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Study · Randomized controlled trial · n = 58 · 2019

5 results

The Effects of Oxytocin on Withdrawal, Craving and Stress Response in Heroin-Dependent Patients: A Randomized, Double-Blind Clinical Trial.

Moeini M, Omidi A, Sehat M, Banafshe HR

European addiction research10 Jan 2019Cited by 45 (Europe PMC)

PMID30630161 (opens in a new tab)DOI10.1159/000496194 (opens in a new tab)PepBankPUB-30630161
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In heroin-dependent men, a single dose of intranasal oxytocin reduced craving scores versus placebo.

    In plain wordsIn men dependent on heroin, one dose of oxytocin lowered craving scores compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseCraving score
    Study

    n = 58

    Comparator
    Placebo
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Acute OT administration reduced craving and withdrawal scores
    2 context sentences
    Summary · context
    This randomized, double-blind placebo-controlled clinical trial was conducted on 58 males with opioid dependence by Abstinence Center of Addictive People in Iran.
    Summary · context
    The participants were randomly allocated to receive intranasal OT (single dose; 40 IU, n = 29) or placebo (n = 29).
  2. 02HumanRandomized controlled trialEfficacy outcome

    In heroin-dependent men, a single dose of intranasal oxytocin reduced withdrawal scores versus placebo.

    In plain wordsIn men dependent on heroin, one dose of oxytocin lowered withdrawal scores compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseWithdrawal score
    Study

    n = 58

    Comparator
    Placebo
    Outcome group
    Addiction, withdrawal and alcohol intake · Mental health and mood
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Acute OT administration reduced craving and withdrawal scores
    2 context sentences
    Summary · context
    This randomized, double-blind placebo-controlled clinical trial was conducted on 58 males with opioid dependence by Abstinence Center of Addictive People in Iran.
    Summary · context
    The participants were randomly allocated to receive intranasal OT (single dose; 40 IU, n = 29) or placebo (n = 29).
  3. 03HumanRandomized controlled trialEfficacy outcome

    In heroin-dependent men, a single dose of intranasal oxytocin did not change anxiety scores significantly.

    In plain wordsIn men dependent on heroin, one dose of oxytocin did not change anxiety scores significantly compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeAnxiety score
    Study

    n = 58

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    but did not change anxiety significantly.
    2 context sentences
    Summary · context
    This randomized, double-blind placebo-controlled clinical trial was conducted on 58 males with opioid dependence by Abstinence Center of Addictive People in Iran.
    Summary · context
    The participants were randomly allocated to receive intranasal OT (single dose; 40 IU, n = 29) or placebo (n = 29).
  4. 04HumanRandomized controlled trialMechanism

    In heroin-dependent men during abstinence, a single dose of oxytocin decreased cortisol levels.

    In plain wordsIn men dependent on heroin, one dose of oxytocin lowered cortisol levels during abstinence.

    Peptide
    Oxytocin
    Outcome
    DecreaseBlood cortisol level
    Study

    n = 58

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Single dose of OT decreased the level of cortisol and improved the cortisol/DHEAS ratio in the heroin users during abstinence (p < 0.01).
    2 context sentences
    Summary · context
    This randomized, double-blind placebo-controlled clinical trial was conducted on 58 males with opioid dependence by Abstinence Center of Addictive People in Iran.
    Summary · context
    The participants were randomly allocated to receive intranasal OT (single dose; 40 IU, n = 29) or placebo (n = 29).
  5. 05HumanRandomized controlled trialMechanism

    In heroin-dependent men during abstinence, a single dose of oxytocin improved the cortisol/DHEAS ratio.

    In plain wordsIn men dependent on heroin, one dose of oxytocin improved the balance of two stress hormones during abstinence.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedCortisol/DHEAS ratio
    Study

    n = 58

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Single dose of OT decreased the level of cortisol and improved the cortisol/DHEAS ratio in the heroin users during abstinence (p < 0.01).
    2 context sentences
    Summary · context
    This randomized, double-blind placebo-controlled clinical trial was conducted on 58 males with opioid dependence by Abstinence Center of Addictive People in Iran.
    Summary · context
    The participants were randomly allocated to receive intranasal OT (single dose; 40 IU, n = 29) or placebo (n = 29).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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