Skip to content

Study · In vitro (cells) · 2019

2 results

Reduction of aluminum ion neurotoxicity through a small peptide application - NAP treatment of Alzheimer's disease.

Yang MH, Chen SC, Lin YF, Lee YC, Huang MY, Chen KC, Wu HY, Lin PC, Gozes I, Tyan YC

Journal of food and drug analysis12 Jan 2019Cited by 17 (Europe PMC)

PMID30987727 (opens in a new tab)PMCIDPMC9296191 (opens in a new tab)DOI10.1016/j.jfda.2018.11.009 (opens in a new tab)PepBankPUB-30987727
Read at sourcePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In aluminum-exposed SH-SY5Y neuroblastoma cells, EEA1 was down-regulated after NAP-induced neuroprotective activity.

    In plain wordsIn cells exposed to aluminum ions, EEA1 decreased after NAP treatment.

    Peptide
    Davunetide
    Outcome
    DecreaseEEA1 expression
    Study

    humann: not reported in source

    SH-SY5Y neuroblastoma cells exposed to aluminum ions
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Of these four proteins, EEA1 and PI3KR2 were down-regulated after NAP-induced neuroprotective activity in neuroblastoma cells.
    1 context sentence
    Summary · context
    The objective of this study was to identify protein biomarkers associated with aluminum ions toxicity (AD-like toxicity) in a human neuroblastoma cell model, SH-SY5Y and assess potential prevention by NAP (NAPVSIPQ).
  2. 02LabIn vitro (cells)Mechanism

    In aluminum-exposed SH-SY5Y neuroblastoma cells, PI3KR2 was down-regulated after NAP-induced neuroprotective activity.

    In plain wordsIn cells exposed to aluminum ions, PI3KR2 decreased after NAP treatment.

    Peptide
    Davunetide
    Outcome
    DecreasePI3KR2 expression
    Study

    humann: not reported in source

    SH-SY5Y neuroblastoma cells exposed to aluminum ions
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Of these four proteins, EEA1 and PI3KR2 were down-regulated after NAP-induced neuroprotective activity in neuroblastoma cells.
    1 context sentence
    Summary · context
    The objective of this study was to identify protein biomarkers associated with aluminum ions toxicity (AD-like toxicity) in a human neuroblastoma cell model, SH-SY5Y and assess potential prevention by NAP (NAPVSIPQ).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.