Skip to content

Study · Randomized controlled trial · n = 113 · 2019

4 results

Human growth hormone for poor responders: a randomized placebo-controlled trial provides no evidence for improved live birth rate.

Norman RJ, Alvino H, Hull LM, Mol BW, Hart RJ, Kelly TL, Rombauts L

Reproductive biomedicine online27 Feb 2019Cited by 54 (Europe PMC)

PMID30954433 (opens in a new tab)DOI10.1016/j.rbmo.2019.02.003 (opens in a new tab)PepBankPUB-30954433
Source linkPubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In women with poor ovarian response, live births occurred in 9/62 (14.5%) with growth hormone versus 7/51 (13.7%) with placebo.

    In plain wordsIn women with poor ovarian response, growth hormone did not improve live birth rates versus placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeLive birth rate
    Study

    n = 113

    Comparator
    Placebo
    Analysis
    Primary
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Live births
    9 births
    growth hormone
    Participants
    62 women
    growth hormone
    Live birth rate
    14.5%
    growth hormone
    Risk difference
    0.8%
    growth hormone versus placebo
    Risk difference 95% CI
    −12.1 to 13.7%
    growth hormone versus placebo
    Odds ratio
    1.07 ratio
    growth hormone versus placebo
    Odds ratio 95% CI
    0.37 to 3.1 ratio
    growth hormone versus placebo

    Source sentences

    Summary
    The live birth rates following an IVF cycle were 9/62 (14.5%) for growth hormone and 7/51 (13.7%) for the placebo group (risk difference 0.8%, 95% confidence interval [CI] -12.1 to 13.7%; odds ratio [OR] 1.07, 95% CI 0.37-3.10).
    3 context sentences
    Summary · context
    Double-blind, placebo-controlled, randomized clinical trial comparing HGH to placebo in maximal stimulation in an IVF cycle.
    Summary · context
    Women receiving ovarian stimulation in one IVF cycle, having failed to produce more than 5 eggs in a previous cycle with more than 250 IU/day of FSH were included.
    Summary · context
    HGH or placebo were added from the start of the cycle in a double-blinded manner.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women with poor ovarian response, growth hormone increased the odds of oocyte retrieval versus placebo (OR 5.67, 95% CI 1.54-20.80).

    In plain wordsIn women with poor ovarian response, growth hormone increased the odds of egg retrieval versus placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseOocyte retrieval
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Odds ratio
    5.67 ratio
    oocyte retrieval
    Odds ratio 95% CI
    1.54 to 20.8 ratio
    oocyte retrieval

    Source sentences

    Summary
    There was a greater odds of oocyte retrieval with growth hormone (OR 5.67, 95% CI 1.54-20.80) but no better chance of embryo transfer (OR 1.42, 95% CI 0.50-4.00).
    3 context sentences
    Summary · context
    Double-blind, placebo-controlled, randomized clinical trial comparing HGH to placebo in maximal stimulation in an IVF cycle.
    Summary · context
    Women receiving ovarian stimulation in one IVF cycle, having failed to produce more than 5 eggs in a previous cycle with more than 250 IU/day of FSH were included.
    Summary · context
    HGH or placebo were added from the start of the cycle in a double-blinded manner.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In women with poor ovarian response, growth hormone did not improve the chance of embryo transfer versus placebo (OR 1.42, 95% CI 0.50-4.00).

    In plain wordsIn women with poor ovarian response, growth hormone did not improve the chance of embryo transfer versus placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeEmbryo transfer
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Odds ratio
    1.42 ratio
    embryo transfer
    Odds ratio 95% CI
    0.5 to 4 ratio
    embryo transfer

    Source sentences

    Summary
    There was a greater odds of oocyte retrieval with growth hormone (OR 5.67, 95% CI 1.54-20.80) but no better chance of embryo transfer (OR 1.42, 95% CI 0.50-4.00).
    3 context sentences
    Summary · context
    Double-blind, placebo-controlled, randomized clinical trial comparing HGH to placebo in maximal stimulation in an IVF cycle.
    Summary · context
    Women receiving ovarian stimulation in one IVF cycle, having failed to produce more than 5 eggs in a previous cycle with more than 250 IU/day of FSH were included.
    Summary · context
    HGH or placebo were added from the start of the cycle in a double-blinded manner.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In births after IVF for poor ovarian response, birth weights were comparable with growth hormone and placebo.

    In plain wordsIn births after IVF for poor ovarian response, birth weights were comparable with growth hormone and placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeBirth weight
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Birth weights were comparable.
    3 context sentences
    Summary · context
    Double-blind, placebo-controlled, randomized clinical trial comparing HGH to placebo in maximal stimulation in an IVF cycle.
    Summary · context
    Women receiving ovarian stimulation in one IVF cycle, having failed to produce more than 5 eggs in a previous cycle with more than 250 IU/day of FSH were included.
    Summary · context
    HGH or placebo were added from the start of the cycle in a double-blinded manner.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.