Teriparatide improves alveolar bone modelling after tooth extraction in orchiectomized rats.

de Oliveira Puttini I, Gomes-Ferreira PHDS, de Oliveira D, Hassumi JS, Gonçalves PZ, Okamoto R

Archives of oral biology16 Apr 2019Cited by 18 (Europe PMC)

PMID31022626DOI10.1016/j.archoralbio.2019.04.007PepBankPUB-31022626

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats after tooth extraction, teriparatide increased bone turnover.
In plain wordsIn rats after tooth extraction, teriparatide increased bone turnover.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone turnover
Study
ratn: not reported in source
Orchiectomized male rats after central incisor extraction
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Teriparatide increased bone turnover with a higher relative gene expression of RANKL and OPG at 14 days, and at 42 days, there was a significant decrease of RANKL and an increase of OPG, this standard can also be evaluated in the ratio of RANKL to OPG.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to evaluate bone metabolism in the alveolar repair process in orchiectomized male rats treated with teriparatide.
Summary · context
A total of 78 rats were divided into three groups: 26 oriectomized rats treated with teriparatide (ORQTRAT), 26 untreated orchiectomized rats (ORQ), and 26 rats which had undergone sham surgical procedures (SHAM), all these animals underwent extraction of the central incisor tooth.
Report a problemFND-3102262601
02AnimalAnimal study (in vivo)Mechanism
In orchiectomized rats, teriparatide increased relative RANKL gene expression at 14 days.
In plain wordsIn rats, teriparatide increased RANKL gene expression at 14 days.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseRANKL gene expression at 14 days
Study
ratn: not reported in source
Orchiectomized male rats after central incisor extraction
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Teriparatide increased bone turnover with a higher relative gene expression of RANKL and OPG at 14 days, and at 42 days, there was a significant decrease of RANKL and an increase of OPG, this standard can also be evaluated in the ratio of RANKL to OPG.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to evaluate bone metabolism in the alveolar repair process in orchiectomized male rats treated with teriparatide.
Summary · context
A total of 78 rats were divided into three groups: 26 oriectomized rats treated with teriparatide (ORQTRAT), 26 untreated orchiectomized rats (ORQ), and 26 rats which had undergone sham surgical procedures (SHAM), all these animals underwent extraction of the central incisor tooth.
Report a problemFND-3102262602
03AnimalAnimal study (in vivo)Mechanism
In orchiectomized rats, teriparatide increased relative OPG gene expression at 14 days.
In plain wordsIn rats, teriparatide increased OPG gene expression at 14 days.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseOPG gene expression at 14 days
Study
ratn: not reported in source
Orchiectomized male rats after central incisor extraction
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Teriparatide increased bone turnover with a higher relative gene expression of RANKL and OPG at 14 days, and at 42 days, there was a significant decrease of RANKL and an increase of OPG, this standard can also be evaluated in the ratio of RANKL to OPG.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to evaluate bone metabolism in the alveolar repair process in orchiectomized male rats treated with teriparatide.
Summary · context
A total of 78 rats were divided into three groups: 26 oriectomized rats treated with teriparatide (ORQTRAT), 26 untreated orchiectomized rats (ORQ), and 26 rats which had undergone sham surgical procedures (SHAM), all these animals underwent extraction of the central incisor tooth.
Report a problemFND-3102262603
04AnimalAnimal study (in vivo)Mechanism
In orchiectomized rats, teriparatide decreased RANKL gene expression at 42 days.
In plain wordsIn rats, teriparatide decreased RANKL gene expression at 42 days.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseRANKL gene expression at 42 days
Study
ratn: not reported in source
Orchiectomized male rats after central incisor extraction
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Teriparatide increased bone turnover with a higher relative gene expression of RANKL and OPG at 14 days, and at 42 days, there was a significant decrease of RANKL and an increase of OPG, this standard can also be evaluated in the ratio of RANKL to OPG.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to evaluate bone metabolism in the alveolar repair process in orchiectomized male rats treated with teriparatide.
Summary · context
A total of 78 rats were divided into three groups: 26 oriectomized rats treated with teriparatide (ORQTRAT), 26 untreated orchiectomized rats (ORQ), and 26 rats which had undergone sham surgical procedures (SHAM), all these animals underwent extraction of the central incisor tooth.
Report a problemFND-3102262604
05AnimalAnimal study (in vivo)Mechanism
In orchiectomized rats, teriparatide increased OPG gene expression at 42 days.
In plain wordsIn rats, teriparatide increased OPG gene expression at 42 days.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseOPG gene expression at 42 days
Study
ratn: not reported in source
Orchiectomized male rats after central incisor extraction
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Teriparatide increased bone turnover with a higher relative gene expression of RANKL and OPG at 14 days, and at 42 days, there was a significant decrease of RANKL and an increase of OPG, this standard can also be evaluated in the ratio of RANKL to OPG.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to evaluate bone metabolism in the alveolar repair process in orchiectomized male rats treated with teriparatide.
Summary · context
A total of 78 rats were divided into three groups: 26 oriectomized rats treated with teriparatide (ORQTRAT), 26 untreated orchiectomized rats (ORQ), and 26 rats which had undergone sham surgical procedures (SHAM), all these animals underwent extraction of the central incisor tooth.
Report a problemFND-3102262605
06AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats after tooth extraction, the teriparatide group showed greater bone area.
In plain wordsIn rats after tooth extraction, the teriparatide group showed greater bone area.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone area
Study
ratn: not reported in source
Orchiectomized male rats after central incisor extraction
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Greater values of area and bone mineral deposition were found for the ORQTRAT group (p < 0.05), along with higher bone volume values (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to evaluate bone metabolism in the alveolar repair process in orchiectomized male rats treated with teriparatide.
Summary · context
A total of 78 rats were divided into three groups: 26 oriectomized rats treated with teriparatide (ORQTRAT), 26 untreated orchiectomized rats (ORQ), and 26 rats which had undergone sham surgical procedures (SHAM), all these animals underwent extraction of the central incisor tooth.
Report a problemFND-3102262606
07AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, the teriparatide group showed greater bone mineral deposition.
In plain wordsIn rats, the teriparatide group showed greater bone mineral deposition.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone mineral deposition
Study
ratn: not reported in source
Orchiectomized male rats after central incisor extraction
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Greater values of area and bone mineral deposition were found for the ORQTRAT group (p < 0.05), along with higher bone volume values (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to evaluate bone metabolism in the alveolar repair process in orchiectomized male rats treated with teriparatide.
Summary · context
A total of 78 rats were divided into three groups: 26 oriectomized rats treated with teriparatide (ORQTRAT), 26 untreated orchiectomized rats (ORQ), and 26 rats which had undergone sham surgical procedures (SHAM), all these animals underwent extraction of the central incisor tooth.
Report a problemFND-3102262607
08AnimalAnimal study (in vivo)Efficacy outcome
In orchiectomized rats, the teriparatide group showed higher bone volume.
In plain wordsIn rats, the teriparatide group showed higher bone volume.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseBone volume
Study
ratn: not reported in source
Orchiectomized male rats after central incisor extraction
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Greater values of area and bone mineral deposition were found for the ORQTRAT group (p < 0.05), along with higher bone volume values (p < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to evaluate bone metabolism in the alveolar repair process in orchiectomized male rats treated with teriparatide.
Summary · context
A total of 78 rats were divided into three groups: 26 oriectomized rats treated with teriparatide (ORQTRAT), 26 untreated orchiectomized rats (ORQ), and 26 rats which had undergone sham surgical procedures (SHAM), all these animals underwent extraction of the central incisor tooth.
Report a problemFND-3102262608
09AnimalAnimal study (in vivo)Mechanism
In orchiectomized rats, immunolabels showed greater intensity in the RANKL and OPG relationship during teriparatide-associated remodeling.
In plain wordsIn rats, immunolabels showed greater RANKL and OPG relationship intensity during bone remodeling.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseRANKL and OPG immunolabeling relationship
Study
ratn: not reported in source
Orchiectomized male rats after central incisor extraction
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
The immunolabels revealed greater intensity in the relationship of RANKL and OPG, which led to intense remodeling aiding in the process of bone formation.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study was to evaluate bone metabolism in the alveolar repair process in orchiectomized male rats treated with teriparatide.
Summary · context
A total of 78 rats were divided into three groups: 26 oriectomized rats treated with teriparatide (ORQTRAT), 26 untreated orchiectomized rats (ORQ), and 26 rats which had undergone sham surgical procedures (SHAM), all these animals underwent extraction of the central incisor tooth.
Report a problemFND-3102262609

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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