Comparison of the intravenous and intravaginal route of oxytocin administration for cervical dilation protocol and non-surgical embryo recovery in oestrous-induced Santa Inês ewes.

Prellwitz L, Zambrini FN, Guimarães JD, de Sousa MAP, Oliveira MEF, Garcia AR, Esteves SN, Bartlewski PM, Souza-Fabjan JMG, Fonseca JF

Reproduction in domestic animals = Zuchthygiene25 Jul 2019Cited by 12 (Europe PMC)

PMID31243815DOI10.1111/rda.13499PepBankPUB-31243815

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In oestrous-induced ewes, intravaginal and intravenous oxytocin did not differ in non-surgical embryo recovery efficiency or ease of flushing.
In plain wordsIn ewes, oxytocin given in the vagina or into a vein worked equally well for embryo recovery.
Peptide
Oxytocin
Outcome
No significant changeEfficiency of non-surgical embryo recovery by oxytocin route
Study
sheepn = 42
oestrous-induced Santa Inês ewes
Comparator
Intravenous versus intravaginal oxytocin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
50 IU · intravenous or intravaginalAs given in this study (sheep).
Source sentences
Summary
The route of OT administration had no effect on NSER efficiency or the ease with which transcervical embryo flushing was performed.
2 context sentences(design, population, supporting numbers)
Summary · context
This study compared the effects of intravaginal and intravenous routes of oxytocin (OT) administration in 46 oestrous-induced Santa Inês ewes (6-day treatment with progestin-releasing intravaginal sponges and a single injection of 200 IU of eCG at the time of sponge removal) that underwent transcerv…
Summary · context
All ewes received 37.5 μg of d-cloprostenol via latero-vulvar route, and 1 mg of oestradiol benzoate i.m. 16 hr before and 50 IU of OT 20 min before non-surgical embryo recovery (NSER), with OT being administered intravenously (n = 21) or intravaginally (n = 21).
Report a problemFND-3124381501

Studies that did not test the peptide alone6

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In oestrous-induced ewes given a protocol of cloprostenol, oestradiol benzoate and oxytocin, adequate cervical retraction was reached in 78.6% (33/42).
In plain wordsIn ewes given a drug protocol that included oxytocin, the cervix could be retracted enough in most animals.
Peptide
Oxytocin
Outcome
Not applicableAdequate cervical retraction
Study
sheepn = 42
oestrous-induced Santa Inês ewes
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Adequate cervical retraction
78.6%
ewes
Source sentences
Summary
adequate cervical retraction could be accomplished in 78.6% (33/42) of ewes.
2 context sentences(design, population, supporting numbers)
Summary · context
This study compared the effects of intravaginal and intravenous routes of oxytocin (OT) administration in 46 oestrous-induced Santa Inês ewes (6-day treatment with progestin-releasing intravaginal sponges and a single injection of 200 IU of eCG at the time of sponge removal) that underwent transcerv…
Summary · context
All ewes received 37.5 μg of d-cloprostenol via latero-vulvar route, and 1 mg of oestradiol benzoate i.m. 16 hr before and 50 IU of OT 20 min before non-surgical embryo recovery (NSER), with OT being administered intravenously (n = 21) or intravaginally (n = 21).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-3124381502
03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In oestrous-induced ewes given a protocol of cloprostenol, oestradiol benzoate and oxytocin, 57% of embryo recovery procedures succeeded.
In plain wordsIn ewes given a drug protocol that included oxytocin, just over half of the embryo recovery procedures succeeded.
Peptide
Oxytocin
Outcome
Not applicableSuccess of non-surgical embryo recovery
Study
sheepn = 42
oestrous-induced Santa Inês ewes
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Successful NSER
57%
all ewes
Source sentences
Summary
The percentage of successful NSER procedures was 57% (24/42) or 72.7% (24/33) of animals with sufficient cervical retraction.
2 context sentences(design, population, supporting numbers)
Summary · context
This study compared the effects of intravaginal and intravenous routes of oxytocin (OT) administration in 46 oestrous-induced Santa Inês ewes (6-day treatment with progestin-releasing intravaginal sponges and a single injection of 200 IU of eCG at the time of sponge removal) that underwent transcerv…
Summary · context
All ewes received 37.5 μg of d-cloprostenol via latero-vulvar route, and 1 mg of oestradiol benzoate i.m. 16 hr before and 50 IU of OT 20 min before non-surgical embryo recovery (NSER), with OT being administered intravenously (n = 21) or intravaginally (n = 21).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-3124381503
04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In ewes with sufficient cervical retraction given a protocol of cloprostenol, oestradiol benzoate and oxytocin, 72.7% of embryo recovery procedures succeeded.
In plain wordsIn ewes given a drug protocol that included oxytocin, most procedures succeeded when the cervix retracted enough.
Peptide
Oxytocin
Outcome
Not applicableSuccess of non-surgical embryo recovery in ewes with sufficient cervical retraction
Study
sheepn = 33
oestrous-induced Santa Inês ewes
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Successful NSER
72.7%
ewes with sufficient cervical retraction
Source sentences
Summary
The percentage of successful NSER procedures was 57% (24/42) or 72.7% (24/33) of animals with sufficient cervical retraction.
2 context sentences(design, population, supporting numbers)
Summary · context
This study compared the effects of intravaginal and intravenous routes of oxytocin (OT) administration in 46 oestrous-induced Santa Inês ewes (6-day treatment with progestin-releasing intravaginal sponges and a single injection of 200 IU of eCG at the time of sponge removal) that underwent transcerv…
Summary · context
All ewes received 37.5 μg of d-cloprostenol via latero-vulvar route, and 1 mg of oestradiol benzoate i.m. 16 hr before and 50 IU of OT 20 min before non-surgical embryo recovery (NSER), with OT being administered intravenously (n = 21) or intravaginally (n = 21).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-3124381504
05AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In ewes without anatomical barriers given a protocol of cloprostenol, oestradiol benzoate and oxytocin, the overall success of embryo recovery was 80% (24/30).
In plain wordsIn ewes given a drug protocol that included oxytocin, embryo recovery succeeded in four of five animals without anatomical barriers.
Peptide
Oxytocin
Outcome
Not applicableSuccess of non-surgical embryo recovery excluding ewes with anatomical barriers
Study
sheepn = 30
oestrous-induced Santa Inês ewes
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Overall NSER success
80%
ewes without anatomical barriers
Source sentences
Summary
Excluding the ewes with those anatomical features, the overall success rate of NSER was 80% (24/30).
2 context sentences(design, population, supporting numbers)
Summary · context
This study compared the effects of intravaginal and intravenous routes of oxytocin (OT) administration in 46 oestrous-induced Santa Inês ewes (6-day treatment with progestin-releasing intravaginal sponges and a single injection of 200 IU of eCG at the time of sponge removal) that underwent transcerv…
Summary · context
All ewes received 37.5 μg of d-cloprostenol via latero-vulvar route, and 1 mg of oestradiol benzoate i.m. 16 hr before and 50 IU of OT 20 min before non-surgical embryo recovery (NSER), with OT being administered intravenously (n = 21) or intravaginally (n = 21).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-3124381505
06AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In ewes given a protocol of cloprostenol, oestradiol benzoate and oxytocin, about 96% of flushing fluid was recovered.
In plain wordsIn ewes given a drug protocol that included oxytocin, nearly all of the flushing fluid was recovered.
Peptide
Oxytocin
Outcome
Not applicableFlushing fluid recovery
Study
sheepn: not reported in source
oestrous-induced Santa Inês ewes
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
Flushing fluid recovered
≈ 96%
ewes
Source sentences
Summary
~96% of flushing fluid could be recovered (range: 85%-100%).
2 context sentences(design, population, supporting numbers)
Summary · context
This study compared the effects of intravaginal and intravenous routes of oxytocin (OT) administration in 46 oestrous-induced Santa Inês ewes (6-day treatment with progestin-releasing intravaginal sponges and a single injection of 200 IU of eCG at the time of sponge removal) that underwent transcerv…
Summary · context
All ewes received 37.5 μg of d-cloprostenol via latero-vulvar route, and 1 mg of oestradiol benzoate i.m. 16 hr before and 50 IU of OT 20 min before non-surgical embryo recovery (NSER), with OT being administered intravenously (n = 21) or intravaginally (n = 21).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-3124381506
07AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome
In ewes given a protocol of cloprostenol, oestradiol benzoate and oxytocin, the embryo recovery procedure lasted 28 min on average.
In plain wordsIn ewes given a drug protocol that included oxytocin, the embryo recovery procedure took about half an hour.
Peptide
Oxytocin
Outcome
Not applicableDuration of non-surgical embryo recovery
Study
sheepn: not reported in source
oestrous-induced Santa Inês ewes
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Measurements
NSER duration
28 min
ewes
Source sentences
Summary
The duration of NSER procedure averaged 28 min (range: 17-40 min)
2 context sentences(design, population, supporting numbers)
Summary · context
This study compared the effects of intravaginal and intravenous routes of oxytocin (OT) administration in 46 oestrous-induced Santa Inês ewes (6-day treatment with progestin-releasing intravaginal sponges and a single injection of 200 IU of eCG at the time of sponge removal) that underwent transcerv…
Summary · context
All ewes received 37.5 μg of d-cloprostenol via latero-vulvar route, and 1 mg of oestradiol benzoate i.m. 16 hr before and 50 IU of OT 20 min before non-surgical embryo recovery (NSER), with OT being administered intravenously (n = 21) or intravaginally (n = 21).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-3124381507

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:49 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Keywords

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