Effect of Palmitoyl-Pentapeptide (Pal-KTTKS) on Wound Contractile Process in Relation with Connective Tissue Growth Factor and α-Smooth Muscle Actin Expression.

Park H, An E, Cho Lee AR

Tissue engineering and regenerative medicine19 Jan 2017Cited by 10 (Europe PMC)

PMID30603464PMCIDPMC6171572DOI10.1007/s13770-016-0017-yPepBankPUB-30603464

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In fibroblasts, Pal-KTTKS reduced α-SMA-positive stress fibers versus no Pal-KTTKS treatment.
In plain wordsIn cells, Pal-KTTKS reduced scar-associated stress fibers compared with untreated cells.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
Decreaseα-SMA-positive stress fibers
Study
n = 3
Fibroblasts
Comparator
Without Pal-KTTKS treatment
Outcome group
Wound healing · Skin and wound
Studied dose
0.1 µMAs given in this study.
Measurements
α-SMA-positive stress fibers
75%
without Pal-KTTKS
α-SMA-positive stress fibers
38.6%
0.1 µM Pal-KTTKS
Source sentences
Summary
Without Pal-KTTKS treatment, three quarters of the fibroblasts differentiates into the myofibroblast; α-SMA-positive stress fibers per field decreased twofold with 0.1 µM Pal-KTTKS treatment (75 ± 7.1 vs 38.6 ± 16.1%, n = 3, p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
The extent of α-SMA-positive fibroblasts was determined in collagen lattices and in cell culture study.
Report a problemFND-3060346401
02LabIn vitro (cells)Mechanism
In fibroblasts, Pal-KTTKS did not significantly inhibit α-SMA-positive stress fibers at the higher tested concentration.
In plain wordsIn cells, the higher Pal-KTTKS concentration did not significantly reduce stress fibers compared with untreated cells.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
No significant changeα-SMA-positive stress fiber inhibition
Study
n: not reported in source
Fibroblasts
Comparator
Without Pal-KTTKS treatment
Outcome group
Wound healing · Skin and wound
Studied dose
0.5 µMAs given in this study.
Source sentences
Summary
The inhibitory effect was not significant in 0.5 µM Pal-KTTKS treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Without Pal-KTTKS treatment, three quarters of the fibroblasts differentiates into the myofibroblast; α-SMA-positive stress fibers per field decreased twofold with 0.1 µM Pal-KTTKS treatment (75 ± 7.1 vs 38.6 ± 16.1%, n = 3, p < 0.05).
Summary · context
The extent of α-SMA-positive fibroblasts was determined in collagen lattices and in cell culture study.
Report a problemFND-3060346402

Studies that did not test the peptide alone2

In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Matrixyl (palmitoyl pentapeptide-4).

03LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Mechanism
In fibroblast experiments involving Pal-KTTKS, stress fiber levels correlated with α-SMA expression.
In plain wordsIn cells studied with Pal-KTTKS, stress fiber levels correlated with α-SMA expression.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
Direction not reportedStress fibers and α-SMA expression association
Study
n: not reported in source
Fibroblasts
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Stress fiber level and collagen contractility correlates with α-SMA expression level.
1 context sentence(design, population, supporting numbers)
Summary · context
The extent of α-SMA-positive fibroblasts was determined in collagen lattices and in cell culture study.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-3060346403
04LabNot a test of Matrixyl (palmitoyl pentapeptide-4) aloneIn vitro (cells)Mechanism
In fibroblast experiments involving Pal-KTTKS, collagen contractility correlated with α-SMA expression.
In plain wordsIn cells studied with Pal-KTTKS, collagen contraction correlated with α-SMA expression.
Peptide
Matrixyl (palmitoyl pentapeptide-4)
Outcome
Direction not reportedCollagen contractility and α-SMA expression association
Study
n: not reported in source
Fibroblasts
Outcome group
Wound healing · Skin and wound
Source sentences
Summary
Stress fiber level and collagen contractility correlates with α-SMA expression level.
1 context sentence(design, population, supporting numbers)
Summary · context
The extent of α-SMA-positive fibroblasts was determined in collagen lattices and in cell culture study.
In this study, Matrixyl (palmitoyl pentapeptide-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Matrixyl (palmitoyl pentapeptide-4).
Report a problemFND-3060346404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

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