In 15 healthy men, oxytocin reversed the causal influence of the bilateral precuneus on the left dorsolateral prefrontal cortex from negative under placebo to positive; the effect was statistically significant for the right precuneus.
In plain wordsIn healthy men, oxytocin changed how the precuneus brain region influenced the left prefrontal region, compared with placebo.
- Peptide
- Oxytocin
- Outcome
- IncreaseEffective connectivity from bilateral precuneus to left dlPFC
- Study
n = 15
- Comparator
- Placebo
- Outcome group
- Brain and neuronal activity · Nervous system and cognition
- Studied dose
- 24 IU · single doseAs given in this study (human).
Source sentences
However, under oxytocin, these patterns were reversed, i.e. positive causal influence from the bilateral precuneus to the left dlPFC and negative causal influence from the left dlPFC to the bilateral precuneus (with statistically significant effects for the right precuneus).
2 context sentences(design, population, supporting numbers)
Under placebo, the bilateral precuneus exerted a significant negative causal influence on the left dlPFC and the left dlPFC exerted a significant positive causal influence on the bilateral precuneus.
We test this hypothesis using a randomized, double-blind, crossover, placebo-controlled trial where 15 healthy male participants received 24 IU oxytocin or placebo prior to a resting-state functional MRI scan.