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Study · In vitro (cells) · 2019

2 results

ARPE-19-derived VEGF-containing exosomes promote neovascularization in HUVEC: the role of the melanocortin receptor 5.

Maisto R, Oltra M, Vidal-Gil L, Martínez-Gil N, Sancho-Pellúz J, Filippo CD, Rossi S, D Amico M, Barcia JM, Romero FJ

Cell cycle (Georgetown, Tex.)9 Feb 2019Cited by 36 (Europe PMC)

PMID30739530 (opens in a new tab)PMCIDPMC6422460 (opens in a new tab)DOI10.1080/15384101.2019.1568745 (opens in a new tab)PepBankPUB-30739530
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In ARPE-19 cells cultured in high glucose, the mixed MCR3/4 agonist MTII did not significantly decrease ROS levels.

    In plain wordsIn lab-grown retinal cells in high glucose, MTII did not significantly lower ROS levels.

    Peptide
    Melanotan II
    Outcome
    No significant changeROS levels in high-glucose ARPE-19 cells
    Study

    n: not reported in source

    ARPE-19 retinal pigment epithelial cells in high glucose
    Outcome group
    Oxidative stress · Eye
    Studied dose
    0.30 nmolAs given in this study.

    Source sentences

    Summary
    In contrast, incubating the cells with the melanocortin receptor MCR1 agonist BMS-470539 (10-5 M) or with the mixed MCR3/4 agonist MTII (0.30 nmol) did not produce any significant decrease in ROS levels.
    1 context sentence
    Summary · context
    ARPE-19 retinal pigment epithelial cells cultured in a medium containing 35 mM D-glucose led to an augmented ROS formation and release of vascular endothelial factor (VEGF)-containing exosomes compared to ARPE-19 cells cultured in a medium containing 5 mM D-glucose (standard medium).
  2. 02LabIn vitro (cells)Mechanism

    MTII did not reduce the neovascularization that ARPE-19-derived VEGF-containing exosomes promoted in HUVEC.

    In plain wordsIn lab tests, MTII did not reduce new blood vessel growth in human vein cells that was driven by exosomes from retinal cells.

    Peptide
    Melanotan II
    Outcome
    No significant changeExosome-induced neovascularization in HUVEC
    Study

    humann: not reported in source

    HUVEC exposed to ARPE-19-derived VEGF-containing exosomes
    Outcome group
    Angiogenesis · Eye
    Studied dose
    0.30 nmolAs given in this study (human).

    Source sentences

    Summary
    an effect that was markedly reduced by PG-901 (10-10M) but not by the MCR3/4 agonist MTII (0.30 nmol) or the MCR1 agonist BMS-470539 (10-5 M).
    1 context sentence
    Summary · context
    ARPE-19 retinal pigment epithelial cells cultured in a medium containing 35 mM D-glucose led to an augmented ROS formation and release of vascular endothelial factor (VEGF)-containing exosomes compared to ARPE-19 cells cultured in a medium containing 5 mM D-glucose (standard medium).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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