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Study · Randomized controlled trial · 2019

4 results

Oxytocin moderates risky decision-making during the Iowa Gambling Task: A new insight based on the role of oxytocin receptor gene polymorphisms and interventional cognitive study.

Bozorgmehr A, Alizadeh F, Sadeghi B, Shahbazi A, Norouzi Ofogh S, Joghataei MT, Razian S, Heydari F, Ghadirivasfi M

Neuroscience letters11 Jun 2019Cited by 15 (Europe PMC)

PMID31200092 (opens in a new tab)DOI10.1016/j.neulet.2019.134328 (opens in a new tab)PepBankPUB-31200092
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In young healthy males, intranasal oxytocin increased the raw score on the Iowa Gambling Task compared with placebo.

    In plain wordsIn young healthy men, oxytocin nasal spray raised the raw score on a gambling decision task compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseIowa Gambling Task raw score
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin group and participants with the TT genotype demonstrated a significantly increased raw score, net score and advantageous choices, whereas the total time was not influenced remarkably.
    1 context sentence
    Summary · context
    Young healthy males received intranasal oxytocin or placebo, and the IGT was performed where raw scores, net scores and total time were recorded, and ratio of advantageous to disadvantageous choices was calculated.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In young healthy males, intranasal oxytocin increased the net score on the Iowa Gambling Task compared with placebo.

    In plain wordsIn young healthy men, oxytocin nasal spray raised the net score on a gambling decision task compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseIowa Gambling Task net score
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin group and participants with the TT genotype demonstrated a significantly increased raw score, net score and advantageous choices, whereas the total time was not influenced remarkably.
    1 context sentence
    Summary · context
    Young healthy males received intranasal oxytocin or placebo, and the IGT was performed where raw scores, net scores and total time were recorded, and ratio of advantageous to disadvantageous choices was calculated.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In young healthy males, intranasal oxytocin increased advantageous choices on the Iowa Gambling Task compared with placebo, which the authors read as reduced risk taking.

    In plain wordsIn young healthy men, oxytocin nasal spray increased safer choices in a gambling task compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseAdvantageous choices in the Iowa Gambling Task
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin group and participants with the TT genotype demonstrated a significantly increased raw score, net score and advantageous choices, whereas the total time was not influenced remarkably.
    1 context sentence
    Summary · context
    Young healthy males received intranasal oxytocin or placebo, and the IGT was performed where raw scores, net scores and total time were recorded, and ratio of advantageous to disadvantageous choices was calculated.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In young healthy males, intranasal oxytocin did not remarkably change the total time on the Iowa Gambling Task.

    In plain wordsIn young healthy men, oxytocin nasal spray did not clearly change the time taken in a gambling decision task.

    Peptide
    Oxytocin
    Outcome
    No significant changeIowa Gambling Task total time
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    Oxytocin group and participants with the TT genotype demonstrated a significantly increased raw score, net score and advantageous choices, whereas the total time was not influenced remarkably.
    1 context sentence
    Summary · context
    Young healthy males received intranasal oxytocin or placebo, and the IGT was performed where raw scores, net scores and total time were recorded, and ratio of advantageous to disadvantageous choices was calculated.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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