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Study · Animal study (in vivo) · mouse · 2019

6 results

The vasoreparative potential of endothelial colony-forming cells in the ischemic retina is enhanced by cibinetide, a non-hematopoietic erythropoietin mimetic.

O'Leary OE, Canning P, Reid E, Bertelli PM, McKeown S, Brines M, Cerami A, Du X, Xu H, Chen M, Dutton L, Brazil DP, Medina RJ, Stitt AW

Experimental eye research12 Mar 2019Cited by 16 (Europe PMC)

PMID30876881 (opens in a new tab)DOI10.1016/j.exer.2019.03.001 (opens in a new tab)PepBankPUB-30876881
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In the mouse oxygen-induced retinopathy model, preconditioning ECFCs with EPO or ARA290 before delivery did not enhance vasoreparative function.

    In plain wordsIn mice with retinal ischemia, pretreating repair cells with ARA290 or EPO before delivery did not improve their vessel repair.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    No significant changeVasoreparative function of ECFCs preconditioned with ARA290 or EPO
    Study

    mousen: not reported in source

    Oxygen-induced retinopathy (OIR) mouse model of retinal ischemia
    Outcome group
    Wound healing · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Preconditioning of ECFCs with EPO or ARA290 prior to delivery to the ischemic retina did not enhance vasoreparative function.
    1 context sentence
    Summary · context
    Efficacy of ECFC transplantation therapy to promote retinal vascular repair in the presence and absence of ARA290 was studied in the oxygen induced retinopathy (OIR) model of retinal ischemia.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In the mouse oxygen-induced retinopathy model, systemic ARA290 reduced pro-inflammatory expression of IL-1β in the retina.

    In plain wordsIn mice with retinal ischemia, ARA290 given through the body lowered an inflammatory signal in the retina.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseRetinal IL-1β expression
    Study

    mousen: not reported in source

    Oxygen-induced retinopathy (OIR) mouse model of retinal ischemia
    Outcome group
    Inflammation markers · Eye
    Studied dose
    Dose not stated · systemicAs given in this study (mouse).

    Source sentences

    Summary
    ARA290 delivered systemically to OIR mice reduced pro-inflammatory expression of IL-1β and TNF-α in the mouse retina.
    2 context sentences
    Summary · context
    Efficacy of ECFC transplantation therapy to promote retinal vascular repair in the presence and absence of ARA290 was studied in the oxygen induced retinopathy (OIR) model of retinal ischemia.
    Summary · context
    The inflammatory cytokine profile and microglial activation were studied as readouts of inflammation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In the mouse oxygen-induced retinopathy model, systemic ARA290 reduced pro-inflammatory expression of TNF-α in the retina.

    In plain wordsIn mice with retinal ischemia, ARA290 given through the body lowered an inflammatory signal in the retina.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseRetinal TNF-α expression
    Study

    mousen: not reported in source

    Oxygen-induced retinopathy (OIR) mouse model of retinal ischemia
    Outcome group
    Inflammation markers · Eye
    Studied dose
    Dose not stated · systemicAs given in this study (mouse).

    Source sentences

    Summary
    ARA290 delivered systemically to OIR mice reduced pro-inflammatory expression of IL-1β and TNF-α in the mouse retina.
    2 context sentences
    Summary · context
    Efficacy of ECFC transplantation therapy to promote retinal vascular repair in the presence and absence of ARA290 was studied in the oxygen induced retinopathy (OIR) model of retinal ischemia.
    Summary · context
    The inflammatory cytokine profile and microglial activation were studied as readouts of inflammation.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In the mouse oxygen-induced retinopathy model, the vasoreparative function of ECFCs was enhanced in the presence of ARA290 but not EPO.

    In plain wordsIn mice with retinal ischemia, repair cells repaired vessels better with ARA290 but not with EPO.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseVasoreparative function of transplanted ECFCs
    Study

    mousen: not reported in source

    Oxygen-induced retinopathy (OIR) mouse model of retinal ischemia with ECFC transplantation
    Comparator
    EPO
    Outcome group
    Wound healing · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The vasoreparative function of ECFCs was enhanced in the presence of ARA290 but not EPO.
    1 context sentence
    Summary · context
    Efficacy of ECFC transplantation therapy to promote retinal vascular repair in the presence and absence of ARA290 was studied in the oxygen induced retinopathy (OIR) model of retinal ischemia.
  5. 05LabIn vitro (cells)Mechanism

    In endothelial colony-forming cells in vitro, ARA290 activated pro-survival signaling.

    In plain wordsIn cells, ARA290 switched on survival signals in endothelial colony-forming cells.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreasePro-survival signaling in ECFCs
    Study

    n: not reported in source

    Endothelial colony-forming cells (ECFC) in vitro
    Outcome group
    Cell viability and death · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ARA290 activated pro-survival signaling
    1 context sentence
    Summary · context
    The effects of ARA290 on pro-survival signaling and function were assessed in ECFC cultures in vitro.
  6. 06LabIn vitro (cells)Efficacy outcome

    In endothelial colony-forming cells in vitro, ARA290 enhanced cell viability in response to H2O2-mediated oxidative stress.

    In plain wordsIn cells, ARA290 improved the survival of endothelial colony-forming cells under oxidative stress.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    IncreaseECFC viability under oxidative stress
    Study

    n: not reported in source

    Endothelial colony-forming cells (ECFC) in vitro under H2O2 oxidative stress
    Outcome group
    Cell viability and death · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    enhanced cell viability in response to H2O2-mediated oxidative stress in ECFCs in vitro.
    1 context sentence
    Summary · context
    The effects of ARA290 on pro-survival signaling and function were assessed in ECFC cultures in vitro.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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