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Study · Not a test of the peptide alone · 2019

1 result

The antinociceptive effects and molecular mechanisms of ghrelin(1-7)-NH2 at the supraspinal level in acute pain in mice.

Wu B, Liu Y, Liu F, Deng Q, Wang J, Han R, Zhang D, Chen J, Wei J

Brain research bulletin29 Dec 2018Cited by 8 (Europe PMC)

PMID30599218 (opens in a new tab)DOI10.1016/j.brainresbull.2018.12.016 (opens in a new tab)PepBankPUB-30599218
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In mice, co-injected D-Lys-GHRP‑6 fully antagonized the antinociceptive effect of ghrelin(1-7)-NH2.

    In plain wordsIn mice, D-Lys-GHRP‑6 blocked pain relief from the ghrelin fragment compared with the fragment alone.

    Peptide
    GHRP-6
    Outcome
    DecreaseGhrelin fragment-induced antinociception
    Study

    mousen: not reported in source

    tail withdrawal acute pain test
    Comparator
    Ghrelin(1-7)-NH2 alone
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    This antinociceptive effect was fully antagonized by co-injection with the GHS-R1α antagonist [D-Lys3]-GHRP-6, indicating that this effect induced by ghrelin(1-7)-NH2 was mediated through the activation of GHS-R1α.
    1 context sentence
    Summary · context
    Therefore in this study, we were interested in exploring the effects and molecular mechanisms of ghrelin(1-7)-NH2 in pain modulation at the supraspinal level using the tail withdrawal test in mice.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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