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Study · Animal study (in vivo) · rat · 2019

7 results

Ghrelin in rat pancreatic islets decreases islet blood flow.

Drott CJ, Franzén P, Carlsson PO

American journal of physiology. Endocrinology and metabolism7 May 2019Cited by 6 (Europe PMC)

PMID31063397 (opens in a new tab)DOI10.1152/ajpendo.00004.2019 (opens in a new tab)PepBankPUB-31063397
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In fasted rats, GHRP‑6 selectively increased islet blood flow fourfold.

    In plain wordsIn fasted rats, GHRP‑6 increased blood flow in pancreatic islets fourfold.

    Peptide
    GHRP-6
    Outcome
    IncreaseIslet blood flow in fasted rats
    Study

    ratn: not reported in source

    rats
    Outcome group
    Vascular function · Metabolic and weight
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Ghrelin decreased, while GHRP-6 in fasted, but not fed, rats selectively increased islet blood flow fourfold.
    1 context sentence
    Summary · context
    Ghrelin and the GHS-R1α receptor antagonist GHRP-6 were injected intravenously in rats followed by blood flow measurements using a microsphere technique.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In fed rats, GHRP‑6 did not increase islet blood flow.

    In plain wordsIn fed rats, GHRP‑6 did not increase blood flow in pancreatic islets.

    Peptide
    GHRP-6
    Outcome
    No significant changeIslet blood flow in fed rats
    Study

    ratn: not reported in source

    rats
    Outcome group
    Vascular function · Metabolic and weight
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Ghrelin decreased, while GHRP-6 in fasted, but not fed, rats selectively increased islet blood flow fourfold.
    1 context sentence
    Summary · context
    Ghrelin and the GHS-R1α receptor antagonist GHRP-6 were injected intravenously in rats followed by blood flow measurements using a microsphere technique.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In fasted rats, GHRP‑6 improved the peak insulin response to glucose in vivo.

    In plain wordsIn fasted rats, GHRP‑6 improved the peak insulin response to glucose.

    Peptide
    GHRP-6
    Outcome
    IncreasePeak insulin response to glucose in fasted rats
    Study

    ratn: not reported in source

    rats
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    GHRP-6 in fasted rats, only, also improved the peak insulin response to glucose in vivo, thereby substantially blunting the hyperglycemia.
    1 context sentence
    Summary · context
    Ghrelin and the GHS-R1α receptor antagonist GHRP-6 were injected intravenously in rats followed by blood flow measurements using a microsphere technique.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In fed rats, GHRP‑6 did not show the improvement in peak insulin response observed only in fasted rats.

    In plain wordsIn fed rats, GHRP‑6 did not show the improved peak insulin response seen in fasted rats.

    Peptide
    GHRP-6
    Outcome
    No significant changePeak insulin response to glucose in fed rats
    Study

    ratn: not reported in source

    rats
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    GHRP-6 in fasted rats, only, also improved the peak insulin response to glucose in vivo, thereby substantially blunting the hyperglycemia.
    1 context sentence
    Summary · context
    Ghrelin and the GHS-R1α receptor antagonist GHRP-6 were injected intravenously in rats followed by blood flow measurements using a microsphere technique.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In fasted rats, GHRP‑6 substantially blunted hyperglycemia during the glucose response.

    In plain wordsIn fasted rats, GHRP‑6 reduced the rise in blood glucose.

    Peptide
    GHRP-6
    Outcome
    DecreaseHyperglycemia in fasted rats
    Study

    ratn: not reported in source

    rats
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · intravenousAs given in this study (rat).

    Source sentences

    Summary
    GHRP-6 in fasted rats, only, also improved the peak insulin response to glucose in vivo, thereby substantially blunting the hyperglycemia.
    1 context sentence
    Summary · context
    Ghrelin and the GHS-R1α receptor antagonist GHRP-6 were injected intravenously in rats followed by blood flow measurements using a microsphere technique.
  6. 06LabEx vivo tissueEfficacy outcome

    In isolated islets from fed rats, GHRP‑6 doubled glucose-stimulated insulin release.

    In plain wordsIn lab tests on islets from fed rats, GHRP‑6 doubled insulin release after glucose stimulation.

    Peptide
    GHRP-6
    Outcome
    IncreaseGlucose-stimulated insulin release from fed-rat islets
    Study

    ratn: not reported in source

    pancreatic islets from fed rats
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHRP-6 doubled glucose-stimulated insulin release in vitro of both islets obtained from fed and fasted rats.
  7. 07LabEx vivo tissueEfficacy outcome

    In isolated islets from fasted rats, GHRP‑6 doubled glucose-stimulated insulin release.

    In plain wordsIn lab tests on islets from fasted rats, GHRP‑6 doubled insulin release after glucose stimulation.

    Peptide
    GHRP-6
    Outcome
    IncreaseGlucose-stimulated insulin release from fasted-rat islets
    Study

    ratn: not reported in source

    pancreatic islets from fasted rats
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHRP-6 doubled glucose-stimulated insulin release in vitro of both islets obtained from fed and fasted rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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