Abaloparatide improves cortical geometry and trabecular microarchitecture and increases vertebral and femoral neck strength in a rat model of male osteoporosis.

Besschetnova T, Brooks DJ, Hu D, Nagano K, Nustad J, Ominsky M, Mitlak B, Hattersley G, Bouxsein ML, Baron R, Lanske B

Bone30 Apr 2019Cited by 19 (Europe PMC)

PMID31051317DOI10.1016/j.bone.2019.04.025PepBankPUB-31051317

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, both abaloparatide groups had higher vertebral trabecular bone formation rates than vehicle.
In plain wordsIn rats with removed testes, both abaloparatide groups formed more vertebral trabecular bone than vehicle.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseVertebral trabecular bone formation rate
Study
ratn = 30
Orchiectomized Sprague-Dawley rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
5 or 25 μg/kg · subcutaneous · 8 weeksAs given in this study (rat).
Source sentences
Summary
Vertebral trabecular BFR was also higher in both abaloparatide groups vs Veh, and the ABL25 group had higher trabecular osteoblast surface without increased osteoclast surface.
3 context sentences(design, population, supporting numbers)
Summary · context
This study examined the effects of abaloparatide on bone formation, bone mass, and bone strength in androgen-deficient orchiectomized (ORX) rats, a male osteoporosis model.
Summary · context
Four-month-old Sprague-Dawley rats underwent ORX or sham surgery.
Summary · context
Eight weeks later, sham-operated rats received vehicle (saline; n = 10) while ORX rats (n = 10/group) received vehicle (Veh) or abaloparatide at 5 or 25 μg/kg (ABL5 or ABL25) by daily s.c. injection for 8 weeks, followed by sacrifice.
Report a problemFND-3105131705
02AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, both abaloparatide groups improved vertebral and distal femoral trabecular bone volume compared with vehicle.
In plain wordsIn rats with removed testes, both abaloparatide groups increased vertebral and distal femoral trabecular bone volume compared with vehicle.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseTrabecular bone volume
Study
ratn = 30
Orchiectomized Sprague-Dawley rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
5 or 25 μg/kg · subcutaneous · 8 weeksAs given in this study (rat).
Source sentences
Summary
By micro-CT, the vertebra and distal femur of both abaloparatide-groups had improved trabecular bone volume and micro-architecture, and the femur diaphysis of the ABL25 group had greater cortical thickness with no increase in porosity vs Veh.
3 context sentences(design, population, supporting numbers)
Summary · context
This study examined the effects of abaloparatide on bone formation, bone mass, and bone strength in androgen-deficient orchiectomized (ORX) rats, a male osteoporosis model.
Summary · context
Four-month-old Sprague-Dawley rats underwent ORX or sham surgery.
Summary · context
Eight weeks later, sham-operated rats received vehicle (saline; n = 10) while ORX rats (n = 10/group) received vehicle (Veh) or abaloparatide at 5 or 25 μg/kg (ABL5 or ABL25) by daily s.c. injection for 8 weeks, followed by sacrifice.
Report a problemFND-3105131708
03AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, both abaloparatide groups improved vertebral and distal femoral trabecular microarchitecture compared with vehicle.
In plain wordsIn rats with removed testes, both abaloparatide groups improved vertebral and distal femoral bone structure compared with vehicle.
Peptide
Abaloparatide (Tymlos)
Outcome
Not applicableTrabecular microarchitecture
Study
ratn = 30
Orchiectomized Sprague-Dawley rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
5 or 25 μg/kg · subcutaneous · 8 weeksAs given in this study (rat).
Source sentences
Summary
By micro-CT, the vertebra and distal femur of both abaloparatide-groups had improved trabecular bone volume and micro-architecture, and the femur diaphysis of the ABL25 group had greater cortical thickness with no increase in porosity vs Veh.
3 context sentences(design, population, supporting numbers)
Summary · context
This study examined the effects of abaloparatide on bone formation, bone mass, and bone strength in androgen-deficient orchiectomized (ORX) rats, a male osteoporosis model.
Summary · context
Four-month-old Sprague-Dawley rats underwent ORX or sham surgery.
Summary · context
Eight weeks later, sham-operated rats received vehicle (saline; n = 10) while ORX rats (n = 10/group) received vehicle (Veh) or abaloparatide at 5 or 25 μg/kg (ABL5 or ABL25) by daily s.c. injection for 8 weeks, followed by sacrifice.
Report a problemFND-3105131709
04AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, both abaloparatide groups had stronger vertebrae than vehicle controls.
In plain wordsIn rats with removed testes, both abaloparatide groups had stronger vertebrae than vehicle controls.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseVertebral strength
Study
ratn = 30
Orchiectomized Sprague-Dawley rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
5 or 25 μg/kg · subcutaneous · 8 weeksAs given in this study (rat).
Source sentences
Summary
Biomechanical testing indicated that both abaloparatide-groups had stronger vertebrae and femoral necks vs Veh controls.
3 context sentences(design, population, supporting numbers)
Summary · context
This study examined the effects of abaloparatide on bone formation, bone mass, and bone strength in androgen-deficient orchiectomized (ORX) rats, a male osteoporosis model.
Summary · context
Four-month-old Sprague-Dawley rats underwent ORX or sham surgery.
Summary · context
Eight weeks later, sham-operated rats received vehicle (saline; n = 10) while ORX rats (n = 10/group) received vehicle (Veh) or abaloparatide at 5 or 25 μg/kg (ABL5 or ABL25) by daily s.c. injection for 8 weeks, followed by sacrifice.
Report a problemFND-3105131712
05AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, both abaloparatide groups had stronger femoral necks than vehicle controls.
In plain wordsIn rats with removed testes, both abaloparatide groups had stronger femoral necks than vehicle controls.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseFemoral neck strength
Study
ratn = 30
Orchiectomized Sprague-Dawley rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
5 or 25 μg/kg · subcutaneous · 8 weeksAs given in this study (rat).
Source sentences
Summary
Biomechanical testing indicated that both abaloparatide-groups had stronger vertebrae and femoral necks vs Veh controls.
3 context sentences(design, population, supporting numbers)
Summary · context
This study examined the effects of abaloparatide on bone formation, bone mass, and bone strength in androgen-deficient orchiectomized (ORX) rats, a male osteoporosis model.
Summary · context
Four-month-old Sprague-Dawley rats underwent ORX or sham surgery.
Summary · context
Eight weeks later, sham-operated rats received vehicle (saline; n = 10) while ORX rats (n = 10/group) received vehicle (Veh) or abaloparatide at 5 or 25 μg/kg (ABL5 or ABL25) by daily s.c. injection for 8 weeks, followed by sacrifice.
Report a problemFND-3105131713
06AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, abaloparatide at 25 μg/kg increased trabecular osteoblast surface compared with vehicle.
In plain wordsIn rats with removed testes, abaloparatide at 25 μg/kg increased bone-forming cell surface compared with vehicle.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseTrabecular osteoblast surface
Study
ratn = 20
Orchiectomized Sprague-Dawley rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
25 μg/kg · subcutaneous · 8 weeksAs given in this study (rat).
Source sentences
Summary
Vertebral trabecular BFR was also higher in both abaloparatide groups vs Veh, and the ABL25 group had higher trabecular osteoblast surface without increased osteoclast surface.
3 context sentences(design, population, supporting numbers)
Summary · context
This study examined the effects of abaloparatide on bone formation, bone mass, and bone strength in androgen-deficient orchiectomized (ORX) rats, a male osteoporosis model.
Summary · context
Four-month-old Sprague-Dawley rats underwent ORX or sham surgery.
Summary · context
Eight weeks later, sham-operated rats received vehicle (saline; n = 10) while ORX rats (n = 10/group) received vehicle (Veh) or abaloparatide at 5 or 25 μg/kg (ABL5 or ABL25) by daily s.c. injection for 8 weeks, followed by sacrifice.
Report a problemFND-3105131706
07AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, abaloparatide at 25 μg/kg did not increase osteoclast surface compared with vehicle.
In plain wordsIn rats with removed testes, abaloparatide at 25 μg/kg did not increase bone-resorbing cell surface compared with vehicle.
Peptide
Abaloparatide (Tymlos)
Outcome
No significant changeOsteoclast surface
Study
ratn = 20
Orchiectomized Sprague-Dawley rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
25 μg/kg · subcutaneous · 8 weeksAs given in this study (rat).
Source sentences
Summary
Vertebral trabecular BFR was also higher in both abaloparatide groups vs Veh, and the ABL25 group had higher trabecular osteoblast surface without increased osteoclast surface.
3 context sentences(design, population, supporting numbers)
Summary · context
This study examined the effects of abaloparatide on bone formation, bone mass, and bone strength in androgen-deficient orchiectomized (ORX) rats, a male osteoporosis model.
Summary · context
Four-month-old Sprague-Dawley rats underwent ORX or sham surgery.
Summary · context
Eight weeks later, sham-operated rats received vehicle (saline; n = 10) while ORX rats (n = 10/group) received vehicle (Veh) or abaloparatide at 5 or 25 μg/kg (ABL5 or ABL25) by daily s.c. injection for 8 weeks, followed by sacrifice.
Report a problemFND-3105131707
08AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, abaloparatide at 25 μg/kg increased femoral diaphyseal cortical thickness compared with vehicle.
In plain wordsIn rats with removed testes, abaloparatide at 25 μg/kg increased femoral shaft cortical thickness compared with vehicle.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseFemoral diaphyseal cortical thickness
Study
ratn = 20
Orchiectomized Sprague-Dawley rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
25 μg/kg · subcutaneous · 8 weeksAs given in this study (rat).
Source sentences
Summary
By micro-CT, the vertebra and distal femur of both abaloparatide-groups had improved trabecular bone volume and micro-architecture, and the femur diaphysis of the ABL25 group had greater cortical thickness with no increase in porosity vs Veh.
3 context sentences(design, population, supporting numbers)
Summary · context
This study examined the effects of abaloparatide on bone formation, bone mass, and bone strength in androgen-deficient orchiectomized (ORX) rats, a male osteoporosis model.
Summary · context
Four-month-old Sprague-Dawley rats underwent ORX or sham surgery.
Summary · context
Eight weeks later, sham-operated rats received vehicle (saline; n = 10) while ORX rats (n = 10/group) received vehicle (Veh) or abaloparatide at 5 or 25 μg/kg (ABL5 or ABL25) by daily s.c. injection for 8 weeks, followed by sacrifice.
Report a problemFND-3105131710
09AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, abaloparatide at 25 μg/kg did not increase femoral cortical porosity compared with vehicle.
In plain wordsIn rats with removed testes, abaloparatide at 25 μg/kg did not increase femoral cortical porosity compared with vehicle.
Peptide
Abaloparatide (Tymlos)
Outcome
No significant changeFemoral cortical porosity
Study
ratn = 20
Orchiectomized Sprague-Dawley rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
25 μg/kg · subcutaneous · 8 weeksAs given in this study (rat).
Source sentences
Summary
By micro-CT, the vertebra and distal femur of both abaloparatide-groups had improved trabecular bone volume and micro-architecture, and the femur diaphysis of the ABL25 group had greater cortical thickness with no increase in porosity vs Veh.
3 context sentences(design, population, supporting numbers)
Summary · context
This study examined the effects of abaloparatide on bone formation, bone mass, and bone strength in androgen-deficient orchiectomized (ORX) rats, a male osteoporosis model.
Summary · context
Four-month-old Sprague-Dawley rats underwent ORX or sham surgery.
Summary · context
Eight weeks later, sham-operated rats received vehicle (saline; n = 10) while ORX rats (n = 10/group) received vehicle (Veh) or abaloparatide at 5 or 25 μg/kg (ABL5 or ABL25) by daily s.c. injection for 8 weeks, followed by sacrifice.
Report a problemFND-3105131711
10AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, one or both abaloparatide groups had higher tibial periosteal mineralizing surface than vehicle.
In plain wordsIn rats with removed testes, one or both abaloparatide groups had more tibial periosteal mineralizing surface than vehicle.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreasePeriosteal mineralizing surface
Study
ratn: not reported in source
Orchiectomized Sprague-Dawley rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
5 or 25 μg/kg · subcutaneous · 8 weeksAs given in this study (rat).
Source sentences
Summary
Dynamic bone histomorphometry indicated that the tibial diaphysis of one or both abaloparatide groups had higher periosteal mineralizing surface, intracortical bone formation rate (BFR), endocortical BFR, and cortical thickness vs Veh controls.
3 context sentences(design, population, supporting numbers)
Summary · context
This study examined the effects of abaloparatide on bone formation, bone mass, and bone strength in androgen-deficient orchiectomized (ORX) rats, a male osteoporosis model.
Summary · context
Four-month-old Sprague-Dawley rats underwent ORX or sham surgery.
Summary · context
Eight weeks later, sham-operated rats received vehicle (saline; n = 10) while ORX rats (n = 10/group) received vehicle (Veh) or abaloparatide at 5 or 25 μg/kg (ABL5 or ABL25) by daily s.c. injection for 8 weeks, followed by sacrifice.
Report a problemFND-3105131701
11AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, one or both abaloparatide groups had higher tibial intracortical bone formation rates than vehicle.
In plain wordsIn rats with removed testes, one or both abaloparatide groups formed more bone within the tibial cortex than vehicle.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseIntracortical bone formation rate
Study
ratn: not reported in source
Orchiectomized Sprague-Dawley rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
5 or 25 μg/kg · subcutaneous · 8 weeksAs given in this study (rat).
Source sentences
Summary
Dynamic bone histomorphometry indicated that the tibial diaphysis of one or both abaloparatide groups had higher periosteal mineralizing surface, intracortical bone formation rate (BFR), endocortical BFR, and cortical thickness vs Veh controls.
3 context sentences(design, population, supporting numbers)
Summary · context
This study examined the effects of abaloparatide on bone formation, bone mass, and bone strength in androgen-deficient orchiectomized (ORX) rats, a male osteoporosis model.
Summary · context
Four-month-old Sprague-Dawley rats underwent ORX or sham surgery.
Summary · context
Eight weeks later, sham-operated rats received vehicle (saline; n = 10) while ORX rats (n = 10/group) received vehicle (Veh) or abaloparatide at 5 or 25 μg/kg (ABL5 or ABL25) by daily s.c. injection for 8 weeks, followed by sacrifice.
Report a problemFND-3105131702
12AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, one or both abaloparatide groups had higher tibial endocortical bone formation rates than vehicle.
In plain wordsIn rats with removed testes, one or both abaloparatide groups formed more bone at the inner tibial cortex than vehicle.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseEndocortical bone formation rate
Study
ratn: not reported in source
Orchiectomized Sprague-Dawley rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
5 or 25 μg/kg · subcutaneous · 8 weeksAs given in this study (rat).
Source sentences
Summary
Dynamic bone histomorphometry indicated that the tibial diaphysis of one or both abaloparatide groups had higher periosteal mineralizing surface, intracortical bone formation rate (BFR), endocortical BFR, and cortical thickness vs Veh controls.
3 context sentences(design, population, supporting numbers)
Summary · context
This study examined the effects of abaloparatide on bone formation, bone mass, and bone strength in androgen-deficient orchiectomized (ORX) rats, a male osteoporosis model.
Summary · context
Four-month-old Sprague-Dawley rats underwent ORX or sham surgery.
Summary · context
Eight weeks later, sham-operated rats received vehicle (saline; n = 10) while ORX rats (n = 10/group) received vehicle (Veh) or abaloparatide at 5 or 25 μg/kg (ABL5 or ABL25) by daily s.c. injection for 8 weeks, followed by sacrifice.
Report a problemFND-3105131703
13AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, one or both abaloparatide groups had greater tibial cortical thickness than vehicle.
In plain wordsIn rats with removed testes, one or both abaloparatide groups had thicker tibial cortices than vehicle.
Peptide
Abaloparatide (Tymlos)
Outcome
IncreaseTibial cortical thickness
Study
ratn: not reported in source
Orchiectomized Sprague-Dawley rats
Comparator
Vehicle
Outcome group
Bone and joint · Musculoskeletal
Studied dose
5 or 25 μg/kg · subcutaneous · 8 weeksAs given in this study (rat).
Source sentences
Summary
Dynamic bone histomorphometry indicated that the tibial diaphysis of one or both abaloparatide groups had higher periosteal mineralizing surface, intracortical bone formation rate (BFR), endocortical BFR, and cortical thickness vs Veh controls.
3 context sentences(design, population, supporting numbers)
Summary · context
This study examined the effects of abaloparatide on bone formation, bone mass, and bone strength in androgen-deficient orchiectomized (ORX) rats, a male osteoporosis model.
Summary · context
Four-month-old Sprague-Dawley rats underwent ORX or sham surgery.
Summary · context
Eight weeks later, sham-operated rats received vehicle (saline; n = 10) while ORX rats (n = 10/group) received vehicle (Veh) or abaloparatide at 5 or 25 μg/kg (ABL5 or ABL25) by daily s.c. injection for 8 weeks, followed by sacrifice.
Report a problemFND-3105131704

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Abaloparatide improves cortical geometry and trabecular microarchitecture and increases vertebral and femoral neck strength in a rat model of male osteoporosis.

Summary

Results from this study13

Version history

Subjects

Publication types

MeSH terms

Keywords