Dulaglutide ameliorates STZ induced AD-like impairment of learning and memory ability by modulating hyperphosphorylation of tau and NFs through GSK3β.

Zhou M, Chen S, Peng P, Gu Z, Yu J, Zhao G, Deng Y

Biochemical and biophysical research communications14 Feb 2019Cited by 74 (Europe PMC)

PMID30773255DOI10.1016/j.bbrc.2019.01.103PepBankPUB-30773255

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In STZ-treated mice, tau hyperphosphorylation was lower in the dulaglutide group than the STZ group.
In plain wordsIn mice, tau hyperphosphorylation was lower with dulaglutide than in the STZ group.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseTau hyperphosphorylation versus STZ
Study
mousen: not reported in source
STZ-induced AD-like impairment in male C57/BL6 mice
Comparator
STZ group
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The results displayed that the hyperphosphorylation of tau and NFs were increased in the STZ and Ex groups compared to the control and Dul groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study is to explore the effects of dulaglutide on the learning and memory impairment in AD mice induced by injection of streptozocin (STZ) via intracerebroventricularly (i.c.v.).
Summary · context
32 male C57/BL6 mice were randomly divided into four groups: control group (CON); AD model group (STZ); dulaglutide treated (Dul); dulaglutide and exendin(9-39) (Ex).
Report a problemFND-3077325501
02AnimalAnimal study (in vivo)Mechanism
In STZ-treated mice, neurofilament hyperphosphorylation was lower in the dulaglutide group than the STZ group.
In plain wordsIn mice, neurofilament hyperphosphorylation was lower with dulaglutide than in the STZ group.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseNeurofilament hyperphosphorylation versus STZ
Study
mousen: not reported in source
STZ-induced AD-like impairment in male C57/BL6 mice
Comparator
STZ group
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
The results displayed that the hyperphosphorylation of tau and NFs were increased in the STZ and Ex groups compared to the control and Dul groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study is to explore the effects of dulaglutide on the learning and memory impairment in AD mice induced by injection of streptozocin (STZ) via intracerebroventricularly (i.c.v.).
Summary · context
32 male C57/BL6 mice were randomly divided into four groups: control group (CON); AD model group (STZ); dulaglutide treated (Dul); dulaglutide and exendin(9-39) (Ex).
Report a problemFND-3077325503
03AnimalAnimal study (in vivo)Efficacy outcome
In STZ-treated mice, dulaglutide significantly shortened escape latency in the Morris water maze.
In plain wordsIn mice with STZ-induced impairment, dulaglutide reduced the time to escape in a water maze.
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseEscape latency
Study
mousen: not reported in source
STZ-induced AD-like impairment in male C57/BL6 mice
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Dulaglutide also significantly shortened the escape latency and increased the number of hidden platform crossings in MWM test.
3 context sentences(design, population, supporting numbers)
Summary · context
Morris water maze (MWM) test was used to assess the spatial learning and memory ability.
Summary · context
The aim of this study is to explore the effects of dulaglutide on the learning and memory impairment in AD mice induced by injection of streptozocin (STZ) via intracerebroventricularly (i.c.v.).
Summary · context
32 male C57/BL6 mice were randomly divided into four groups: control group (CON); AD model group (STZ); dulaglutide treated (Dul); dulaglutide and exendin(9-39) (Ex).
Report a problemFND-3077325505
04AnimalAnimal study (in vivo)Efficacy outcome
In STZ-treated mice, dulaglutide increased hidden platform crossings in the Morris water maze.
In plain wordsIn mice with STZ-induced impairment, dulaglutide increased hidden platform crossings in a water maze.
Peptide
Dulaglutide (Trulicity)
Outcome
IncreaseHidden platform crossings
Study
mousen: not reported in source
STZ-induced AD-like impairment in male C57/BL6 mice
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Dulaglutide also significantly shortened the escape latency and increased the number of hidden platform crossings in MWM test.
3 context sentences(design, population, supporting numbers)
Summary · context
Morris water maze (MWM) test was used to assess the spatial learning and memory ability.
Summary · context
The aim of this study is to explore the effects of dulaglutide on the learning and memory impairment in AD mice induced by injection of streptozocin (STZ) via intracerebroventricularly (i.c.v.).
Summary · context
32 male C57/BL6 mice were randomly divided into four groups: control group (CON); AD model group (STZ); dulaglutide treated (Dul); dulaglutide and exendin(9-39) (Ex).
Report a problemFND-3077325506

Studies that did not test the peptide alone2

In this study, Dulaglutide (Trulicity) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Dulaglutide (Trulicity).

05AnimalNot a test of Dulaglutide (Trulicity) aloneAnimal study (in vivo)Mechanism
In STZ-treated mice, tau hyperphosphorylation was lower with dulaglutide alone than with dulaglutide and exendin(9-39).
In plain wordsIn mice, tau hyperphosphorylation was lower with dulaglutide alone than with dulaglutide and exendin(9-39).
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseTau hyperphosphorylation versus antagonist regimen
Study
mousen: not reported in source
STZ-induced AD-like impairment in male C57/BL6 mice
Comparator
Dulaglutide and exendin(9-39)
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
The results displayed that the hyperphosphorylation of tau and NFs were increased in the STZ and Ex groups compared to the control and Dul groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study is to explore the effects of dulaglutide on the learning and memory impairment in AD mice induced by injection of streptozocin (STZ) via intracerebroventricularly (i.c.v.).
Summary · context
32 male C57/BL6 mice were randomly divided into four groups: control group (CON); AD model group (STZ); dulaglutide treated (Dul); dulaglutide and exendin(9-39) (Ex).
In this study, Dulaglutide (Trulicity) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dulaglutide (Trulicity).
Report a problemFND-3077325502
06AnimalNot a test of Dulaglutide (Trulicity) aloneAnimal study (in vivo)Mechanism
In STZ-treated mice, neurofilament hyperphosphorylation was lower with dulaglutide alone than with dulaglutide and exendin(9-39).
In plain wordsIn mice, neurofilament hyperphosphorylation was lower with dulaglutide alone than with dulaglutide and exendin(9-39).
Peptide
Dulaglutide (Trulicity)
Outcome
DecreaseNeurofilament hyperphosphorylation versus antagonist regimen
Study
mousen: not reported in source
STZ-induced AD-like impairment in male C57/BL6 mice
Comparator
Dulaglutide and exendin(9-39)
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
The results displayed that the hyperphosphorylation of tau and NFs were increased in the STZ and Ex groups compared to the control and Dul groups.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of this study is to explore the effects of dulaglutide on the learning and memory impairment in AD mice induced by injection of streptozocin (STZ) via intracerebroventricularly (i.c.v.).
Summary · context
32 male C57/BL6 mice were randomly divided into four groups: control group (CON); AD model group (STZ); dulaglutide treated (Dul); dulaglutide and exendin(9-39) (Ex).
In this study, Dulaglutide (Trulicity) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dulaglutide (Trulicity).
Report a problemFND-3077325504

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

PepBank is a research reference. Talk to a doctor before you use any peptide.

Dulaglutide ameliorates STZ induced AD-like impairment of learning and memory ability by modulating hyperphosphorylation of tau and NFs through GSK3β.

Summary

Results from this study6

Studies that did not test the peptide alone2

Version history

Subjects

Publication types

MeSH terms

Keywords