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Study · Measured the body's own peptide · 2019

2 results

The immediate effects of cervical spine manipulation on pain and biochemical markers in females with acute non-specific mechanical neck pain: a randomized clinical trial.

Lohman EB, Pacheco GR, Gharibvand L, Daher N, Devore K, Bains G, AlAmeri M, Berk LS

The Journal of manual & manipulative therapy11 Dec 2018Cited by 20 (Europe PMC)

PMID30935335 (opens in a new tab)PMCIDPMC7025692 (opens in a new tab)DOI10.1080/10669817.2018.1553696 (opens in a new tab)PepBankPUB-30935335
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialMechanism

    In women with acute non-specific mechanical neck pain, serum oxytocin was higher after cervical spinal manipulation than before it (154.5 vs 185.1, p = .012).

    In plain wordsIn women with neck pain, the body's own oxytocin level in blood rose right after spinal manipulation.

    Peptide
    Oxytocin
    Outcome
    IncreaseSerum oxytocin after cervical spinal manipulation
    Study

    n: not reported in source

    Comparator
    Pre-manipulation level
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    In the CSM group, there were significant increases in pre- versus post-manipulation mean oxytocin (154.5 ± 60.1 vs. 185.1 ± 75.6, p = .012
    1 context sentence
    Summary · context
    Twenty-eight female subjects with non-specific mechanical neck pain were randomly assigned to one of two interventions (CSM versus sham CSM).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelRandomized controlled trialMechanism

    In women with acute non-specific mechanical neck pain, serum oxytocin did not change significantly after sham cervical spinal manipulation (p > .05).

    In plain wordsIn women with neck pain, the body's own oxytocin level in blood did not change after sham manipulation.

    Peptide
    Oxytocin
    Outcome
    No significant changeSerum oxytocin after sham manipulation
    Study

    n: not reported in source

    Comparator
    Pre-sham level
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    In the sham group, there were no significant differences in any of the biomarkers (p > .05).
    1 context sentence
    Summary · context
    Twenty-eight female subjects with non-specific mechanical neck pain were randomly assigned to one of two interventions (CSM versus sham CSM).

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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