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Study · Not a test of the peptide alone · 2019

2 results

CD74 knockout attenuates alcohol intake-induced cardiac dysfunction through AMPK-Skp2-mediated regulation of autophagy.

Yang L, Wang S, Ma J, Li J, Yang J, Bucala R, Ren J

Biochimica et biophysica acta. Molecular basis of disease2 Jun 2019Cited by 24 (Europe PMC)

PMID31167126 (opens in a new tab)DOI10.1016/j.bbadis.2019.05.020 (opens in a new tab)PepBankPUB-31167126
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In ethanol-challenged cardiomyocytes, AICAR nullified the protection from CD74 knockout against contractile dysfunction.

    In plain wordsIn cells exposed to ethanol, AICAR removed CD74 knockout protection against heart cell dysfunction compared with no AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseCardiomyocyte dysfunction
    Study

    n: not reported in source

    Ethanol-challenged CD74 knockout cardiomyocytes
    Comparator
    CD74 knockout without AICAR
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    Moreover, the CD74 ablation-offered beneficial effects against ethanol-induced cardiomyocyte dysfunction, and GFP-Puncta formation were nullified by the AMPK activator AICAR, the Skp2 inhibitor C1 or the Sirt1 activator SRT1720 (p < 0.0001).
    1 context sentence
    Summary · context
    In vitro studies demonstrated that short-term ethanol challenge compromised cardiomyocyte contractile function and facilitated GFP-Puncta formation, which were mitigated by CD74 knockout (p < 0.0001).

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 02LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In ethanol-challenged cardiomyocytes, AICAR nullified the protection from CD74 knockout against GFP-Puncta formation.

    In plain wordsIn cells exposed to ethanol, AICAR removed CD74 knockout protection against GFP-Puncta formation compared with no AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseGFP-Puncta formation
    Study

    n: not reported in source

    Ethanol-challenged CD74 knockout cardiomyocytes
    Comparator
    CD74 knockout without AICAR
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    Moreover, the CD74 ablation-offered beneficial effects against ethanol-induced cardiomyocyte dysfunction, and GFP-Puncta formation were nullified by the AMPK activator AICAR, the Skp2 inhibitor C1 or the Sirt1 activator SRT1720 (p < 0.0001).
    1 context sentence
    Summary · context
    In vitro studies demonstrated that short-term ethanol challenge compromised cardiomyocyte contractile function and facilitated GFP-Puncta formation, which were mitigated by CD74 knockout (p < 0.0001).

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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