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Study · Animal study (in vivo) · rat · 2019

5 results

Long-term Surgical and Chemical Castration Deteriorates Memory Function Through Downregulation of PKA/CREB/BDNF and c-Raf/MEK/ERK Pathways in Hippocampus.

Shin MS, Kim TW, Park SS, Ko IG, Kim CJ, Kim M, Roh SY, Kim KT, Kim KH

International neurourology journal30 Jun 2019Cited by 16 (Europe PMC)

PMID31260611 (opens in a new tab)PMCIDPMC6606934 (opens in a new tab)DOI10.5213/inj.1938103.052 (opens in a new tab)PepBankPUB-31260611
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, goserelin chemical castration reduced neurogenesis.

    In plain wordsIn rats, goserelin chemical castration reduced the formation of new nerve cells.

    Peptide
    Goserelin
    Outcome
    DecreaseNeurogenesis
    Study

    ratn: not reported in source

    Chemical castration
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The orchiectomy group and the goserelin group showed less neurogenesis and impaired short-term and spatial memory.
    2 context sentences
    Summary · context
    In a rat model, we investigated whether surgical and chemical castration affected memory ability
    Summary · context
    Orchiectomy was performed for surgical castration and goserelin acetate was subcutaneously transplanted into the anterior abdominal wall for chemical castration.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, goserelin chemical castration impaired short-term memory.

    In plain wordsIn rats, goserelin chemical castration impaired short-term memory.

    Peptide
    Goserelin
    Outcome
    DecreaseShort-term memory
    Study

    ratn: not reported in source

    Chemical castration
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The orchiectomy group and the goserelin group showed less neurogenesis and impaired short-term and spatial memory.
    2 context sentences
    Summary · context
    In a rat model, we investigated whether surgical and chemical castration affected memory ability
    Summary · context
    Orchiectomy was performed for surgical castration and goserelin acetate was subcutaneously transplanted into the anterior abdominal wall for chemical castration.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, goserelin chemical castration impaired spatial memory.

    In plain wordsIn rats, goserelin chemical castration impaired spatial memory.

    Peptide
    Goserelin
    Outcome
    DecreaseSpatial memory
    Study

    ratn: not reported in source

    Chemical castration
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The orchiectomy group and the goserelin group showed less neurogenesis and impaired short-term and spatial memory.
    2 context sentences
    Summary · context
    In a rat model, we investigated whether surgical and chemical castration affected memory ability
    Summary · context
    Orchiectomy was performed for surgical castration and goserelin acetate was subcutaneously transplanted into the anterior abdominal wall for chemical castration.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, goserelin chemical castration decreased PKA/CREB/BDNF phosphorylation.

    In plain wordsIn rats, goserelin chemical castration decreased phosphorylation in the PKA/CREB/BDNF pathway.

    Peptide
    Goserelin
    Outcome
    DecreasePKA/CREB/BDNF phosphorylation
    Study

    ratn: not reported in source

    Chemical castration
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Phosphorylation of PKA/CREB/BDNF and phosphorylation of c-Raf/MEK/ERK decreased in the orchiectomy and goserelin groups.
    2 context sentences
    Summary · context
    In a rat model, we investigated whether surgical and chemical castration affected memory ability
    Summary · context
    Orchiectomy was performed for surgical castration and goserelin acetate was subcutaneously transplanted into the anterior abdominal wall for chemical castration.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, goserelin chemical castration decreased c-Raf/MEK/ERK phosphorylation.

    In plain wordsIn rats, goserelin chemical castration decreased phosphorylation in the c-Raf/MEK/ERK pathway.

    Peptide
    Goserelin
    Outcome
    Decreasec-Raf/MEK/ERK phosphorylation
    Study

    ratn: not reported in source

    Chemical castration
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Phosphorylation of PKA/CREB/BDNF and phosphorylation of c-Raf/MEK/ERK decreased in the orchiectomy and goserelin groups.
    2 context sentences
    Summary · context
    In a rat model, we investigated whether surgical and chemical castration affected memory ability
    Summary · context
    Orchiectomy was performed for surgical castration and goserelin acetate was subcutaneously transplanted into the anterior abdominal wall for chemical castration.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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