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Study · Measured the body's own peptide · 2019

10 results

Lipids and insulin regulate mitochondrial-derived peptide (MOTS-c) in PCOS and healthy subjects.

Ramanjaneya M, Jerobin J, Bettahi I, Bensila M, Aye M, Siveen KS, Sathyapalan T, Skarulis M, Abou-Samra AB, Atkin SL

Clinical endocrinology15 May 2019Cited by 31 (Europe PMC)

PMID31066084 (opens in a new tab)DOI10.1111/cen.14007 (opens in a new tab)PepBankPUB-31066084
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

No result from this study comes from a test of the peptide.

Natural levels measured10

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelNon-randomized trialOther

    In healthy controls, intralipid infusion increased the body's own plasma MOTS‑c to 232% of basal.

    In plain wordsIn healthy adults, a fat infusion raised the body's own MOTS‑c in blood.

    Peptide
    MOTS-c
    Outcome
    IncreasePlasma MOTS-c after intralipid in controls
    Study

    n: not reported in source

    Comparator
    Basal
    Outcome group
    Aging markers · Endocrine and hormones

    Measurements

    Plasma MOTS-c
    232 % of basal
    controls

    Source sentences

    Summary
    Intralipid elevated plasma MOTS-c to 232 ± 124% of basal in control (P < 0.01) and to 349 ± 206% of basal in PCOS (P < 0.001) subjects.
    1 context sentence
    Summary · context
    All subjects underwent 5-hour intralipid/saline infusion with a hyperinsulinemic-euglycaemic clamp in the final 2 hours.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelNon-randomized trialOther

    In women with PCOS, intralipid infusion increased the body's own plasma MOTS‑c to 349% of basal.

    In plain wordsIn women with PCOS, a fat infusion raised the body's own MOTS‑c in blood.

    Peptide
    MOTS-c
    Outcome
    IncreasePlasma MOTS-c after intralipid in PCOS
    Study

    n: not reported in source

    Comparator
    Basal
    Outcome group
    Aging markers · Endocrine and hormones

    Measurements

    Plasma MOTS-c
    349 % of basal
    PCOS

    Source sentences

    Summary
    Intralipid elevated plasma MOTS-c to 232 ± 124% of basal in control (P < 0.01) and to 349 ± 206% of basal in PCOS (P < 0.001) subjects.
    1 context sentence
    Summary · context
    All subjects underwent 5-hour intralipid/saline infusion with a hyperinsulinemic-euglycaemic clamp in the final 2 hours.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelNon-randomized trialOther

    In healthy controls, insulin infusion lowered intralipid-induced plasma MOTS‑c from 232% to 165% of basal, which was not significant.

    In plain wordsIn healthy adults, insulin did not significantly lower the body's own MOTS‑c that a fat infusion had raised.

    Peptide
    MOTS-c
    Outcome
    No significant changeInsulin effect on intralipid-induced MOTS-c in controls
    Study

    n: not reported in source

    Comparator
    Intralipid alone
    Outcome group
    Aging markers · Endocrine and hormones

    Measurements

    Plasma MOTS-c
    165 % of basal
    controls with insulin

    Source sentences

    Summary
    Administration of insulin suppressed intralipid-induced MOTS-c from 232 ± 124% to 165 ± 97% (NS) in control and from 349 ± 206% to 183 ± 177% (P < 0.05) in PCOS subjects, respectively.
    1 context sentence
    Summary · context
    All subjects underwent 5-hour intralipid/saline infusion with a hyperinsulinemic-euglycaemic clamp in the final 2 hours.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelNon-randomized trialOther

    In women with PCOS, insulin infusion suppressed intralipid-induced plasma MOTS‑c from 349% to 183% of basal.

    In plain wordsIn women with PCOS, insulin lowered the body's own MOTS‑c that a fat infusion had raised.

    Peptide
    MOTS-c
    Outcome
    DecreaseInsulin effect on intralipid-induced MOTS-c in PCOS
    Study

    n: not reported in source

    Comparator
    Intralipid alone
    Outcome group
    Aging markers · Endocrine and hormones

    Measurements

    Plasma MOTS-c
    183 % of basal
    PCOS with insulin

    Source sentences

    Summary
    Administration of insulin suppressed intralipid-induced MOTS-c from 232 ± 124% to 165 ± 97% (NS) in control and from 349 ± 206% to 183 ± 177% (P < 0.05) in PCOS subjects, respectively.
    1 context sentence
    Summary · context
    All subjects underwent 5-hour intralipid/saline infusion with a hyperinsulinemic-euglycaemic clamp in the final 2 hours.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelNon-randomized trialOther

    After eight weeks of exercise, intralipid raised the body's own plasma MOTS‑c to 305% of basal in healthy controls.

    In plain wordsAfter exercise training, a fat infusion still raised the body's own MOTS‑c in healthy adults.

    Peptide
    MOTS-c
    Outcome
    IncreasePlasma MOTS-c after intralipid following exercise in controls
    Study

    n: not reported in source

    Comparator
    Basal
    Outcome group
    Aging markers · Endocrine and hormones

    Measurements

    Plasma MOTS-c
    305 % of basal
    controls after exercise

    Source sentences

    Summary
    Following exercise, intralipid elevated plasma MOTS-c to 305 ± 153% of basal in control (P < 0.01) and to 215 ± 103% of basal in PCOS (P < 0.01) subjects; insulin suppressed intralipid-induced MOTS-c only in controls.
    2 context sentences
    Summary · context
    All subjects underwent 5-hour intralipid/saline infusion with a hyperinsulinemic-euglycaemic clamp in the final 2 hours.
    Summary · context
    Subsequently, this was repeated following an eight-week exercise intervention.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  6. 06HumanEndogenous levelNon-randomized trialOther

    After eight weeks of exercise, intralipid raised the body's own plasma MOTS‑c to 215% of basal in women with PCOS.

    In plain wordsAfter exercise training, a fat infusion still raised the body's own MOTS‑c in women with PCOS.

    Peptide
    MOTS-c
    Outcome
    IncreasePlasma MOTS-c after intralipid following exercise in PCOS
    Study

    n: not reported in source

    Comparator
    Basal
    Outcome group
    Aging markers · Endocrine and hormones

    Measurements

    Plasma MOTS-c
    215 % of basal
    PCOS after exercise

    Source sentences

    Summary
    Following exercise, intralipid elevated plasma MOTS-c to 305 ± 153% of basal in control (P < 0.01) and to 215 ± 103% of basal in PCOS (P < 0.01) subjects; insulin suppressed intralipid-induced MOTS-c only in controls.
    2 context sentences
    Summary · context
    All subjects underwent 5-hour intralipid/saline infusion with a hyperinsulinemic-euglycaemic clamp in the final 2 hours.
    Summary · context
    Subsequently, this was repeated following an eight-week exercise intervention.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  7. 07HumanEndogenous levelNon-randomized trialOther

    After eight weeks of exercise, insulin suppressed intralipid-induced plasma MOTS‑c in healthy controls.

    In plain wordsAfter exercise training, insulin lowered the body's own MOTS‑c that a fat infusion had raised in healthy adults.

    Peptide
    MOTS-c
    Outcome
    DecreaseInsulin effect on intralipid-induced MOTS-c after exercise in controls
    Study

    n: not reported in source

    Comparator
    Intralipid alone
    Outcome group
    Aging markers · Endocrine and hormones

    Source sentences

    Summary
    Following exercise, intralipid elevated plasma MOTS-c to 305 ± 153% of basal in control (P < 0.01) and to 215 ± 103% of basal in PCOS (P < 0.01) subjects; insulin suppressed intralipid-induced MOTS-c only in controls.
    2 context sentences
    Summary · context
    All subjects underwent 5-hour intralipid/saline infusion with a hyperinsulinemic-euglycaemic clamp in the final 2 hours.
    Summary · context
    Subsequently, this was repeated following an eight-week exercise intervention.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  8. 08HumanEndogenous levelNon-randomized trialOther

    After eight weeks of exercise, insulin did not suppress intralipid-induced plasma MOTS‑c in women with PCOS.

    In plain wordsAfter exercise training, insulin did not lower the body's own MOTS‑c in women with PCOS.

    Peptide
    MOTS-c
    Outcome
    No significant changeInsulin effect on intralipid-induced MOTS-c after exercise in PCOS
    Study

    n: not reported in source

    Comparator
    Intralipid alone
    Outcome group
    Aging markers · Endocrine and hormones

    Source sentences

    Summary
    Following exercise, intralipid elevated plasma MOTS-c to 305 ± 153% of basal in control (P < 0.01) and to 215 ± 103% of basal in PCOS (P < 0.01) subjects; insulin suppressed intralipid-induced MOTS-c only in controls.
    2 context sentences
    Summary · context
    All subjects underwent 5-hour intralipid/saline infusion with a hyperinsulinemic-euglycaemic clamp in the final 2 hours.
    Summary · context
    Subsequently, this was repeated following an eight-week exercise intervention.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  9. 09HumanEndogenous levelNon-randomized trialOther

    Eight weeks of moderate exercise training did not change circulating MOTS‑c in healthy controls.

    In plain wordsEight weeks of exercise did not change the body's own MOTS‑c levels in healthy adults.

    Peptide
    MOTS-c
    Outcome
    No significant changeCirculating MOTS-c change after eight weeks of exercise in controls
    Study

    n: not reported in source

    Comparator
    Before exercise
    Outcome group
    Aging markers · Endocrine and hormones

    Source sentences

    Summary
    Further, eight weeks of moderate exercise training did not show any changes in circulating MOTS-c levels in healthy controls and in women with PCOS.
    1 context sentence
    Summary · context
    Subsequently, this was repeated following an eight-week exercise intervention.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

  10. 10HumanEndogenous levelNon-randomized trialOther

    Eight weeks of moderate exercise training did not change circulating MOTS‑c in women with PCOS.

    In plain wordsEight weeks of exercise did not change the body's own MOTS‑c levels in women with PCOS.

    Peptide
    MOTS-c
    Outcome
    No significant changeCirculating MOTS-c change after eight weeks of exercise in PCOS
    Study

    n: not reported in source

    Comparator
    Before exercise
    Outcome group
    Aging markers · Endocrine and hormones

    Source sentences

    Summary
    Further, eight weeks of moderate exercise training did not show any changes in circulating MOTS-c levels in healthy controls and in women with PCOS.
    1 context sentence
    Summary · context
    Subsequently, this was repeated following an eight-week exercise intervention.

    This result measures the body's own MOTS-c. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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