Cardioprotective effects of cerebrolysin on the lesion severity and inflammatory factors in a rat model of isoproterenol-induced myocardial injury.

Ardjmand A, Shahaboddin ME, Mazoochi T, Heydari A, Ghavipanjeh G

Pharmacological reports : PR16 Mar 2019Cited by 15 (Europe PMC)

PMID31201967DOI10.1016/j.pharep.2019.03.003PepBankPUB-31201967

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with myocardial injury, cerebrolysin treatment produced only a moderate reduction in inflammatory cell infiltration.
In plain wordsIn rats with heart injury, cerebrolysin produced only a moderate reduction in inflammatory cells.
Peptide
Cerebrolysin
Outcome
DecreaseInflammatory cell infiltration
Study
ratn: not reported in source
Isoproterenol-induced myocardial injury in male rats
Outcome group
Inflammation markers · Cardiovascular
Studied dose
5 ml/kg · intraperitoneal · 7 daysAs given in this study (rat).
Source sentences
Summary
Also, our findings showed only a moderate reduction in inflammatory cell infiltration and extent of edema following CLY treatment in the CLY + ISO group.
2 context sentences(design, population, supporting numbers)
Summary · context
The current study was designed to investigate the cardioprotective effects of cerebrolysin (CLY) on the lesion severity and inflammatory factors in male rats using isoproterenol (ISO)-induced MI model.
Summary · context
Then, CLY (5 ml/kg) was injected intraperitoneally (ip) post-treatment for 7 days.
Report a problemFND-3120196705
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with myocardial injury, cerebrolysin treatment produced only a moderate reduction in edema extent.
In plain wordsIn rats with heart injury, cerebrolysin produced only a moderate reduction in tissue swelling.
Peptide
Cerebrolysin
Outcome
DecreaseEdema extent
Study
ratn: not reported in source
Isoproterenol-induced myocardial injury in male rats
Outcome group
Heart function · Cardiovascular
Studied dose
5 ml/kg · intraperitoneal · 7 daysAs given in this study (rat).
Source sentences
Summary
Also, our findings showed only a moderate reduction in inflammatory cell infiltration and extent of edema following CLY treatment in the CLY + ISO group.
2 context sentences(design, population, supporting numbers)
Summary · context
The current study was designed to investigate the cardioprotective effects of cerebrolysin (CLY) on the lesion severity and inflammatory factors in male rats using isoproterenol (ISO)-induced MI model.
Summary · context
Then, CLY (5 ml/kg) was injected intraperitoneally (ip) post-treatment for 7 days.
Report a problemFND-3120196706
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with myocardial injury, cerebrolysin induced vascular proliferation in heart tissue.
In plain wordsIn rats with heart injury, cerebrolysin increased vascular proliferation in heart tissue.
Peptide
Cerebrolysin
Outcome
IncreaseVascular proliferation
Study
ratn: not reported in source
Isoproterenol-induced myocardial injury in male rats
Outcome group
Heart function · Cardiovascular
Studied dose
5 ml/kg · intraperitoneal · 7 daysAs given in this study (rat).
Source sentences
Summary
Also, CLY induced vascular proliferation in the heart tissue.
2 context sentences(design, population, supporting numbers)
Summary · context
The current study was designed to investigate the cardioprotective effects of cerebrolysin (CLY) on the lesion severity and inflammatory factors in male rats using isoproterenol (ISO)-induced MI model.
Summary · context
Then, CLY (5 ml/kg) was injected intraperitoneally (ip) post-treatment for 7 days.
Report a problemFND-3120196707

Studies that did not test the peptide alone4

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

04AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Other
In rats, serum CK-MB increased in both ISO and CLY + ISO groups versus control on the 3rd day.
In plain wordsIn rats, a heart injury marker increased with isoproterenol both with and without cerebrolysin compared with control.
Peptide
Cerebrolysin
Outcome
IncreaseSerum CK-MB on day 3
Study
ratn: not reported in source
Isoproterenol-induced myocardial injury in male rats
Comparator
Control
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
On the 3rd day, the serum CK-MB and cTnI levels in the ISO and CLY + ISO groups were significantly increased compared with that in the control and CLY + Sal groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The current study was designed to investigate the cardioprotective effects of cerebrolysin (CLY) on the lesion severity and inflammatory factors in male rats using isoproterenol (ISO)-induced MI model.
Summary · context
Then, CLY (5 ml/kg) was injected intraperitoneally (ip) post-treatment for 7 days.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3120196701
05AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Other
In rats, serum CK-MB increased in both ISO and CLY + ISO groups versus CLY + Sal on the 3rd day.
In plain wordsIn rats, a heart injury marker increased with isoproterenol both with and without cerebrolysin compared with cerebrolysin plus saline.
Peptide
Cerebrolysin
Outcome
IncreaseSerum CK-MB on day 3
Study
ratn: not reported in source
Isoproterenol-induced myocardial injury in male rats
Comparator
CLY + Sal
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
On the 3rd day, the serum CK-MB and cTnI levels in the ISO and CLY + ISO groups were significantly increased compared with that in the control and CLY + Sal groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The current study was designed to investigate the cardioprotective effects of cerebrolysin (CLY) on the lesion severity and inflammatory factors in male rats using isoproterenol (ISO)-induced MI model.
Summary · context
Then, CLY (5 ml/kg) was injected intraperitoneally (ip) post-treatment for 7 days.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3120196702
06AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Other
In rats, serum cTnI increased in both ISO and CLY + ISO groups versus control on the 3rd day.
In plain wordsIn rats, troponin increased with isoproterenol both with and without cerebrolysin compared with control.
Peptide
Cerebrolysin
Outcome
IncreaseSerum cTnI on day 3
Study
ratn: not reported in source
Isoproterenol-induced myocardial injury in male rats
Comparator
Control
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
On the 3rd day, the serum CK-MB and cTnI levels in the ISO and CLY + ISO groups were significantly increased compared with that in the control and CLY + Sal groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The current study was designed to investigate the cardioprotective effects of cerebrolysin (CLY) on the lesion severity and inflammatory factors in male rats using isoproterenol (ISO)-induced MI model.
Summary · context
Then, CLY (5 ml/kg) was injected intraperitoneally (ip) post-treatment for 7 days.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3120196703
07AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Other
In rats, serum cTnI increased in both ISO and CLY + ISO groups versus CLY + Sal on the 3rd day.
In plain wordsIn rats, troponin increased with isoproterenol both with and without cerebrolysin compared with cerebrolysin plus saline.
Peptide
Cerebrolysin
Outcome
IncreaseSerum cTnI on day 3
Study
ratn: not reported in source
Isoproterenol-induced myocardial injury in male rats
Comparator
CLY + Sal
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
On the 3rd day, the serum CK-MB and cTnI levels in the ISO and CLY + ISO groups were significantly increased compared with that in the control and CLY + Sal groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The current study was designed to investigate the cardioprotective effects of cerebrolysin (CLY) on the lesion severity and inflammatory factors in male rats using isoproterenol (ISO)-induced MI model.
Summary · context
Then, CLY (5 ml/kg) was injected intraperitoneally (ip) post-treatment for 7 days.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-3120196704

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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