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Study · In vitro (cells) · mouse · 2019

2 results

Effect of the PTHrP(1-34) analog abaloparatide on inducing chondrogenesis involves inhibition of intracellular reactive oxygen species production.

Yang Y, Lei H, Wang B

Biochemical and biophysical research communications14 Jan 2019Cited by 11 (Europe PMC)

PMID30654932 (opens in a new tab)PMCIDPMC7768806 (opens in a new tab)DOI10.1016/j.bbrc.2019.01.049 (opens in a new tab)PepBankPUB-30654932
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In mouse mesenchymal stem cell cultures, abaloparatide stimulated chondrogenesis.

    In plain wordsIn cells from mouse limb buds, abaloparatide stimulated cartilage formation.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    IncreaseChondrogenesis
    Study

    mousen: not reported in source

    Embryonic limb bud mesenchymal stem cell micromass cultures
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The effect of ABL on stimulation of chondrogenesis is involved in its inhibition of intracellular ROS generation.
    1 context sentence
    Summary · context
    By using mouse embryonic limb bud mesenchymal stem cells in micromass culture as an in vitro model of chondrogenic differentiation, we found that mesenchymal stem cells in micromass cultures spontaneously produced ROS, and N-acetyl-l-cysteine, a potent antioxidant, enhanced chondrogenesis.
  2. 02LabIn vitro (cells)Mechanism

    In mouse mesenchymal stem cell cultures, abaloparatide inhibited intracellular ROS generation in association with chondrogenesis stimulation.

    In plain wordsIn cells from mouse limb buds, abaloparatide reduced intracellular reactive oxygen species during cartilage formation.

    Peptide
    Abaloparatide (Tymlos)
    Outcome
    DecreaseIntracellular ROS generation
    Study

    mousen: not reported in source

    Embryonic limb bud mesenchymal stem cell micromass cultures
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The effect of ABL on stimulation of chondrogenesis is involved in its inhibition of intracellular ROS generation.
    1 context sentence
    Summary · context
    By using mouse embryonic limb bud mesenchymal stem cells in micromass culture as an in vitro model of chondrogenic differentiation, we found that mesenchymal stem cells in micromass cultures spontaneously produced ROS, and N-acetyl-l-cysteine, a potent antioxidant, enhanced chondrogenesis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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