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Study · Randomized controlled trial · n = 76 · 2019

3 results

Effects of intranasal oxytocin on distraction as emotion regulation strategy in patients with post-traumatic stress disorder.

Koch SBJ, van Zuiden M, Nawijn L, Frijling JL, Veltman DJ, Olff M

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology13 Dec 2018Cited by 38 (Europe PMC)

PMID30554861 (opens in a new tab)DOI10.1016/j.euroneuro.2018.12.002 (opens in a new tab)PepBankPUB-30554861
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In police officers with and without PTSD, intranasal oxytocin enhanced left thalamus activity during distraction in all participants, independent of PTSD status or sex.

    In plain wordsIn police officers with and without PTSD, oxytocin increased activity in a brain area called the thalamus during a distraction task.

    Peptide
    Oxytocin
    Outcome
    IncreaseLeft thalamus activity during distraction
    Study

    n = 76

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Mental health and mood
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    After oxytocin administration, left thalamus activity during distraction was enhanced in all participants, independent of PTSD status or sex.
    1 context sentence
    Summary · context
    Therefore, we investigated behavioral and neural effects of intranasal oxytocin administration (40IU) on distraction as emotion regulation strategy in male and female police officers with and without PTSD (n = 76), using a randomized placebo-controlled cross-over fMRI study.
  2. 02HumanRandomized controlled trialMechanism

    In male police officers with PTSD, the decreased right striatal activity during distraction seen under placebo was unaffected by oxytocin.

    In plain wordsIn male police officers with PTSD, oxytocin did not change the lower activity in a brain area called the striatum during distraction.

    Peptide
    Oxytocin
    Outcome
    No significant changeRight striatal activity during distraction in male PTSD patients
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Mental health and mood
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Under placebo, male PTSD patients showed decreased right striatal activity during distraction compared to male trauma-exposed controls, which was unaffected by oxytocin.
    1 context sentence
    Summary · context
    Therefore, we investigated behavioral and neural effects of intranasal oxytocin administration (40IU) on distraction as emotion regulation strategy in male and female police officers with and without PTSD (n = 76), using a randomized placebo-controlled cross-over fMRI study.
  3. 03HumanRandomized controlled trialMechanism

    In police officers with PTSD and in male trauma-exposed controls, intranasal oxytocin increased functional connectivity between the left thalamus and amygdala.

    In plain wordsIn police officers with PTSD and in trauma-exposed men, oxytocin increased the connection between two emotion-related brain areas.

    Peptide
    Oxytocin
    Outcome
    IncreaseLeft thalamus-amygdala functional connectivity
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Mental health and mood
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Furthermore, oxytocin administration increased functional connectivity between the left thalamus and amygdala in PTSD patients and male trauma-exposed controls.
    1 context sentence
    Summary · context
    Therefore, we investigated behavioral and neural effects of intranasal oxytocin administration (40IU) on distraction as emotion regulation strategy in male and female police officers with and without PTSD (n = 76), using a randomized placebo-controlled cross-over fMRI study.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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