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Study · Animal study (in vivo) · rat · 2019

6 results

Thymulin treatment attenuates inflammatory pain by modulating spinal cellular and molecular signaling pathways.

Nasseri B, Zaringhalam J, Daniali S, Manaheji H, Abbasnejad Z, Nazemian V

International immunopharmacology6 Mar 2019Cited by 17 (Europe PMC)

PMID30851702 (opens in a new tab)DOI10.1016/j.intimp.2019.02.042 (opens in a new tab)PepBankPUB-30851702
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with CFA-induced inflammation, thymulin notably reduced thermal hyperalgesia.

    In plain wordsIn rats with induced inflammation, thymulin reduced increased sensitivity to heat pain.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseThermal hyperalgesia
    Study

    ratn: not reported in source

    Complete Freund's adjuvant-induced inflammation
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    We demonstrated that thymulin treatment notably reduced thermal hyperalgesia and paw edema induced by CFA.
    2 context sentences
    Summary · context
    In this study, we investigated the effects of different doses and various timings of thymulin intraperitoneal administration on spinal microglial activity and intracellular pathways in an inflammatory rat model of Complete Freund's adjuvant (CFA).
    Summary · context
    Thymulin treatment was implemented following CFA-induced inflammation for 21 days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with CFA-induced inflammation, thymulin notably reduced paw edema.

    In plain wordsIn rats with induced inflammation, thymulin reduced paw swelling.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreasePaw edema
    Study

    ratn: not reported in source

    Complete Freund's adjuvant-induced inflammation
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated · intraperitoneal · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    We demonstrated that thymulin treatment notably reduced thermal hyperalgesia and paw edema induced by CFA.
    2 context sentences
    Summary · context
    In this study, we investigated the effects of different doses and various timings of thymulin intraperitoneal administration on spinal microglial activity and intracellular pathways in an inflammatory rat model of Complete Freund's adjuvant (CFA).
    Summary · context
    Thymulin treatment was implemented following CFA-induced inflammation for 21 days.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with CFA-induced inflammation, thymulin reduced microglial activation.

    In plain wordsIn rats with induced inflammation, thymulin reduced activation of spinal immune cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseSpinal microglial activation
    Study

    ratn: not reported in source

    Complete Freund's adjuvant-induced inflammation
    Outcome group
    Immune response · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, molecular investigations showed that thymulin reduced CFA-induced activation of microglia cells, phosphorylation of p38 MAPK and the production of spinal pro-inflammatory cytokines (TNF-α, IL-6) during the study.
    2 context sentences
    Summary · context
    In this study, we investigated the effects of different doses and various timings of thymulin intraperitoneal administration on spinal microglial activity and intracellular pathways in an inflammatory rat model of Complete Freund's adjuvant (CFA).
    Summary · context
    Thymulin treatment was implemented following CFA-induced inflammation for 21 days.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with CFA-induced inflammation, thymulin reduced p38 MAPK phosphorylation.

    In plain wordsIn rats with induced inflammation, thymulin reduced p38 MAPK phosphorylation.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Decreasep38 MAPK phosphorylation
    Study

    ratn: not reported in source

    Complete Freund's adjuvant-induced inflammation
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, molecular investigations showed that thymulin reduced CFA-induced activation of microglia cells, phosphorylation of p38 MAPK and the production of spinal pro-inflammatory cytokines (TNF-α, IL-6) during the study.
    2 context sentences
    Summary · context
    In this study, we investigated the effects of different doses and various timings of thymulin intraperitoneal administration on spinal microglial activity and intracellular pathways in an inflammatory rat model of Complete Freund's adjuvant (CFA).
    Summary · context
    Thymulin treatment was implemented following CFA-induced inflammation for 21 days.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with CFA-induced inflammation, thymulin reduced spinal TNF-α production.

    In plain wordsIn rats with induced inflammation, thymulin reduced spinal TNF-α production.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseSpinal TNF-α production
    Study

    ratn: not reported in source

    Complete Freund's adjuvant-induced inflammation
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, molecular investigations showed that thymulin reduced CFA-induced activation of microglia cells, phosphorylation of p38 MAPK and the production of spinal pro-inflammatory cytokines (TNF-α, IL-6) during the study.
    2 context sentences
    Summary · context
    In this study, we investigated the effects of different doses and various timings of thymulin intraperitoneal administration on spinal microglial activity and intracellular pathways in an inflammatory rat model of Complete Freund's adjuvant (CFA).
    Summary · context
    Thymulin treatment was implemented following CFA-induced inflammation for 21 days.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with CFA-induced inflammation, thymulin reduced spinal IL-6 production.

    In plain wordsIn rats with induced inflammation, thymulin reduced spinal IL-6 production.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseSpinal IL-6 production
    Study

    ratn: not reported in source

    Complete Freund's adjuvant-induced inflammation
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, molecular investigations showed that thymulin reduced CFA-induced activation of microglia cells, phosphorylation of p38 MAPK and the production of spinal pro-inflammatory cytokines (TNF-α, IL-6) during the study.
    2 context sentences
    Summary · context
    In this study, we investigated the effects of different doses and various timings of thymulin intraperitoneal administration on spinal microglial activity and intracellular pathways in an inflammatory rat model of Complete Freund's adjuvant (CFA).
    Summary · context
    Thymulin treatment was implemented following CFA-induced inflammation for 21 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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