Thymosin alpha-1; a natural peptide inhibits cellular proliferation, cell migration, the level of reactive oxygen species and promotes the activity of antioxidant enzymes in human lung epithelial adenocarcinoma cell line (A549).

Kharazmi-Khorassani J, Asoodeh A

Environmental toxicology8 May 2019Cited by 10 (Europe PMC)

PMID31067016DOI10.1002/tox.22765PepBankPUB-31067016

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In human lung adenocarcinoma A549 cells, Thα1 at 24 and 48 μg/ml showed an anti-proliferative effect after 24 h.
In plain wordsIn lab tests on human lung cancer cells, thymosin alpha‑1 slowed cell growth at 24 and 48 μg/ml after 24 hours.
Peptide
Thymosin alpha-1
Outcome
DecreaseA549 cell proliferation
Study
humann: not reported in source
A549 human lung adenocarcinoma cells
Outcome group
Tumor growth · Cancer
Studied dose
24 and 48 μg/ml · 24 hAs given in this study (human).
Source sentences
Summary
Thα1 revealed anti-proliferative effect at 24 and 48 μg/ml after 24 h.
2 context sentences(design, population, supporting numbers)
Summary · context
This research was conducted to investigate the biochemical effects of thymosin alpha-1 using human lung cancer cells (A549).
Summary · context
The A549 cells were treated with different concentrations of Thα1 for 24 h and the growth, inhibition of cells was determined.
Report a problemFND-3106701601
02LabIn vitro (cells)Mechanism
In A549 cells, Thα1 significantly increased catalase activity at 12 μg/ml.
In plain wordsIn lab tests on human lung cancer cells, thymosin alpha‑1 raised the activity of the antioxidant enzyme catalase.
Peptide
Thymosin alpha-1
Outcome
IncreaseCatalase activity
Study
humann: not reported in source
A549 human lung adenocarcinoma cells
Outcome group
Oxidative stress · Cancer
Studied dose
12 μg/mlAs given in this study (human).
Source sentences
Summary
Furthermore, it indicated antioxidant properties by significantly enhancing the activity of catalase (12 μg/ml), superoxide dismutase (6 and 12 μg/ml), and glutathione peroxidase (3, 6 and 12 μg/ml) and reducing the production of cellular ROS.
2 context sentences(design, population, supporting numbers)
Summary · context
This research was conducted to investigate the biochemical effects of thymosin alpha-1 using human lung cancer cells (A549).
Summary · context
The A549 cells were treated with different concentrations of Thα1 for 24 h and the growth, inhibition of cells was determined.
Report a problemFND-3106701602
03LabIn vitro (cells)Mechanism
In A549 cells, Thα1 significantly increased superoxide dismutase activity at 6 and 12 μg/ml.
In plain wordsIn lab tests on human lung cancer cells, thymosin alpha‑1 raised the activity of the antioxidant enzyme superoxide dismutase.
Peptide
Thymosin alpha-1
Outcome
IncreaseSuperoxide dismutase activity
Study
humann: not reported in source
A549 human lung adenocarcinoma cells
Outcome group
Oxidative stress · Cancer
Studied dose
6 and 12 μg/mlAs given in this study (human).
Source sentences
Summary
Furthermore, it indicated antioxidant properties by significantly enhancing the activity of catalase (12 μg/ml), superoxide dismutase (6 and 12 μg/ml), and glutathione peroxidase (3, 6 and 12 μg/ml) and reducing the production of cellular ROS.
2 context sentences(design, population, supporting numbers)
Summary · context
This research was conducted to investigate the biochemical effects of thymosin alpha-1 using human lung cancer cells (A549).
Summary · context
The A549 cells were treated with different concentrations of Thα1 for 24 h and the growth, inhibition of cells was determined.
Report a problemFND-3106701603
04LabIn vitro (cells)Mechanism
In A549 cells, Thα1 significantly increased glutathione peroxidase activity at 3, 6 and 12 μg/ml.
In plain wordsIn lab tests on human lung cancer cells, thymosin alpha‑1 raised the activity of the antioxidant enzyme glutathione peroxidase.
Peptide
Thymosin alpha-1
Outcome
IncreaseGlutathione peroxidase activity
Study
humann: not reported in source
A549 human lung adenocarcinoma cells
Outcome group
Oxidative stress · Cancer
Studied dose
3, 6 and 12 μg/mlAs given in this study (human).
Source sentences
Summary
Furthermore, it indicated antioxidant properties by significantly enhancing the activity of catalase (12 μg/ml), superoxide dismutase (6 and 12 μg/ml), and glutathione peroxidase (3, 6 and 12 μg/ml) and reducing the production of cellular ROS.
2 context sentences(design, population, supporting numbers)
Summary · context
This research was conducted to investigate the biochemical effects of thymosin alpha-1 using human lung cancer cells (A549).
Summary · context
The A549 cells were treated with different concentrations of Thα1 for 24 h and the growth, inhibition of cells was determined.
Report a problemFND-3106701604
05LabIn vitro (cells)Mechanism
In A549 cells, Thα1 reduced the production of cellular reactive oxygen species.
In plain wordsIn lab tests on human lung cancer cells, thymosin alpha‑1 lowered the production of reactive oxygen species.
Peptide
Thymosin alpha-1
Outcome
DecreaseCellular ROS production
Study
humann: not reported in source
A549 human lung adenocarcinoma cells
Outcome group
Oxidative stress · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, it indicated antioxidant properties by significantly enhancing the activity of catalase (12 μg/ml), superoxide dismutase (6 and 12 μg/ml), and glutathione peroxidase (3, 6 and 12 μg/ml) and reducing the production of cellular ROS.
2 context sentences(design, population, supporting numbers)
Summary · context
This research was conducted to investigate the biochemical effects of thymosin alpha-1 using human lung cancer cells (A549).
Summary · context
The A549 cells were treated with different concentrations of Thα1 for 24 h and the growth, inhibition of cells was determined.
Report a problemFND-3106701605
06LabIn vitro (cells)Efficacy outcome
In A549 cells, Thα1 inhibited cell migration in a concentration-dependent manner after 24 and 48 h.
In plain wordsIn lab tests on human lung cancer cells, thymosin alpha‑1 reduced cell movement, more so at higher concentrations.
Peptide
Thymosin alpha-1
Outcome
DecreaseA549 cell migration
Study
humann: not reported in source
A549 human lung adenocarcinoma cells
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated · 24 and 48 hAs given in this study (human).
Source sentences
Summary
Our results showed that Thα1 inhibits the migration of A549 cells in a concentration-dependent manner after 24 and 48 h.
2 context sentences(design, population, supporting numbers)
Summary · context
This research was conducted to investigate the biochemical effects of thymosin alpha-1 using human lung cancer cells (A549).
Summary · context
The A549 cells were treated with different concentrations of Thα1 for 24 h and the growth, inhibition of cells was determined.
Report a problemFND-3106701606
07LabIn vitro (cells)Efficacy outcome
In A549 cells, Thα1 had no significant effect on the induction of apoptosis.
In plain wordsIn lab tests on human lung cancer cells, thymosin alpha‑1 did not significantly trigger programmed cell death.
Peptide
Thymosin alpha-1
Outcome
No significant changeApoptosis induction
Study
humann: not reported in source
A549 human lung adenocarcinoma cells
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Results demonstrated no significant effect on the induction of apoptosis in A549 cells.
3 context sentences(design, population, supporting numbers)
Summary · context
Moreover, the effect of Thα1 on apoptosis was investigated by Hoechst 33342 staining and cell cycle analysis.
Summary · context
This research was conducted to investigate the biochemical effects of thymosin alpha-1 using human lung cancer cells (A549).
Summary · context
The A549 cells were treated with different concentrations of Thα1 for 24 h and the growth, inhibition of cells was determined.
Report a problemFND-3106701607

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC

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