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Study · Not a test of the peptide alone · 2020

2 results

Maternal verbal aggression in early infancy and child's internalizing symptoms: interaction by common oxytocin polymorphisms.

Smarius LJCA, Strieder TGA, Doreleijers TAH, Vrijkotte TGM, Zafarmand MH, de Rooij SR

European archives of psychiatry and clinical neuroscience7 May 2019Cited by 7 (Europe PMC)

PMID31065789 (opens in a new tab)PMCIDPMC7332476 (opens in a new tab)DOI10.1007/s00406-019-01013-0 (opens in a new tab)PepBankPUB-31065789
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Summary

Genetic predisposition of social sensitivity might affect vulnerability to develop psychopathology after early life stress exposure. This study examined whether maternal verbally aggressive behavior in early infancy interacts with oxytocin polymorphisms in developing internalizing symptoms at ages 5-6 and 11-12. In the Amsterdam-Born-Children-and-their-Development (ABCD) study, a large observational, population-based birth cohort, maternal verbally aggressive behavior was assessed in the 13th postnatal week by a self-report questionnaire. Internalizing symptoms at age 5-6 were assessed by maternal report (N = 969) and internalizing symptoms at age 11-12 were assessed by self-report (N = 750). Data on oxytocin receptor polymorphisms rs53576 and rs2268498 and oxytocin polymorphisms rs2740210 and rs4813627 were collected. If the child was carrier of rs2740210 CA/AA polymorphism, exposure to maternal verbally aggressive behavior (10.6%) was positively associated with general anxiety at age 5-6 and emotional symptoms at age 11-12 (p for interaction = 0.011 and p = 0.015, respectively). If the child was carrier of rs4813627 GG (wild type), exposure to maternal verbally aggressive behavior was negatively associated with anxiety sensitivity and emotional symptoms at age 11-12 (p for interaction = 0.011 and p = 0.022, respectively). After exposure to maternal verbally aggressive behavior in early infancy, oxytocin polymorphisms may partly determine a child's vulnerability to internalizing symptoms.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01HumanNot a test of Oxytocin aloneObservational studyOther

    In children who carried the oxytocin gene rs2740210 CA/AA polymorphism, maternal verbal aggression was positively associated with general anxiety at age 5-6 and emotional symptoms at age 11-12.

    In plain wordsIn children with this variant of the body's own oxytocin gene, harsh maternal words in infancy were linked to more anxiety and emotional symptoms later.

    Peptide
    Oxytocin
    Outcome
    IncreaseAnxiety at age 5-6 and emotional symptoms at age 11-12 by oxytocin rs2740210 genotype
    Study

    n: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    If the child was carrier of rs2740210 CA/AA polymorphism, exposure to maternal verbally aggressive behavior (10.6%) was positively associated with general anxiety at age 5-6 and emotional symptoms at age 11-12 (p for interaction = 0.011 and p = 0.015, respectively).
    1 context sentence
    Summary · context
    This study examined whether maternal verbally aggressive behavior in early infancy interacts with oxytocin polymorphisms in developing internalizing symptoms at ages 5-6 and 11-12.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02HumanNot a test of Oxytocin aloneObservational studyOther

    In children who carried the oxytocin gene rs4813627 GG genotype, maternal verbal aggression was negatively associated with anxiety sensitivity and emotional symptoms at age 11-12.

    In plain wordsIn children with this variant of the body's own oxytocin gene, harsh maternal words were linked to less anxiety sensitivity and fewer emotional symptoms.

    Peptide
    Oxytocin
    Outcome
    DecreaseAnxiety sensitivity and emotional symptoms at age 11-12 by oxytocin rs4813627 genotype
    Study

    n: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood

    Source sentences

    Summary
    If the child was carrier of rs4813627 GG (wild type), exposure to maternal verbally aggressive behavior was negatively associated with anxiety sensitivity and emotional symptoms at age 11-12 (p for interaction = 0.011 and p = 0.022, respectively).
    1 context sentence
    Summary · context
    This study examined whether maternal verbally aggressive behavior in early infancy interacts with oxytocin polymorphisms in developing internalizing symptoms at ages 5-6 and 11-12.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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