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Study · Randomized controlled trial · n = 23 · 2019

4 results

Neural and behavioral effects of oxytocin administration during theory of mind in schizophrenia and controls: a randomized control trial.

De Coster L, Lin L, Mathalon DH, Woolley JD

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology18 May 2019Cited by 24 (Europe PMC)

PMID31103018 (opens in a new tab)PMCIDPMC6785003 (opens in a new tab)DOI10.1038/s41386-019-0417-5 (opens in a new tab)PepBankPUB-31103018
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In men with schizophrenia spectrum disorder, a single dose of oxytocin significantly increased theory of mind accuracy versus placebo, but not accuracy for control stories.

    In plain wordsIn men with schizophrenia, one dose of oxytocin improved accuracy on a social-thinking task more than placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseTheory of mind accuracy in schizophrenia
    Study

    n = 23

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Oxytocin, relative to placebo, significantly increased accuracy and rTPJ activation for ToM but not control stories in schizophrenia.
    1 context sentence
    Summary · context
    In this cross-over, double-blind, and placebo-controlled functional magnetic resonance imaging study, a single dose of 40 IU of oxytocin was administered via nasal spray to male individuals with a schizophrenia spectrum disorder (schizophrenia and schizoaffective disorder, n = 23) and healthy controls (n = 25).
  2. 02HumanRandomized controlled trialMechanism

    In men with schizophrenia spectrum disorder, oxytocin significantly increased right temporo-parietal junction activation for theory of mind stories versus placebo, but not for control stories.

    In plain wordsIn men with schizophrenia, oxytocin increased activity in a social-thinking brain area more than placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseRight temporo-parietal junction activation during theory of mind
    Study

    n = 23

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Oxytocin, relative to placebo, significantly increased accuracy and rTPJ activation for ToM but not control stories in schizophrenia.
    1 context sentence
    Summary · context
    In this cross-over, double-blind, and placebo-controlled functional magnetic resonance imaging study, a single dose of 40 IU of oxytocin was administered via nasal spray to male individuals with a schizophrenia spectrum disorder (schizophrenia and schizoaffective disorder, n = 23) and healthy controls (n = 25).
  3. 03HumanRandomized controlled trialMechanism

    In men with schizophrenia spectrum disorder, oxytocin-induced increases in rTPJ activity correlated positively with accuracy.

    In plain wordsIn men with schizophrenia, larger oxytocin-linked rises in activity in this brain area went with better accuracy.

    Peptide
    Oxytocin
    Outcome
    Not applicableCorrelation of oxytocin-induced rTPJ activity increase with accuracy
    Study

    n = 23

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    a significant positive correlation was found between oxytocin induced increases in rTPJ activity and accuracy
    1 context sentence
    Summary · context
    In this cross-over, double-blind, and placebo-controlled functional magnetic resonance imaging study, a single dose of 40 IU of oxytocin was administered via nasal spray to male individuals with a schizophrenia spectrum disorder (schizophrenia and schizoaffective disorder, n = 23) and healthy controls (n = 25).
  4. 04HumanRandomized controlled trialMechanism

    In men with schizophrenia spectrum disorder, oxytocin significantly improved connectivity between the right temporo-parietal junction and medial prefrontal cortex versus placebo.

    In plain wordsIn men with schizophrenia, oxytocin improved connection between two brain areas more than placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseConnectivity between rTPJ and medial prefrontal cortex
    Study

    n = 23

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Oxytocin also significantly improved connectivity between rTPJ and mPFC in schizophrenia.
    1 context sentence
    Summary · context
    In this cross-over, double-blind, and placebo-controlled functional magnetic resonance imaging study, a single dose of 40 IU of oxytocin was administered via nasal spray to male individuals with a schizophrenia spectrum disorder (schizophrenia and schizoaffective disorder, n = 23) and healthy controls (n = 25).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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