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Study · Animal study (in vivo) · mouse · 2019

3 results

The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity.

Kim SJ, Miller B, Mehta HH, Xiao J, Wan J, Arpawong TE, Yen K, Cohen P

Physiological reports1 Jul 2019Cited by 53 (Europe PMC)

PMID31293078 (opens in a new tab)PMCIDPMC6640593 (opens in a new tab)DOI10.14814/phy2.14171 (opens in a new tab)PepBankPUB-31293078
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Summary

MOTS-c is an exercise mimetic and improves insulin sensitivity in aged and diet-induced obese mice. Although plasma markers are good markers for the metabolic condition, whether MOTS-c changes plasma markers in diet-induced obese mice has not been examined. Here, we used an unbiased metabolomics approach to examine the effect of MOTS-c on plasma markers of metabolic dysfunction. We found that three pathways - sphingolipid metabolism, monoacylglycerol metabolism, and dicarboxylate metabolism - were reduced in MOTS-c-injected mice. Interestingly, these pathways are upregulated in obese and T2D models. MOTS-c improves insulin sensitivity and increases beta-oxidation to prevent fat accumulation in DIO mice through these pathways. These results provide us a better understanding of the mechanism of how MOTS-c improves insulin sensitivity and reduces the body weight and fatty liver and opens a new venue for further study.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In diet-induced obese mice, the plasma sphingolipid metabolism pathway was reduced in MOTS‑c-injected mice.

    In plain wordsIn obese mice, MOTS‑c injection lowered a plasma fat-metabolism pathway (sphingolipid) that is raised in obesity and type 2 diabetes models.

    Peptide
    MOTS-c
    Outcome
    DecreaseSphingolipid metabolism pathway in plasma
    Study

    mousen: not reported in source

    Diet-induced obese mice
    Outcome group
    Metabolic pathways and metabolomics · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that three pathways - sphingolipid metabolism, monoacylglycerol metabolism, and dicarboxylate metabolism - were reduced in MOTS-c-injected mice.
    1 context sentence
    Summary · context
    Here, we used an unbiased metabolomics approach to examine the effect of MOTS-c on plasma markers of metabolic dysfunction.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In diet-induced obese mice, the plasma monoacylglycerol metabolism pathway was reduced in MOTS‑c-injected mice.

    In plain wordsIn obese mice, MOTS‑c injection lowered a plasma fat-metabolism pathway (monoacylglycerol) that is raised in obesity and type 2 diabetes models.

    Peptide
    MOTS-c
    Outcome
    DecreaseMonoacylglycerol metabolism pathway in plasma
    Study

    mousen: not reported in source

    Diet-induced obese mice
    Outcome group
    Metabolic pathways and metabolomics · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that three pathways - sphingolipid metabolism, monoacylglycerol metabolism, and dicarboxylate metabolism - were reduced in MOTS-c-injected mice.
    1 context sentence
    Summary · context
    Here, we used an unbiased metabolomics approach to examine the effect of MOTS-c on plasma markers of metabolic dysfunction.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In diet-induced obese mice, the plasma dicarboxylate metabolism pathway was reduced in MOTS‑c-injected mice.

    In plain wordsIn obese mice, MOTS‑c injection lowered a plasma metabolism pathway (dicarboxylate) that is raised in obesity and type 2 diabetes models.

    Peptide
    MOTS-c
    Outcome
    DecreaseDicarboxylate metabolism pathway in plasma
    Study

    mousen: not reported in source

    Diet-induced obese mice
    Outcome group
    Metabolic pathways and metabolomics · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that three pathways - sphingolipid metabolism, monoacylglycerol metabolism, and dicarboxylate metabolism - were reduced in MOTS-c-injected mice.
    1 context sentence
    Summary · context
    Here, we used an unbiased metabolomics approach to examine the effect of MOTS-c on plasma markers of metabolic dysfunction.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

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