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Study · Ex vivo tissue · 2019

6 results

LL-37 promotes neutrophil extracellular trap formation in chronic rhinosinusitis with nasal polyps.

Cao Y, Chen F, Sun Y, Hong H, Wen Y, Lai Y, Xu Z, Luo X, Chen Y, Shi J, Li H

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology29 May 2019Cited by 41 (Europe PMC)

PMID31046155 (opens in a new tab)DOI10.1111/cea.13408 (opens in a new tab)PepBankPUB-31046155
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    LL‑37 promoted neutrophil extracellular trap formation by human peripheral neutrophils in a dose-dependent manner ex vivo.

    In plain wordsIn lab tests, LL‑37 made human white blood cells (neutrophils) release more neutrophil extracellular traps, and more LL‑37 gave more traps.

    Peptide
    LL-37
    Outcome
    IncreaseNET formation induced by LL-37 in peripheral neutrophils
    Study

    humann: not reported in source

    purified peripheral neutrophils
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, LL-37 promoted peripheral neutrophils to form NETs in a dose-dependent manner ex vivo.
    1 context sentence
    Summary · context
    Purified peripheral neutrophils were stimulated with LL-37 and stained with IF to identify NETs.
  2. 02LabEx vivo tissueActivity measurement

    Peripheral neutrophils from patients with CRSwNP were more susceptible to LL‑37-mediated NET formation than neutrophils from control subjects.

    In plain wordsIn lab tests, neutrophils from donors with nasal polyps formed more traps in response to LL‑37 than neutrophils from control donors.

    Peptide
    LL-37
    Outcome
    IncreaseNET formation by LL-37 in neutrophils from CRSwNP patients versus controls
    Study

    humann: not reported in source

    purified peripheral neutrophils
    Comparator
    Neutrophils from control subjects
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, peripheral neutrophils from CRSwNP patients were more susceptible to LL-37-mediated NET formation, compared with neutrophils derived from control subjects.
    1 context sentence
    Summary · context
    Purified peripheral neutrophils were stimulated with LL-37 and stained with IF to identify NETs.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03HumanEndogenous levelObservational studyOther

    In patients with chronic rhinosinusitis with nasal polyps, LL‑37 protein and mRNA levels were upregulated in nasal polyps.

    In plain wordsIn people with nasal polyps, the body's own LL‑37 protein and gene activity were higher in the polyps.

    Peptide
    LL-37
    Outcome
    IncreaseLL-37 protein and mRNA levels in nasal polyps
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Respiratory

    Source sentences

    Summary
    LL-37 protein and mRNA levels were upregulated in nasal polyps.
    1 context sentence
    Summary · context
    Purified peripheral neutrophils were stimulated with LL-37 and stained with IF to identify NETs.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  2. 04HumanEndogenous levelObservational studyOther

    In nasal polyps, LL‑37 was found in the epithelial and subepithelial layers and was mainly expressed by neutrophils.

    In plain wordsIn nasal polyps, the body's own LL‑37 was found in the tissue layers and came mainly from neutrophils.

    Peptide
    LL-37
    Outcome
    Not applicableCellular source of LL-37 in nasal polyps
    Study

    n: not reported in source

    Outcome group
    Inflammation markers · Respiratory

    Source sentences

    Summary
    LL-37 was distributed in the epithelial and subepithelial layer and mainly expressed by neutrophils.
    1 context sentence
    Summary · context
    Purified peripheral neutrophils were stimulated with LL-37 and stained with IF to identify NETs.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  3. 05HumanEndogenous levelObservational studyOther

    Neutrophil extracellular traps released LL‑37 in vivo and ex vivo in chronic rhinosinusitis with nasal polyps.

    In plain wordsIn people with nasal polyps and in lab tests, the traps released the body's own LL‑37.

    Peptide
    LL-37
    Outcome
    Not applicableRelease of LL-37 by NETs in vivo and ex vivo
    Study

    n: not reported in source

    Outcome group
    Immune response · Respiratory

    Source sentences

    Summary
    In addition, NETs released LL-37 in vivo and ex vivo.
    1 context sentence
    Summary · context
    Purified peripheral neutrophils were stimulated with LL-37 and stained with IF to identify NETs.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking LL-37.

  1. 06LabNot a test of LL-37 aloneEx vivo tissueActivity measurement

    Dexamethasone did not inhibit NET formation induced by LL‑37 in peripheral neutrophils (LL‑37 was the stimulus).

    In plain wordsIn lab tests, the steroid dexamethasone did not stop LL‑37 from making neutrophils release traps.

    Peptide
    LL-37
    Outcome
    No significant changeEffect of dexamethasone on LL-37-induced NET formation
    Study

    humann: not reported in source

    purified peripheral neutrophils
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Interestingly, dexamethasone did not inhibit the effect of LL-37 on inducing NET formation.
    1 context sentence
    Summary · context
    Purified peripheral neutrophils were stimulated with LL-37 and stained with IF to identify NETs.

    In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:57 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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