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Study · Randomized controlled trial · n = 90 · 2019

3 results

Oxytocin reduces the link between neural and affective responses after social exclusion.

Petereit P, Rinn C, Stemmler G, Mueller EM

Biological psychology7 May 2019Cited by 15 (Europe PMC)

PMID31075364 (opens in a new tab)DOI10.1016/j.biopsycho.2019.05.002 (opens in a new tab)PepBankPUB-31075364
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In women, the positive correlation between self-reported rejection and late positive potential amplitude seen with placebo was absent with intranasal oxytocin.

    In plain wordsIn women, a link between feeling rejected and brain response to exclusion seen with placebo was absent with oxytocin.

    Peptide
    Oxytocin
    Outcome
    DecreaseCorrelation of rejection self-reports with late positive potential amplitude
    Study

    n = 90

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    In the placebo group a positive correlation was found between self-reports of rejection and late positive potential (LPP) amplitude when being omitted in the game. This correlation was absent in the oxytocin group.
    1 context sentence
    Summary · context
    To this end, intranasal oxytocin or placebo were administered in a double-blind trial to 90 females while neurophysiological and emotional reactions to exclusion in a Cyberball game were assessed.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women, intranasal oxytocin had no main effect on self-reports of rejection after social exclusion versus placebo.

    In plain wordsIn women, oxytocin did not change how rejected they said they felt after social exclusion, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeSelf-reports of rejection
    Study

    n = 90

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    No main effects of oxytocin on the self-reports of rejection
    1 context sentence
    Summary · context
    To this end, intranasal oxytocin or placebo were administered in a double-blind trial to 90 females while neurophysiological and emotional reactions to exclusion in a Cyberball game were assessed.
  3. 03HumanRandomized controlled trialMechanism

    In women, intranasal oxytocin had no main effect on the late positive potential in exclusion trials versus placebo.

    In plain wordsIn women, oxytocin did not change the brain's electrical response to exclusion compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeLate positive potential in exclusion trials
    Study

    n = 90

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    No main effects of oxytocin on the self-reports of rejection or the LPP in exclusion trials were found
    1 context sentence
    Summary · context
    To this end, intranasal oxytocin or placebo were administered in a double-blind trial to 90 females while neurophysiological and emotional reactions to exclusion in a Cyberball game were assessed.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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