In male mice under chronic social defeat stress, chronic delivery of the GHSR agonist GHRP‑2 during and after stress did not improve depressive-like behavior.
In plain wordsIn mice under chronic social stress, GHRP‑2 given during and after the stress did not improve depressive-like behavior.
- Peptide
- GHRP-2
- Outcome
- No significant changeDepressive-like behavior after chronic GHRP-2 delivery in CSDS
- Study
mousen: not reported in source
10-day chronic social defeat stress (CSDS) in male mice- Outcome group
- Anxiety and mood · Mental health and mood
- Studied dose
- Dose not stated · during and after CSDSAs given in this study (mouse).
Source sentences
nor chronic delivery of GHRP-2 during and after CSDS improved stress-induced depressive-like behavior
2 context sentences(design, population, supporting numbers)
the synthetic GHSR agonist GHRP-2 during and/or after CSDS.
Here, we used a pharmacological approach in combination with a 10-day chronic social defeat stress (CSDS) model in male mice to investigate whether the sympathoadrenal system is involved in the ghrelin response to stress.