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Study · Animal study (in vivo) · mouse · 2019

11 results

MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction.

Lu H, Wei M, Zhai Y, Li Q, Ye Z, Wang L, Luo W, Chen J, Lu Z

Journal of molecular medicine (Berlin, Germany)6 Feb 2019Cited by 71 (Europe PMC)

PMID30725119 (opens in a new tab)DOI10.1007/s00109-018-01738-w (opens in a new tab)PepBankPUB-30725119
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized mice, MOTS‑c treatment prevented ovariectomy-induced obesity.

    In plain wordsIn mice with removed ovaries, MOTS‑c treatment prevented the weight gain that this surgery normally causes.

    Peptide
    MOTS-c
    Outcome
    DecreaseOvariectomy-induced obesity
    Study

    mousen: not reported in source

    ovariectomy-induced metabolic dysfunction
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we showed that MOTS-c treatment in mice prevented ovariectomy-induced obesity and insulin resistance.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized mice, MOTS‑c treatment prevented ovariectomy-induced insulin resistance.

    In plain wordsIn mice with removed ovaries, MOTS‑c treatment prevented the insulin resistance that this surgery normally causes.

    Peptide
    MOTS-c
    Outcome
    DecreaseOvariectomy-induced insulin resistance
    Study

    mousen: not reported in source

    ovariectomy-induced metabolic dysfunction
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we showed that MOTS-c treatment in mice prevented ovariectomy-induced obesity and insulin resistance.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized mice, MOTS‑c treatment increased brown fat activation.

    In plain wordsIn mice with removed ovaries, MOTS‑c treatment increased the activity of brown fat.

    Peptide
    MOTS-c
    Outcome
    IncreaseBrown fat activation
    Study

    mousen: not reported in source

    ovariectomy-induced metabolic dysfunction
    Outcome group
    Fat metabolism and adipogenesis · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c treatment increased brown fat activation and reduced OVX-induced fat accumulation and inflammatory invasion in white adipose tissue, which contributes to the lower level of fatty acid in serum and liver.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized mice, MOTS‑c treatment reduced ovariectomy-induced fat accumulation in white adipose tissue.

    In plain wordsIn mice with removed ovaries, MOTS‑c treatment reduced the build-up of white fat.

    Peptide
    MOTS-c
    Outcome
    DecreaseOVX-induced fat accumulation in white adipose tissue
    Study

    mousen: not reported in source

    ovariectomy-induced metabolic dysfunction
    Outcome group
    Fat metabolism and adipogenesis · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c treatment increased brown fat activation and reduced OVX-induced fat accumulation and inflammatory invasion in white adipose tissue, which contributes to the lower level of fatty acid in serum and liver.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized mice, MOTS‑c treatment reduced inflammatory invasion in white adipose tissue.

    In plain wordsIn mice with removed ovaries, MOTS‑c treatment reduced inflammatory cell invasion into white fat.

    Peptide
    MOTS-c
    Outcome
    DecreaseInflammatory invasion in white adipose tissue
    Study

    mousen: not reported in source

    ovariectomy-induced metabolic dysfunction
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c treatment increased brown fat activation and reduced OVX-induced fat accumulation and inflammatory invasion in white adipose tissue, which contributes to the lower level of fatty acid in serum and liver.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized mice, MOTS‑c treatment was linked to a lower level of fatty acid in serum.

    In plain wordsIn mice with removed ovaries, MOTS‑c treatment was linked to lower fatty acid levels in blood.

    Peptide
    MOTS-c
    Outcome
    DecreaseSerum fatty acid level
    Study

    mousen: not reported in source

    ovariectomy-induced metabolic dysfunction
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c treatment increased brown fat activation and reduced OVX-induced fat accumulation and inflammatory invasion in white adipose tissue, which contributes to the lower level of fatty acid in serum and liver.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized mice, MOTS‑c treatment was linked to a lower level of fatty acid in the liver.

    In plain wordsIn mice with removed ovaries, MOTS‑c treatment was linked to lower fatty acid levels in the liver.

    Peptide
    MOTS-c
    Outcome
    DecreaseLiver fatty acid level
    Study

    mousen: not reported in source

    ovariectomy-induced metabolic dysfunction
    Outcome group
    Lipids · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MOTS-c treatment increased brown fat activation and reduced OVX-induced fat accumulation and inflammatory invasion in white adipose tissue, which contributes to the lower level of fatty acid in serum and liver.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In ovariectomized mice, MOTS‑c activated the AMPK pathway.

    In plain wordsIn mice with removed ovaries, MOTS‑c switched on the AMPK energy pathway.

    Peptide
    MOTS-c
    Outcome
    IncreaseAMPK pathway activation
    Study

    mousen: not reported in source

    ovariectomy-induced metabolic dysfunction
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, MOTS-c activated AMPK pathway to improve energy dissipation and insulin sensitivity.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized mice, MOTS‑c activated AMPK to improve energy dissipation.

    In plain wordsIn mice with removed ovaries, MOTS‑c improved how the body burns off energy.

    Peptide
    MOTS-c
    Outcome
    IncreaseEnergy dissipation
    Study

    mousen: not reported in source

    ovariectomy-induced metabolic dysfunction
    Outcome group
    Fat metabolism and adipogenesis · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, MOTS-c activated AMPK pathway to improve energy dissipation and insulin sensitivity.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized mice, MOTS‑c activated AMPK to improve insulin sensitivity.

    In plain wordsIn mice with removed ovaries, MOTS‑c improved insulin sensitivity.

    Peptide
    MOTS-c
    Outcome
    IncreaseInsulin sensitivity
    Study

    mousen: not reported in source

    ovariectomy-induced metabolic dysfunction
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, MOTS-c activated AMPK pathway to improve energy dissipation and insulin sensitivity.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In the ovariectomy mouse study, a blocker of the AMPK pathway attenuated the role of MOTS‑c in the regulation of adipocyte lipid metabolism.

    In plain wordsIn this mouse study, a drug that blocks the AMPK pathway weakened the effect of MOTS‑c on fat cell fat handling.

    Peptide
    MOTS-c
    Outcome
    Not applicableAdipocyte lipid metabolism with AMPK blocker
    Study

    mousen: not reported in source

    ovariectomy-induced metabolic dysfunction
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    And a blocker of AMPK pathway was found to attenuate the role of MOTS-c in the regulation of adipocyte lipid metabolism.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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