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Study · Animal study (in vivo) · rat · 2019

6 results

Cerebrolysin attenuates ethanol-induced spatial memory impairments through inhibition of hippocampal oxidative stress and apoptotic cell death in rats.

Vaghef L, Farajdokht F, Erfani M, Majdi A, Sadigh-Eteghad S, Karimi P, Sandoghchian Shotorbani S, Seyedi Vafaee M, Mahmoudi J

Alcohol (Fayetteville, N.Y.)11 Apr 2019Cited by 18 (Europe PMC)

PMID30981808 (opens in a new tab)DOI10.1016/j.alcohol.2019.03.005 (opens in a new tab)PepBankPUB-30981808
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In alcoholic rats, cerebrolysin normalized increased hippocampal MDA levels.

    In plain wordsIn rats exposed to ethanol, cerebrolysin normalized increased levels of a marker of oxidative damage.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseHippocampal MDA levels
    Study

    ratn: not reported in source

    Chronic ethanol administration
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1, 2.5, 5 mL/kgAs given in this study (rat).

    Source sentences

    Summary
    The results showed that CBL treatment not only normalized the increased MDA levels in the alcoholic rats and enhanced antioxidant defense, but also reduced the Bax/Bcl-2 ratio and cleaved caspase-9 and -3 in the hippocampus.
    1 context sentence
    Summary · context
    The present study investigates the potential neuroprotective effect of cerebrolysin (CBL), a combination of neurotrophic factors, on the cognitive and biochemical alterations induced by chronic ethanol administration in rats.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In alcoholic rats, cerebrolysin enhanced antioxidant defense.

    In plain wordsIn rats exposed to ethanol, cerebrolysin increased antioxidant defense.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseAntioxidant defense
    Study

    ratn: not reported in source

    Chronic ethanol administration
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1, 2.5, 5 mL/kgAs given in this study (rat).

    Source sentences

    Summary
    The results showed that CBL treatment not only normalized the increased MDA levels in the alcoholic rats and enhanced antioxidant defense, but also reduced the Bax/Bcl-2 ratio and cleaved caspase-9 and -3 in the hippocampus.
    1 context sentence
    Summary · context
    The present study investigates the potential neuroprotective effect of cerebrolysin (CBL), a combination of neurotrophic factors, on the cognitive and biochemical alterations induced by chronic ethanol administration in rats.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In alcoholic rats, cerebrolysin reduced the hippocampal Bax/Bcl-2 ratio.

    In plain wordsIn rats exposed to ethanol, cerebrolysin reduced the ratio of two proteins involved in cell death.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseHippocampal Bax/Bcl-2 ratio
    Study

    ratn: not reported in source

    Chronic ethanol administration
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1, 2.5, 5 mL/kgAs given in this study (rat).

    Source sentences

    Summary
    The results showed that CBL treatment not only normalized the increased MDA levels in the alcoholic rats and enhanced antioxidant defense, but also reduced the Bax/Bcl-2 ratio and cleaved caspase-9 and -3 in the hippocampus.
    1 context sentence
    Summary · context
    The present study investigates the potential neuroprotective effect of cerebrolysin (CBL), a combination of neurotrophic factors, on the cognitive and biochemical alterations induced by chronic ethanol administration in rats.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In alcoholic rats, cerebrolysin reduced hippocampal cleaved caspase-9.

    In plain wordsIn rats exposed to ethanol, cerebrolysin reduced cleaved caspase-9 in the hippocampus.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseHippocampal cleaved caspase-9
    Study

    ratn: not reported in source

    Chronic ethanol administration
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1, 2.5, 5 mL/kgAs given in this study (rat).

    Source sentences

    Summary
    The results showed that CBL treatment not only normalized the increased MDA levels in the alcoholic rats and enhanced antioxidant defense, but also reduced the Bax/Bcl-2 ratio and cleaved caspase-9 and -3 in the hippocampus.
    1 context sentence
    Summary · context
    The present study investigates the potential neuroprotective effect of cerebrolysin (CBL), a combination of neurotrophic factors, on the cognitive and biochemical alterations induced by chronic ethanol administration in rats.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In alcoholic rats, cerebrolysin reduced hippocampal cleaved caspase-3.

    In plain wordsIn rats exposed to ethanol, cerebrolysin reduced cleaved caspase-3 in the hippocampus.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseHippocampal cleaved caspase-3
    Study

    ratn: not reported in source

    Chronic ethanol administration
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1, 2.5, 5 mL/kgAs given in this study (rat).

    Source sentences

    Summary
    The results showed that CBL treatment not only normalized the increased MDA levels in the alcoholic rats and enhanced antioxidant defense, but also reduced the Bax/Bcl-2 ratio and cleaved caspase-9 and -3 in the hippocampus.
    1 context sentence
    Summary · context
    The present study investigates the potential neuroprotective effect of cerebrolysin (CBL), a combination of neurotrophic factors, on the cognitive and biochemical alterations induced by chronic ethanol administration in rats.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In alcoholic rats, cerebrolysin improved spatial memory performance in the Morris water maze.

    In plain wordsIn rats exposed to ethanol, cerebrolysin improved spatial memory in a maze test.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSpatial memory performance
    Study

    ratn: not reported in source

    Chronic ethanol administration
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    1, 2.5, 5 mL/kgAs given in this study (rat).

    Source sentences

    Summary
    These results were parallel with improvement in spatial memory performance in the MWM test.
    2 context sentences
    Summary · context
    The results showed that CBL treatment not only normalized the increased MDA levels in the alcoholic rats and enhanced antioxidant defense, but also reduced the Bax/Bcl-2 ratio and cleaved caspase-9 and -3 in the hippocampus.
    Summary · context
    The present study investigates the potential neuroprotective effect of cerebrolysin (CBL), a combination of neurotrophic factors, on the cognitive and biochemical alterations induced by chronic ethanol administration in rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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