[The influence of peptides on the morphofunctional state of old rats kidneys.]

Zamorskii II, Shchudrova TS, Zeleniuk VG, Linkova NS, Nichik TE, Khavinson VK

Advances in gerontology = Uspekhi gerontologii1 Jan 2018Cited by 1 (Europe PMC)

PMID30607912PepBankPUB-30607912

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study18

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In old rats, the peptide AEDG reduced glomerular filtration rate by 21%.
In plain wordsIn old rats, the peptide AEDG lowered the kidney filtration rate by 21%.
Peptide
Epitalon
Outcome
DecreaseGlomerular filtration rate
Study
ratn: not reported in source
Old rat kidney function
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated
Measurements
GFR change
21%
decrease, AEDG
Source sentences
Summary
a reduction of glomerular filtration rate by 21%
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
Report a problemFND-3060791201
02AnimalAnimal study (in vivo)Efficacy outcome
In old rats, the peptide AEDG decreased urine protein level by 3,1 times.
In plain wordsIn old rats, the peptide AEDG lowered the protein level in urine.
Peptide
Epitalon
Outcome
DecreaseUrine protein level
Study
ratn: not reported in source
Old rat kidney function
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
decrease in urine protein level by 3,1 times
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
Report a problemFND-3060791202
03AnimalAnimal study (in vivo)Efficacy outcome
In old rats, the peptide AEDG decreased protein excretion by 2,5 times.
In plain wordsIn old rats, the peptide AEDG lowered the amount of protein lost in urine.
Peptide
Epitalon
Outcome
DecreaseUrine protein excretion
Study
ratn: not reported in source
Old rat kidney function
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
protein excretion - by 2,5 times.
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
Report a problemFND-3060791203
04AnimalAnimal study (in vivo)Efficacy outcome
In old rats, the peptide AEDG reduced absolute sodium reabsorption by 1,3 times.
In plain wordsIn old rats, the peptide AEDG reduced sodium reabsorption in the kidney.
Peptide
Epitalon
Outcome
DecreaseAbsolute sodium reabsorption
Study
ratn: not reported in source
Old rat kidney function
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
Peptide AEDG reduced absolute sodium reabsorption by 1,3 times
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
Report a problemFND-3060791204
05AnimalAnimal study (in vivo)Efficacy outcome
In old rats, the peptide AEDG increased distal sodium transport by 1,4 times.
In plain wordsIn old rats, the peptide AEDG increased sodium transport in the distal part of the kidney.
Peptide
Epitalon
Outcome
IncreaseDistal sodium transport
Study
ratn: not reported in source
Old rat kidney function
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
and increased distal sodium transport by 1,4 times.
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
Report a problemFND-3060791205
06AnimalAnimal study (in vivo)Efficacy outcome
In old rats, AED increased sodium excretion by 1,3 times.
In plain wordsIn old rats, AED increased sodium excretion.
Peptide
Cartalax
Outcome
IncreaseSodium excretion
Study
ratn: not reported in source
old rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated
Source sentences
Summary
Peptides AED and EDL increased sodium excretion by 1,3 and 1,6 times, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
Report a problemFND-3060791213
07AnimalAnimal study (in vivo)Efficacy outcome
In old rats, EDL increased sodium excretion by 1.6 times.
In plain wordsIn old rats, EDL increased sodium excretion.
Peptide
Ovagen (EDL)
Outcome
IncreaseSodium excretion
Study
ratn: not reported in source
old rats
Outcome group
Kidney function · Kidney and urinary
Studied dose
Dose not stated
Measurements
Sodium excretion increase
1.6 times
EDL
Source sentences
Summary
Peptides AED and EDL increased sodium excretion by 1,3 and 1,6 times, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
Report a problemFND-3060791218

Studies that did not test the peptide alone11

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

08AnimalNot a test of Epitalon aloneAnimal study (in vivo)Mechanism
In old rat kidney tissue, the studied preparations (polypeptide kidney complex and peptides) stimulated antioxidant enzyme activity.
In plain wordsIn old rats, the studied preparations raised antioxidant enzyme activity in kidney tissue. The abstract does not split this result by peptide.
Peptide
Epitalon
Outcome
IncreaseKidney antioxidant enzyme activity
Study
ratn: not reported in source
Old rat kidney function
Outcome group
Oxidative stress · Kidney and urinary
Source sentences
Summary
In kidney tissue a stimulation of the antioxidant enzymes activity on the background of inhibition of the peroxidation processes intensity was observed
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-3060791206
09AnimalNot a test of Epitalon aloneAnimal study (in vivo)Mechanism
In old rat kidney tissue, the studied preparations (polypeptide kidney complex and peptides) inhibited the intensity of peroxidation.
In plain wordsIn old rats, the studied preparations lowered peroxidation in kidney tissue. The abstract does not split this result by peptide.
Peptide
Epitalon
Outcome
DecreaseKidney lipid peroxidation intensity
Study
ratn: not reported in source
Old rat kidney function
Outcome group
Oxidative stress · Kidney and urinary
Source sentences
Summary
In kidney tissue a stimulation of the antioxidant enzymes activity on the background of inhibition of the peroxidation processes intensity was observed
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-3060791207
10AnimalNot a test of Epitalon aloneAnimal study (in vivo)Safety outcome
In old rats, kidney morphology and enzyme data of the studied preparations (polypeptide kidney complex and peptides) showed no nephrotoxic effects.
In plain wordsIn old rats, the studied preparations showed no signs of kidney toxicity. The abstract does not split this result by peptide.
Peptide
Epitalon
Outcome
No significant changeNephrotoxic effects
Study
ratn: not reported in source
Old rat kidney function
Outcome group
Adverse events · Kidney and urinary
Source sentences
Summary
which in complex with morphological data evidences the absence of nephrotoxic effects.
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-3060791208
11AnimalNot a test of Cartalax aloneAnimal study (in vivo)Efficacy outcome
In old rats, PKC, AED and EDL increased diuresis by 1,2-1,4 times, without separate agent-specific estimates.
In plain wordsIn old rats, PKC, AED and EDL increased urine production, without separate estimates for each agent.
Peptide
Cartalax
Outcome
IncreaseDiuresis
Study
ratn: not reported in source
old rats
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
Administration of PKC, peptides AED and EDL increased diuresis by 1,2-1,4 times.
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
In this study, Cartalax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cartalax.
Report a problemFND-3060791209
12AnimalNot a test of Cartalax aloneAnimal study (in vivo)Efficacy outcome
In old rats, PKC and AED reduced urine protein level by 1,5-2,8 times, without separate agent-specific estimates.
In plain wordsIn old rats, PKC and AED reduced urine protein levels, without separate estimates for each agent.
Peptide
Cartalax
Outcome
DecreaseUrine protein level
Study
ratn: not reported in source
old rats
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
PKC and peptide AED reduced urine protein level and protein excretion by 1,5-2,8 times.
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
In this study, Cartalax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cartalax.
Report a problemFND-3060791210
13AnimalNot a test of Cartalax aloneAnimal study (in vivo)Efficacy outcome
In old rats, PKC and AED reduced protein excretion by 1,5-2,8 times, without separate agent-specific estimates.
In plain wordsIn old rats, PKC and AED reduced protein excretion, without separate estimates for each agent.
Peptide
Cartalax
Outcome
DecreaseProtein excretion
Study
ratn: not reported in source
old rats
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
PKC and peptide AED reduced urine protein level and protein excretion by 1,5-2,8 times.
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
In this study, Cartalax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cartalax.
Report a problemFND-3060791211
14AnimalNot a test of Cartalax aloneAnimal study (in vivo)Efficacy outcome
In old rats, PKC, AED and EDL increased distal sodium transport by 1,2-1,3 times, without separate agent-specific estimates.
In plain wordsIn old rats, PKC, AED and EDL increased distal sodium transport, without separate estimates for each agent.
Peptide
Cartalax
Outcome
IncreaseDistal sodium transport
Study
ratn: not reported in source
old rats
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
PKC, peptides AED and EDL increased distal sodium transport by 1,2-1,3 times.
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
In this study, Cartalax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cartalax.
Report a problemFND-3060791212
15AnimalNot a test of Cartalax aloneAnimal study (in vivo)Mechanism
In old rat kidney tissue, the study of PKC, AED, EDL and AEDG reported increased antioxidant enzyme activity without agent-specific results.
In plain wordsIn old rats, the study of PKC and peptides including AED reported increased kidney antioxidant enzyme activity.
Peptide
Cartalax
Outcome
IncreaseAntioxidant enzyme activity
Study
ratn: not reported in source
old rats
Outcome group
Oxidative stress · Kidney and urinary
Source sentences
Summary
In kidney tissue a stimulation of the antioxidant enzymes activity on the background of inhibition of the peroxidation processes intensity was observed
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
In this study, Cartalax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cartalax.
Report a problemFND-3060791214
16AnimalNot a test of Cartalax aloneAnimal study (in vivo)Mechanism
In old rat kidney tissue, the study of PKC, AED, EDL and AEDG reported inhibited peroxidation without agent-specific results.
In plain wordsIn old rats, the study of PKC and peptides including AED reported reduced kidney peroxidation.
Peptide
Cartalax
Outcome
DecreasePeroxidation intensity
Study
ratn: not reported in source
old rats
Outcome group
Oxidative stress · Kidney and urinary
Source sentences
Summary
In kidney tissue a stimulation of the antioxidant enzymes activity on the background of inhibition of the peroxidation processes intensity was observed
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
In this study, Cartalax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cartalax.
Report a problemFND-3060791215
17AnimalNot a test of Cartalax aloneAnimal study (in vivo)Safety outcome
In old rats, biochemical and morphological data indicated no nephrotoxic effects in the study of PKC, AED, EDL and AEDG.
In plain wordsIn old rats, the study of PKC and peptides including AED found no evidence of kidney toxicity.
Peptide
Cartalax
Outcome
Not applicableNephrotoxicity
Study
ratn: not reported in source
old rats
Outcome group
Adverse events · Kidney and urinary
Source sentences
Summary
In kidney tissue a stimulation of the antioxidant enzymes activity on the background of inhibition of the peroxidation processes intensity was observed, which in complex with morphological data evidences the absence of nephrotoxic effects.
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
In this study, Cartalax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cartalax.
Report a problemFND-3060791216
18AnimalNot a test of Cartalax aloneAnimal study (in vivo)Mechanism
In old rats, correlations between glomerular filtration and sodium reabsorption supported glomerular-tubular and tubular-tubular balances, without an AED-specific result.
In plain wordsIn old rats, correlations between kidney filtration and sodium reabsorption supported coordinated kidney function, without a separate AED result.
Peptide
Cartalax
Outcome
Not applicableGlomerular-tubular and tubular-tubular balances
Study
ratn: not reported in source
old rats
Outcome group
Kidney function · Kidney and urinary
Source sentences
Summary
Realization of glomerular-tubular and tubular-tubular balances is verified by correlation between glomerular filtration rate (GFR) and absolute sodium reabsorption, proximal and distal sodium reabsorption.
1 context sentence(design, population, supporting numbers)
Summary · context
An influence of polypeptide kidney complex (PKC), peptides AED, EDL, AEDG on the functional state of old rats kidneys was studied in research.
In this study, Cartalax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cartalax.
Report a problemFND-3060791217

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Versions 8 to 15Current
28 Oct 2026, 02:02 UTC
The same notice was added 8 times, first on 21 Oct 2026, 17:05 UTC. The status did not change between them.
Study results updated
Version 7
21 Oct 2026, 16:35 UTC
Study data updated · source update from Europe PMC
Versions 4 to 6
21 Oct 2026, 15:58 UTC
The same notice was added 3 times, first on 14 Oct 2026, 05:02 UTC. The status did not change between them.
Study results updated
Version 3
14 Oct 2026, 01:46 UTC
Study data updated · source update from Europe PMC
Version 2
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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