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Study · Animal study (in vivo) · rat · 2019

4 results

Ameliorative effects of cerebrolysin against isoproterenol-induced myocardial injury in male rats.

Ardjmand A, Shahaboddin ME, Mazoochi T, Ghavipanjeh G

Life sciences24 Apr 2019Cited by 17 (Europe PMC)

PMID31028802 (opens in a new tab)DOI10.1016/j.lfs.2019.04.056 (opens in a new tab)PepBankPUB-31028802
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with isoproterenol-induced myocardial injury, cerebrolysin showed significant amelioration of oxidative damage without a specified biochemical outcome.

    In plain wordsIn rats with heart injury, cerebrolysin showed improvement against oxidative damage, without a specified biochemical outcome.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseAmelioration of oxidative injury
    Study

    ratn: not reported in source

    Isoproterenol-induced myocardial injury in male rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    5 ml/kg · intraperitoneal · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    CBL administration showed a significant ameliorative increase against the oxidative ISO-induced damage.
    2 context sentences
    Summary · context
    The present study was conducted to investigate the ameliorative and antioxidant effects of cerebrolysin (CBL) on isoproterenol-induced MI in rats.
    Summary · context
    The post-treatment involved intraperitoneally injecting 5 ml/kg of CBL for 7 days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with isoproterenol-induced myocardial injury, cerebrolysin-treated animals showed lower inflammatory cell infiltration.

    In plain wordsIn rats with heart injury, cerebrolysin-treated animals showed fewer inflammatory cells in heart tissue.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseInflammatory cell infiltration
    Study

    ratn: not reported in source

    Isoproterenol-induced myocardial injury in male rats
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    5 ml/kg · intraperitoneal · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Moreover, the histopathological findings showed lower levels of the infiltration of inflammatory cells and edema and vascular proliferation in the CBL-treated rats.
    2 context sentences
    Summary · context
    The present study was conducted to investigate the ameliorative and antioxidant effects of cerebrolysin (CBL) on isoproterenol-induced MI in rats.
    Summary · context
    The post-treatment involved intraperitoneally injecting 5 ml/kg of CBL for 7 days.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with isoproterenol-induced myocardial injury, cerebrolysin-treated animals showed lower edema levels.

    In plain wordsIn rats with heart injury, cerebrolysin-treated animals showed less tissue swelling.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseMyocardial edema
    Study

    ratn: not reported in source

    Isoproterenol-induced myocardial injury in male rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    5 ml/kg · intraperitoneal · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Moreover, the histopathological findings showed lower levels of the infiltration of inflammatory cells and edema and vascular proliferation in the CBL-treated rats.
    2 context sentences
    Summary · context
    The present study was conducted to investigate the ameliorative and antioxidant effects of cerebrolysin (CBL) on isoproterenol-induced MI in rats.
    Summary · context
    The post-treatment involved intraperitoneally injecting 5 ml/kg of CBL for 7 days.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with isoproterenol-induced myocardial injury, cerebrolysin-treated animals showed lower vascular proliferation.

    In plain wordsIn rats with heart injury, cerebrolysin-treated animals showed less vascular proliferation.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseVascular proliferation
    Study

    ratn: not reported in source

    Isoproterenol-induced myocardial injury in male rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    5 ml/kg · intraperitoneal · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Moreover, the histopathological findings showed lower levels of the infiltration of inflammatory cells and edema and vascular proliferation in the CBL-treated rats.
    2 context sentences
    Summary · context
    The present study was conducted to investigate the ameliorative and antioxidant effects of cerebrolysin (CBL) on isoproterenol-induced MI in rats.
    Summary · context
    The post-treatment involved intraperitoneally injecting 5 ml/kg of CBL for 7 days.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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