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Study · In vitro (cell-free) · 2019

4 results

Role of Mono- and Divalent Ions in Peptide Glu-Asp-Arg-DNA Interaction.

Silanteva IA, Komolkin AV, Morozova EA, Vorontsov-Velyaminov PN, Kasyanenko NA

The journal of physical chemistry. B22 Feb 2019Cited by 3 (Europe PMC)

PMID30762356 (opens in a new tab)DOI10.1021/acs.jpcb.8b10359 (opens in a new tab)PepBankPUB-30762356
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Mechanism

    In DNA interaction experiments, EDR partly penetrated the major groove of DNA.

    In plain wordsIn lab tests, Pinealon partly entered the major groove of DNA.

    Peptide
    Pinealon
    Outcome
    Not applicableDNA major groove penetration
    Study

    n: not reported in source

    DNA-EDR interaction
    Outcome group
    Peptide structure and chemistry · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was shown that EDR can partly penetrate into the major groove of DNA and affect the base atoms, mainly the N7 and O6 of guanine.
    1 context sentence
    Summary · context
    The interaction of the regulatory biologically active peptide Glu-Asp-Arg (EDR) with DNA is considered by spectral, NMR, viscosimetry, and molecular dynamics methods.
  2. 02LabIn vitro (cell-free)Mechanism

    In DNA interaction experiments, EDR affected base atoms, mainly guanine N7 and O6.

    In plain wordsIn lab tests, Pinealon affected DNA base atoms, mainly atoms in guanine.

    Peptide
    Pinealon
    Outcome
    Not applicableDNA base atom interaction
    Study

    n: not reported in source

    DNA-EDR interaction
    Outcome group
    Peptide structure and chemistry · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was shown that EDR can partly penetrate into the major groove of DNA and affect the base atoms, mainly the N7 and O6 of guanine.
    1 context sentence
    Summary · context
    The interaction of the regulatory biologically active peptide Glu-Asp-Arg (EDR) with DNA is considered by spectral, NMR, viscosimetry, and molecular dynamics methods.

Studies that did not test the peptide alone2

In this study, Pinealon was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Pinealon.

  1. 03LabNot a test of Pinealon aloneIn vitro (cell-free)Mechanism

    In DNA interaction experiments, magnesium ions promoted DNA-EDR interaction by screening negatively charged DNA phosphate groups.

    In plain wordsIn lab tests, magnesium promoted DNA-Pinealon interaction by screening negative charges on DNA.

    Peptide
    Pinealon
    Outcome
    IncreaseMagnesium promotion of DNA-EDR interaction
    Study

    n: not reported in source

    DNA-EDR interaction
    Outcome group
    Peptide structure and chemistry · Pharmacology

    Source sentences

    Summary
    It was observed that Mg2+ ions can promote DNA-EDR interaction due to their effective screening of the negatively charged phosphate groups of DNA.
    1 context sentence
    Summary · context
    The interaction of the regulatory biologically active peptide Glu-Asp-Arg (EDR) with DNA is considered by spectral, NMR, viscosimetry, and molecular dynamics methods.

    In this study, Pinealon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pinealon.

  2. 04LabNot a test of Pinealon aloneIn vitro (cell-free)Mechanism

    In DNA interaction experiments, magnesium promotion of DNA-EDR interaction persisted in salted solution.

    In plain wordsIn lab tests, magnesium promotion of DNA-Pinealon interaction persisted in salted solution.

    Peptide
    Pinealon
    Outcome
    Not applicableMagnesium action in salted solution
    Study

    n: not reported in source

    DNA-EDR interaction
    Outcome group
    Peptide structure and chemistry · Pharmacology

    Source sentences

    Summary
    This action of Mg2+ remains in salted solution as well.
    2 context sentences
    Summary · context
    It was observed that Mg2+ ions can promote DNA-EDR interaction due to their effective screening of the negatively charged phosphate groups of DNA.
    Summary · context
    The interaction of the regulatory biologically active peptide Glu-Asp-Arg (EDR) with DNA is considered by spectral, NMR, viscosimetry, and molecular dynamics methods.

    In this study, Pinealon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Pinealon.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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