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Study · Randomized controlled trial · n = 34 · 2019

4 results

Intranasal oxytocin modulates higher order social cognition in body dysmorphic disorder.

Fang A, Lawson EA, Wilhelm S

Depression and anxiety7 Jan 2019Cited by 11 (Europe PMC)

PMID30614171 (opens in a new tab)PMCIDPMC6501211 (opens in a new tab)DOI10.1002/da.22876 (opens in a new tab)PepBankPUB-30614171
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adults with body dysmorphic disorder, the oxytocin effect on internal attributions in other-referent contexts was greater than in healthy controls.

    In plain wordsIn adults with body dysmorphic disorder, oxytocin led to more internal attributions about others than the effect it had in healthy controls.

    Peptide
    Oxytocin
    Outcome
    IncreaseInternal attributions in other-referent contexts
    Study

    n = 34

    Comparator
    Healthy controls
    Outcome group
    Cognition and memory · Mental health and mood
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    However, oxytocin led to greater internal attributions in other-referent contexts for those with BDD compared to HCs.
    1 context sentence
    Summary · context
    Eighteen participants with BDD and 16 HCs received a single dose of 24 international units of intranasal oxytocin (Syntocinon®) or matching placebo in a randomized, placebo-controlled, within-subject crossover design.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adults with body dysmorphic disorder, a single dose of intranasal oxytocin did not improve emotion recognition accuracy versus placebo in self-referent or other-referent contexts.

    In plain wordsIn adults with body dysmorphic disorder, one dose of oxytocin did not improve emotion recognition compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeEmotion recognition accuracy (self-referent and other-referent)
    Study

    n = 18

    Comparator
    Placebo
    Outcome group
    Cognition and memory · Mental health and mood
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Oxytocin, relative to placebo, did not improve emotion recognition accuracy in either self-referent or other-referent contexts for individuals with BDD.
    1 context sentence
    Summary · context
    Eighteen participants with BDD and 16 HCs received a single dose of 24 international units of intranasal oxytocin (Syntocinon®) or matching placebo in a randomized, placebo-controlled, within-subject crossover design.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In adults with body dysmorphic disorder, oxytocin led to other-directed blame rather than reducing self-blame.

    In plain wordsIn adults with body dysmorphic disorder, oxytocin led to blaming others rather than reducing self-blame.

    Peptide
    Oxytocin
    Outcome
    IncreaseBlame direction (other-directed blame)
    Study

    n = 18

    Outcome group
    Social behavior and cognition · Mental health and mood
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Rather than reducing self-blame, oxytocin led to other-directed blame.
    1 context sentence
    Summary · context
    Eighteen participants with BDD and 16 HCs received a single dose of 24 international units of intranasal oxytocin (Syntocinon®) or matching placebo in a randomized, placebo-controlled, within-subject crossover design.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In adults with body dysmorphic disorder, oxytocin did not change threat interpretations.

    In plain wordsIn adults with body dysmorphic disorder, oxytocin did not change how threatening situations were interpreted.

    Peptide
    Oxytocin
    Outcome
    No significant changeThreat interpretations
    Study

    n = 18

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Oxytocin did not impact threat interpretations in BDD.
    1 context sentence
    Summary · context
    Eighteen participants with BDD and 16 HCs received a single dose of 24 international units of intranasal oxytocin (Syntocinon®) or matching placebo in a randomized, placebo-controlled, within-subject crossover design.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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