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Study · Not a test of the peptide alone · 2019

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Social Cognition Deficits as a Target of Early Intervention for Psychoses: A Systematic Review.

Yamada Y, Inagawa T, Sueyoshi K, Sugawara N, Ueda N, Omachi Y, Hirabayashi N, Matsumoto M, Sumiyoshi T

Frontiers in psychiatry15 May 2019Cited by 24 (Europe PMC)

PMID31156479 (opens in a new tab)PMCIDPMC6529574 (opens in a new tab)DOI10.3389/fpsyt.2019.00333 (opens in a new tab)PepBankPUB-31156479
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Summary

Backgrounds: Social cognition deficits are a core feature of schizophrenia and deteriorate functionality of patients. However, evidence is sparse for the treatment effect on social cognition impairments in the early stage of psychosis. Here, we provide a systematic review of the literature on social cognitive impairment in early psychosis in relation to its intervention. Methods: A literature search was conducted on English articles identified by Web of Science and PubMed databases, according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Results: Five papers met the inclusion criteria. Results from two studies of cognitive training and one study of modafinil indicate positive results regarding social cognition outcomes in patients with early psychosis. On the other hand, two studies with oxytocin and modafinil did not suggest such effects. Conclusions: Further research is warranted to explore the benefit of early intervention into disturbances of social cognition in psychoses.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01HumanNot a test of Oxytocin aloneSystematic reviewEfficacy outcome

    In a systematic review of early psychosis, two studies with oxytocin and modafinil did not suggest effects on social cognition.

    In plain wordsIn a review of early psychosis, two studies of oxytocin and modafinil together did not suggest benefit for social cognition.

    Peptide
    Oxytocin
    Outcome
    No significant changeSocial cognition in early psychosis
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Mental health and mood

    Source sentences

    Summary
    On the other hand, two studies with oxytocin and modafinil did not suggest such effects.
    1 context sentence
    Summary · context
    Five papers met the inclusion criteria.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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