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Study · Randomized controlled trial · 2019

2 results

Null results of oxytocin and vasopressin administration across a range of social cognitive and behavioral paradigms: Evidence from a randomized controlled trial.

Tabak BA, Teed AR, Castle E, Dutcher JM, Meyer ML, Bryan R, Irwin MR, Lieberman MD, Eisenberger NI

Psychoneuroendocrinology29 Apr 2019Cited by 36 (Europe PMC)

PMID31128568 (opens in a new tab)PMCIDPMC6687062 (opens in a new tab)DOI10.1016/j.psyneuen.2019.04.019 (opens in a new tab)PepBankPUB-31128568
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In a randomized, double-blind, placebo-controlled trial, intranasal oxytocin had no main effects on a range of social outcomes.

    In plain wordsIn a placebo-controlled trial, oxytocin had no main effects on a range of social tasks.

    Peptide
    Oxytocin
    Outcome
    No significant changeSocial cognitive and behavioral task outcomes (main effects)
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    We present a series of behavioral tasks that were conducted using a randomized, double-blind, placebo controlled, between-subjects design, in which our research group found no main effects of oxytocin and vasopressin on a host of social outcomes.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 02HumanNot a test of Oxytocin aloneRandomized controlled trialOther

    In equivalence and Bayesian analyses of the oxytocin and vasopressin trial results, 47-83% of results had enough sensitivity to detect the absence of a main effect.

    In plain wordsIn equivalence and Bayesian tests, 47-83% of the trial's results had enough sensitivity to show an absence of effect.

    Peptide
    Oxytocin
    Outcome
    Not applicableSensitivity of null results to detect absence of a main effect
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood

    Measurements

    results with sufficient sensitivity
    47 to 83%
    depending on post-hoc method

    Source sentences

    Summary
    These analyses indicated that 47-83% of our results (depending on the method of post-hoc analysis) had enough sensitivity to detect the absence of a main effect.
    1 context sentence
    Summary · context
    We present a series of behavioral tasks that were conducted using a randomized, double-blind, placebo controlled, between-subjects design, in which our research group found no main effects of oxytocin and vasopressin on a host of social outcomes.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedEarly phase 1NCT01680718

Neuropeptides and Social Behavior

University of California, Los Angelesn = 160Oct 2012 to Sept 2013

Social Psychology

Trial pageClinicalTrials.govUpdated 28 May 2015

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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