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Study · Animal study (in vivo) · pig · 2019

2 results

C-X-C Motif Chemokine Receptor 4 Blockade Promotes Tissue Repair After Myocardial Infarction by Enhancing Regulatory T Cell Mobilization and Immune-Regulatory Function.

Wang Y, Dembowsky K, Chevalier E, Stüve P, Korf-Klingebiel M, Lochner M, Napp LC, Frank H, Brinkmann E, Kanwischer A, Bauersachs J, Gyöngyösi M, Sparwasser T, Wollert KC

Circulation1 Apr 2019Cited by 107 (Europe PMC)

PMID30696265 (opens in a new tab)PMCIDPMC6467561 (opens in a new tab)DOI10.1161/circulationaha.118.036053 (opens in a new tab)PepBankPUB-30696265
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with reperfused myocardial infarction, POL6326 decreased infarct volume.

    In plain wordsIn pigs with heart injury, POL6326 decreased infarct volume.

    Peptide
    Balixafortide
    Outcome
    DecreaseInfarct volume
    Study

    pign: not reported in source

    reperfused myocardial infarction
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    3 mg/kg at 4, 6, 8, and 10 days · intravenous infusionAs given in this study (pig).

    Source sentences

    Summary
    Intravenous infusion of the clinical-stage POL5551 analogue POL6326 (3 mg/kg at 4, 6, 8, and 10 days) decreased infarct volume and improved left ventricular ejection fraction in pigs.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In pigs with reperfused myocardial infarction, POL6326 improved left ventricular ejection fraction.

    In plain wordsIn pigs with heart injury, POL6326 improved the heart's pumping fraction.

    Peptide
    Balixafortide
    Outcome
    IncreaseLeft ventricular ejection fraction
    Study

    pign: not reported in source

    reperfused myocardial infarction
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    3 mg/kg at 4, 6, 8, and 10 days · intravenous infusionAs given in this study (pig).

    Source sentences

    Summary
    Intravenous infusion of the clinical-stage POL5551 analogue POL6326 (3 mg/kg at 4, 6, 8, and 10 days) decreased infarct volume and improved left ventricular ejection fraction in pigs.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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