Skip to content

Study · In vitro (cells) · 2019

6 results

Effect of short peptides on neuronal differentiation of stem cells.

Caputi S, Trubiani O, Sinjari B, Trofimova S, Diomede F, Linkova N, Diatlova A, Khavinson V

International journal of immunopathology and pharmacology1 Jan 2019Cited by 43 (Europe PMC)

PMID30791821 (opens in a new tab)PMCIDPMC6376556 (opens in a new tab)DOI10.1177/2058738419828613 (opens in a new tab)PepBankPUB-30791821
Read at sourcePubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human periodontal ligament stem cells, KED alone increased GAP43 expression.

    In plain wordsIn cells, KED alone increased GAP43 expression.

    Peptide
    Vesugen (KED)
    Outcome
    IncreaseGAP43 expression
    Study

    humann: not reported in source

    human periodontal ligament stem cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Growth-Associated Protein 43 (GAP43), which implements neurotransmission mechanisms and neuroplasticity, demonstrated an increased expression in hPDLSCs cultured with a compound of all studied peptides and with KED alone.
    1 context sentence
    Summary · context
    The effect of AED (Ala-Glu-Asp), KED (Lys-Glu-Asp), KE (Lys-Glu), AEDG (Ala-Glu-Asp-Gly) peptides and their compound on neuronal differentiation of human periodontal ligament stem cells (hPDLSCs) was studied by immunofluorescence and western blot analysis.
  2. 02LabIn vitro (cells)Mechanism

    In human periodontal ligament stem cells, KED increased Nestin expression.

    In plain wordsIn cells, KED increased Nestin expression.

    Peptide
    Vesugen (KED)
    Outcome
    IncreaseNestin expression
    Study

    humann: not reported in source

    human periodontal ligament stem cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The peptide compound and KED, increase the expression of Nestin (neurofilament protein), expressed in early neuronal precursors in hPDLSCs cultures.
    1 context sentence
    Summary · context
    The effect of AED (Ala-Glu-Asp), KED (Lys-Glu-Asp), KE (Lys-Glu), AEDG (Ala-Glu-Asp-Gly) peptides and their compound on neuronal differentiation of human periodontal ligament stem cells (hPDLSCs) was studied by immunofluorescence and western blot analysis.

Studies that did not test the peptide alone4

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 03LabNot a test of Epitalon aloneIn vitro (cells)Mechanism

    In human periodontal ligament stem cells, a compound of the peptides AEDG, KE, AED and KED increased expression of GAP43, a neuroplasticity protein.

    In plain wordsIn lab cells, a mix of four short peptides, including AEDG, raised levels of a protein linked to nerve cell function.

    Peptide
    Epitalon
    Outcome
    IncreaseGAP43 expression
    Study

    humann: not reported in source

    human periodontal ligament stem cells (hPDLSCs)
    Outcome group
    Cell proliferation and differentiation · Nervous system and cognition

    Source sentences

    Summary
    demonstrated an increased expression in hPDLSCs cultured with a compound of all studied peptides and with KED alone.
    1 context sentence
    Summary · context
    The effect of AED (Ala-Glu-Asp), KED (Lys-Glu-Asp), KE (Lys-Glu), AEDG (Ala-Glu-Asp-Gly) peptides and their compound on neuronal differentiation of human periodontal ligament stem cells (hPDLSCs) was studied by immunofluorescence and western blot analysis.

    In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.

  2. 04LabNot a test of Epitalon aloneIn vitro (cells)Mechanism

    In human periodontal ligament stem cells, the compound of the four peptides increased expression of nestin, a marker of early neuronal precursors.

    In plain wordsIn lab cells, a mix of four short peptides, including AEDG, raised a marker of early nerve precursor cells.

    Peptide
    Epitalon
    Outcome
    IncreaseNestin expression
    Study

    humann: not reported in source

    human periodontal ligament stem cells (hPDLSCs)
    Outcome group
    Cell proliferation and differentiation · Nervous system and cognition

    Source sentences

    Summary
    The peptide compound and KED, increase the expression of Nestin (neurofilament protein)
    1 context sentence
    Summary · context
    The effect of AED (Ala-Glu-Asp), KED (Lys-Glu-Asp), KE (Lys-Glu), AEDG (Ala-Glu-Asp-Gly) peptides and their compound on neuronal differentiation of human periodontal ligament stem cells (hPDLSCs) was studied by immunofluorescence and western blot analysis.

    In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.

  3. 05LabNot a test of Vesugen (KED) aloneIn vitro (cells)Mechanism

    In human periodontal ligament stem cells, the combination of AED, KED, KE and AEDG increased GAP43 expression.

    In plain wordsIn cells, the combination of AED, KED, KE and AEDG increased GAP43 expression.

    Peptide
    Vesugen (KED)
    Outcome
    IncreaseGAP43 expression with peptide combination
    Study

    humann: not reported in source

    human periodontal ligament stem cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Growth-Associated Protein 43 (GAP43), which implements neurotransmission mechanisms and neuroplasticity, demonstrated an increased expression in hPDLSCs cultured with a compound of all studied peptides and with KED alone.
    1 context sentence
    Summary · context
    The effect of AED (Ala-Glu-Asp), KED (Lys-Glu-Asp), KE (Lys-Glu), AEDG (Ala-Glu-Asp-Gly) peptides and their compound on neuronal differentiation of human periodontal ligament stem cells (hPDLSCs) was studied by immunofluorescence and western blot analysis.

    In this study, Vesugen (KED) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vesugen (KED).

  4. 06LabNot a test of Vesugen (KED) aloneIn vitro (cells)Mechanism

    In human periodontal ligament stem cells, the combination of AED, KED, KE and AEDG increased Nestin expression.

    In plain wordsIn cells, the combination of AED, KED, KE and AEDG increased Nestin expression.

    Peptide
    Vesugen (KED)
    Outcome
    IncreaseNestin expression with peptide combination
    Study

    humann: not reported in source

    human periodontal ligament stem cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    The peptide compound and KED, increase the expression of Nestin (neurofilament protein), expressed in early neuronal precursors in hPDLSCs cultures.
    1 context sentence
    Summary · context
    The effect of AED (Ala-Glu-Asp), KED (Lys-Glu-Asp), KE (Lys-Glu), AEDG (Ala-Glu-Asp-Gly) peptides and their compound on neuronal differentiation of human periodontal ligament stem cells (hPDLSCs) was studied by immunofluorescence and western blot analysis.

    In this study, Vesugen (KED) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vesugen (KED).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 10Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 7 times, first on 21 Oct 2026, 17:05 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    21 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    10 Oct 2026, 08:19 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.