Oxytocin reduces top-down control of attention by increasing bottom-up attention allocation to social but not non-social stimuli - A randomized controlled trial.

Xu X, Li J, Chen Z, Kendrick KM, Becker B

Psychoneuroendocrinology15 Jun 2019Cited by 39 (Europe PMC)

PMID31229634DOI10.1016/j.psyneuen.2019.06.004PepBankPUB-31229634

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

01HumanRandomized controlled trialEfficacy outcome
In male volunteers, intranasal oxytocin increased antisaccade errors for social stimuli compared with placebo.
In plain wordsIn men, oxytocin nasal spray caused more eye-movement control errors with social images than placebo did.
Peptide
Oxytocin
Outcome
IncreaseAntisaccade errors for social stimuli
Study
n = 71
Comparator
Placebo
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
24 IU · intranasalAs given in this study (human).
Source sentences
Summary
Results revealed a marginal significant interaction effect between treatment, condition and task (p = 0.054), with Bonferroni-corrected post-hoc tests indicating that OXT specifically increased antisaccade errors for social stimuli (ps < 0.04, effect sizes 0.46-0.88), but not non-social stimuli.
1 context sentence(design, population, supporting numbers)
Summary · context
we therefore recruited 71 male subjects (OXT = 34, PLC = 37) to investigate the effects of intranasal OXT (24IU) on both bottom-up attention allocation and top-down attention inhibition using a prosaccade and antisaccade paradigm incorporating social (neutral, happy, fearful, sad, angry faces) and n…
Report a problemFND-3122963401
02HumanRandomized controlled trialEfficacy outcome
In male volunteers, intranasal oxytocin did not increase antisaccade errors for non-social stimuli compared with placebo.
In plain wordsIn men, oxytocin nasal spray did not change eye-movement control errors with non-social shapes compared with placebo.
Peptide
Oxytocin
Outcome
No significant changeAntisaccade errors for non-social stimuli
Study
n = 71
Comparator
Placebo
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
24 IU · intranasalAs given in this study (human).
Source sentences
Summary
Results revealed a marginal significant interaction effect between treatment, condition and task (p = 0.054), with Bonferroni-corrected post-hoc tests indicating that OXT specifically increased antisaccade errors for social stimuli (ps < 0.04, effect sizes 0.46-0.88), but not non-social stimuli.
1 context sentence(design, population, supporting numbers)
Summary · context
we therefore recruited 71 male subjects (OXT = 34, PLC = 37) to investigate the effects of intranasal OXT (24IU) on both bottom-up attention allocation and top-down attention inhibition using a prosaccade and antisaccade paradigm incorporating social (neutral, happy, fearful, sad, angry faces) and n…
Report a problemFND-3122963402
03HumanRandomized controlled trialEfficacy outcome
In male volunteers, the interaction between treatment, condition and task was only marginally significant (p = 0.054).
In plain wordsIn men, the overall oxytocin by task effect on eye movements was only borderline, compared with placebo.
Peptide
Oxytocin
Outcome
No significant changeTreatment by condition by task interaction
Study
n = 71
Comparator
Placebo
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
24 IU · intranasalAs given in this study (human).
Source sentences
Summary
Results revealed a marginal significant interaction effect between treatment, condition and task (p = 0.054), with Bonferroni-corrected post-hoc tests indicating that OXT specifically increased antisaccade errors for social stimuli (ps < 0.04, effect sizes 0.46-0.88), but not non-social stimuli.
1 context sentence(design, population, supporting numbers)
Summary · context
we therefore recruited 71 male subjects (OXT = 34, PLC = 37) to investigate the effects of intranasal OXT (24IU) on both bottom-up attention allocation and top-down attention inhibition using a prosaccade and antisaccade paradigm incorporating social (neutral, happy, fearful, sad, angry faces) and n…
Report a problemFND-3122963403

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · source ClinicalTrials.gov (opens in a new tab)

Status unknownNot applicableNCT05444738

Effects of Oxytocin Administered Orally Using a Medicated Lollipop on Peripheral Concentrations and Attention

University of Electronic Science and Technology of Chinan = 721 Apr 2022 to est. 30 Aug 2022

Healthy

Trial page ClinicalTrials.govUpdated 6 Jul 2022

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:49 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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