opens in a new tab)PepBankPUB-31325429
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with focal ischemia, mini-spadin prevented the loss of body weight.

    In plain wordsIn mice with stroke, mini-spadin prevented the loss of body weight.

    Peptide
    PE 22-28
    Outcome
    DecreaseIschemia-induced body weight loss
    Study

    mousen: not reported in source

    focal ischemia and post-stroke depression
    Outcome group
    Body weight · Whole body
    Studied dose
    0.03 μg/kg once a day, or 3 μg/kg once a day · intraperitoneal · 7 days post-ischemia (0.03 μg/kg); 4 days/week until sacrifice (3 μg/kg)As given in this study (mouse).

    Source sentences

    Summary
    Mini-spadin prevented the loss of body weight and the delayed dopaminergic degeneration in substantia nigra and improved the motor and cognitive ischemia-induced deficits.
    3 context sentences
    Summary · context
    We investigated the therapeutic effects of mini-spadin in a mouse model of focal ischemia and PSD.
    Summary · context
    To activate TREK-1 and induce neuroprotection a single low dose of mini-spadin (0.03 μg/kg) was intraperitoneally injected 30  min after the onset of ischemia, once a day during 7 days post-ischemia.
    Summary · context
    Then, to inhibit TREK-1 and induce antidepressant effect, the peptide was injected at higher concentration (3 μg/kg) once a day for 4 days/week until the sacrifice of animals.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with focal ischemia, mini-spadin prevented the delayed dopaminergic degeneration in the substantia nigra.

    In plain wordsIn mice with stroke, mini-spadin prevented the later loss of dopamine-producing nerve cells in the substantia nigra.

    Peptide
    PE 22-28
    Outcome
    DecreaseDelayed dopaminergic degeneration in substantia nigra
    Study

    mousen: not reported in source

    focal ischemia and post-stroke depression
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.03 μg/kg once a day, or 3 μg/kg once a day · intraperitoneal · 7 days post-ischemia (0.03 μg/kg); 4 days/week until sacrifice (3 μg/kg)As given in this study (mouse).

    Source sentences

    Summary
    Mini-spadin prevented the loss of body weight and the delayed dopaminergic degeneration in substantia nigra and improved the motor and cognitive ischemia-induced deficits.
    3 context sentences
    Summary · context
    We investigated the therapeutic effects of mini-spadin in a mouse model of focal ischemia and PSD.
    Summary · context
    To activate TREK-1 and induce neuroprotection a single low dose of mini-spadin (0.03 μg/kg) was intraperitoneally injected 30  min after the onset of ischemia, once a day during 7 days post-ischemia.
    Summary · context
    Then, to inhibit TREK-1 and induce antidepressant effect, the peptide was injected at higher concentration (3 μg/kg) once a day for 4 days/week until the sacrifice of animals.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with focal ischemia, mini-spadin improved the ischemia-induced motor deficits.

    In plain wordsIn mice with stroke, mini-spadin improved movement problems caused by the stroke.

    Peptide
    PE 22-28
    Outcome
    DecreaseIschemia-induced motor deficits
    Study

    mousen: not reported in source

    focal ischemia and post-stroke depression
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.03 μg/kg once a day, or 3 μg/kg once a day · intraperitoneal · 7 days post-ischemia (0.03 μg/kg); 4 days/week until sacrifice (3 μg/kg)As given in this study (mouse).

    Source sentences

    Summary
    Mini-spadin prevented the loss of body weight and the delayed dopaminergic degeneration in substantia nigra and improved the motor and cognitive ischemia-induced deficits.
    3 context sentences
    Summary · context
    We investigated the therapeutic effects of mini-spadin in a mouse model of focal ischemia and PSD.
    Summary · context
    To activate TREK-1 and induce neuroprotection a single low dose of mini-spadin (0.03 μg/kg) was intraperitoneally injected 30  min after the onset of ischemia, once a day during 7 days post-ischemia.
    Summary · context
    Then, to inhibit TREK-1 and induce antidepressant effect, the peptide was injected at higher concentration (3 μg/kg) once a day for 4 days/week until the sacrifice of animals.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with focal ischemia, mini-spadin improved the ischemia-induced cognitive deficits.

    In plain wordsIn mice with stroke, mini-spadin improved thinking and memory problems caused by the stroke.

    Peptide
    PE 22-28
    Outcome
    DecreaseIschemia-induced cognitive deficits
    Study

    mousen: not reported in source

    focal ischemia and post-stroke depression
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.03 μg/kg once a day, or 3 μg/kg once a day · intraperitoneal · 7 days post-ischemia (0.03 μg/kg); 4 days/week until sacrifice (3 μg/kg)As given in this study (mouse).

    Source sentences

    Summary
    Mini-spadin prevented the loss of body weight and the delayed dopaminergic degeneration in substantia nigra and improved the motor and cognitive ischemia-induced deficits.
    3 context sentences
    Summary · context
    We investigated the therapeutic effects of mini-spadin in a mouse model of focal ischemia and PSD.
    Summary · context
    To activate TREK-1 and induce neuroprotection a single low dose of mini-spadin (0.03 μg/kg) was intraperitoneally injected 30  min after the onset of ischemia, once a day during 7 days post-ischemia.
    Summary · context
    Then, to inhibit TREK-1 and induce antidepressant effect, the peptide was injected at higher concentration (3 μg/kg) once a day for 4 days/week until the sacrifice of animals.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with focal ischemia, mini-spadin prevented post-stroke depression as analyzed in the Forced Swim Test.

    In plain wordsIn mice with stroke, mini-spadin prevented depression-like behavior in the forced swim test.

    Peptide
    PE 22-28
    Outcome
    DecreasePost-stroke depression in the Forced Swim Test
    Study

    mousen: not reported in source

    focal ischemia and post-stroke depression
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.03 μg/kg once a day, or 3 μg/kg once a day · intraperitoneal · 7 days post-ischemia (0.03 μg/kg); 4 days/week until sacrifice (3 μg/kg)As given in this study (mouse).

    Source sentences

    Summary
    Moreover, mini-spadin prevented PSD analyzed in the Forced Swim (FST) and Novelty Suppressed Feeding (NSF) tests.
    3 context sentences
    Summary · context
    We investigated the therapeutic effects of mini-spadin in a mouse model of focal ischemia and PSD.
    Summary · context
    To activate TREK-1 and induce neuroprotection a single low dose of mini-spadin (0.03 μg/kg) was intraperitoneally injected 30  min after the onset of ischemia, once a day during 7 days post-ischemia.
    Summary · context
    Then, to inhibit TREK-1 and induce antidepressant effect, the peptide was injected at higher concentration (3 μg/kg) once a day for 4 days/week until the sacrifice of animals.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with focal ischemia, mini-spadin prevented post-stroke depression as analyzed in the Novelty Suppressed Feeding test.

    In plain wordsIn mice with stroke, mini-spadin prevented depression-like behavior in the novelty suppressed feeding test.

    Peptide
    PE 22-28
    Outcome
    DecreasePost-stroke depression in the Novelty Suppressed Feeding test
    Study

    mousen: not reported in source

    focal ischemia and post-stroke depression
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.03 μg/kg once a day, or 3 μg/kg once a day · intraperitoneal · 7 days post-ischemia (0.03 μg/kg); 4 days/week until sacrifice (3 μg/kg)As given in this study (mouse).

    Source sentences

    Summary
    Moreover, mini-spadin prevented PSD analyzed in the Forced Swim (FST) and Novelty Suppressed Feeding (NSF) tests.
    3 context sentences
    Summary · context
    We investigated the therapeutic effects of mini-spadin in a mouse model of focal ischemia and PSD.
    Summary · context
    To activate TREK-1 and induce neuroprotection a single low dose of mini-spadin (0.03 μg/kg) was intraperitoneally injected 30  min after the onset of ischemia, once a day during 7 days post-ischemia.
    Summary · context
    Then, to inhibit TREK-1 and induce antidepressant effect, the peptide was injected at higher concentration (3 μg/kg) once a day for 4 days/week until the sacrifice of animals.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with focal ischemia and post-stroke depression, enhanced neurogenesis contributed to the beneficial effects of mini-spadin.

    In plain wordsIn mice with stroke, new nerve cell growth contributed to the benefits of mini-spadin.

    Peptide
    PE 22-28
    Outcome
    IncreaseNeurogenesis
    Study

    mousen: not reported in source

    focal ischemia and post-stroke depression
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.03 μg/kg once a day, or 3 μg/kg once a day · intraperitoneal · 7 days post-ischemia (0.03 μg/kg); 4 days/week until sacrifice (3 μg/kg)As given in this study (mouse).

    Source sentences

    Summary
    Finally, enhanced neurogenesis and synaptogenesis contributed to the beneficial effects of mini-spadin against stroke and PSD.
    3 context sentences
    Summary · context
    We investigated the therapeutic effects of mini-spadin in a mouse model of focal ischemia and PSD.
    Summary · context
    To activate TREK-1 and induce neuroprotection a single low dose of mini-spadin (0.03 μg/kg) was intraperitoneally injected 30  min after the onset of ischemia, once a day during 7 days post-ischemia.
    Summary · context
    Then, to inhibit TREK-1 and induce antidepressant effect, the peptide was injected at higher concentration (3 μg/kg) once a day for 4 days/week until the sacrifice of animals.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with focal ischemia and post-stroke depression, enhanced synaptogenesis contributed to the beneficial effects of mini-spadin.

    In plain wordsIn mice with stroke, new nerve connection growth contributed to the benefits of mini-spadin.

    Peptide
    PE 22-28
    Outcome
    IncreaseSynaptogenesis
    Study

    mousen: not reported in source

    focal ischemia and post-stroke depression
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.03 μg/kg once a day, or 3 μg/kg once a day · intraperitoneal · 7 days post-ischemia (0.03 μg/kg); 4 days/week until sacrifice (3 μg/kg)As given in this study (mouse).

    Source sentences

    Summary
    Finally, enhanced neurogenesis and synaptogenesis contributed to the beneficial effects of mini-spadin against stroke and PSD.
    3 context sentences
    Summary · context
    We investigated the therapeutic effects of mini-spadin in a mouse model of focal ischemia and PSD.
    Summary · context
    To activate TREK-1 and induce neuroprotection a single low dose of mini-spadin (0.03 μg/kg) was intraperitoneally injected 30  min after the onset of ischemia, once a day during 7 days post-ischemia.
    Summary · context
    Then, to inhibit TREK-1 and induce antidepressant effect, the peptide was injected at higher concentration (3 μg/kg) once a day for 4 days/week until the sacrifice of animals.
  9. 09LabIn vitro (cells)Activity measurement

    In electrophysiological studies, mini-spadin at low doses increased TREK-1 channel activity.

    In plain wordsIn lab tests, low doses of mini-spadin increased the activity of the TREK-1 channel.

    Peptide
    PE 22-28
    Outcome
    IncreaseTREK-1 channel activity at low doses
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At low doses, the channel activity was increased
    1 context sentence
    Summary · context
    Electrophysiological studies showed that mini-spadin had a biphasic action on TREK-1.
  10. 10LabIn vitro (cells)Activity measurement

    In electrophysiological studies, mini-spadin at higher doses inhibited TREK-1 channel activity.

    In plain wordsIn lab tests, higher doses of mini-spadin blocked the activity of the TREK-1 channel.

    Peptide
    PE 22-28
    Outcome
    DecreaseTREK-1 channel activity at higher doses
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    at higher doses it was inhibited.
    1 context sentence
    Summary · context
    Electrophysiological studies showed that mini-spadin had a biphasic action on TREK-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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